ES2150904T3 - Compuestos de tipo quinolizinona. - Google Patents

Compuestos de tipo quinolizinona.

Info

Publication number
ES2150904T3
ES2150904T3 ES91909628T ES91909628T ES2150904T3 ES 2150904 T3 ES2150904 T3 ES 2150904T3 ES 91909628 T ES91909628 T ES 91909628T ES 91909628 T ES91909628 T ES 91909628T ES 2150904 T3 ES2150904 T3 ES 2150904T3
Authority
ES
Spain
Prior art keywords
loweralkyl
group
loweralkoxy
amino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909628T
Other languages
English (en)
Inventor
Daniel T Chu
Cheuk M Lee
Qun Li
Curt S Cooper
Jacob J Plattner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2150904T3 publication Critical patent/ES2150904T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE DESCRIBEN COMPUESTOS NUEVOS CON LA FORMULA (I) ASI COMO SUS SALES, ESTERES Y AMIDAS FARMACEUTICAMENTE ACEPTABLES, EN DONDE R1 SE SELECCIONA DE (A) ALQUILO INFERIOR, (B) ALQUENILO INFERIOR, (C) HALO(ALQUILO INFERIOR), (D) ALCOXI INFERIOR, (E) CICLOALQUILO DE 3 A 8 CARBONOS, (F) FENILO, (G) HALO, (H) CIANO, (I) NITRO, (J) BICICLOALQUILO, (K) ALQUINILO INFERIOR, (L) ALCOXICARBONILO, (M) HETEROCICLO AROMATICO QUE CONTIENE NITROGENO Y (N) UN GRUPO CON LA FORMULA -NR7R8; R2 SE SELECCIONA DEL GRUPO FORMADO POR HALOGENO, ALCOXI INFERIOR, ARILOXI CARBOCICLICO O ARIL(ALQUILO INFERIOR)OXI CARBOCICLICO, ALQUILO INFERIOR, ALQUENILO INFERIOR, CICLOALQUILO DE 3 A 8 CARBONOS, CICLOALQUENILO DE 4 A 8 CARBONOS, ARIL(ALQUILO INFERIOR) CARBOCICLICO, CICLOALQUILO(ALQUILO INFERIOR), FENILO, AMINO, (ALQUILO INFERIOR)AMINO, ARIL(ALQUILO INFERIOR)AMINO CARBOCICLICO, (ALQUILO INFERIOR)AMINO SUBSTITUIDO CONTIENE NITROGENO, HETEROCICLO QUE CONTIENE NITROGENO BICICLICO Y HETEROCICLO QUE CONTIENE NITROGENO CON LA FORMULA (II), EN DONDE X TIENE UN VALOR DE 0 A 3; R9 SE SELECCIONA DE (A) H2)M, EN DONDE M TIENE UN VALOR DE 1, 2 O 3 Y (B) CH2)P-, EN DONDE R10 SE SELECCIONA DE S, O Y N, N TIENE UN VALOR DE 1 O 2, Y P TIENE UN VALOR DE 1 O 2; E Y ES UN SUBSTITUYENTE QUE NO ES HIDROGENO INDEPENDIENTEMENTE SELECCIONADO DE ALQUILO INFERIOR, HALO(ALQUILO INFERIOR), ALCOXI INFERIOR, ALQUILO INFERIOR SUBSTITUIDO POR HIDROXI, HIDROXI, AMINO(ALQUILO INFERIOR), HALOGENO Y UN GRUPO CON LA FORMULA -NR11R12; R3 ES HIDROGENO, HALOGENO O ALCOXI INFERIOR; R4 SE SELECCIONA DEL GRUPO FORMADO POR HIDROGENO, ALQUILO INFERIOR, UN CATION FARMACEUTICAMENTE ACEPTABLE Y UN GRUPO ESTER PROMEDICAMENTO; R5 SE SELECCIONA DEL GRUPO FORMADO POR HIDROGENO, HALOGENO, HIDROXI, ALQUILO INFERIOR, HALO(ALQUILO INFERIOR), ALCOXI INFERIOR Y UN GRUPO CON LA FORMULA -NR13R14; Y A ES N O CR6, EN DONDE R6 SE SELECCIONA DE HIDROGENO, HALOGENO, ALQUILO INFERIOR, HALO(ALQUILO INFERIOR), ALQUILO INFERIOR SUBSTITUIDO POR HIDROXI, ALCOXI INFERIOR(ALQUILOINFERIOR), ALCOXI INFERIOR Y AMINO(ALQUILO INFERIOR) O, ALTERNATIVAMENTE, R1 Y R6, TOMADOS JUNTO CON LOS ATOMOS A LOS QUE ESTAN UNIDOS, FORMAN UN ANILLO SATURADO DE 6 ELEMENTOS QUE PUEDE CONTENER UN ATOMO DE OXIGENO O AZUFRE Y QUE SE PUEDE SUBSTITUIR POR ALQUILO INFERIOR; CON LA CONDICION DE QUE CUANDO R5 SEA HIDROGENO Y A SEA CH O BIEN (A) R1 ES NR7R8 O BIEN (B) R2 ES UN GRUPO CON LA FORMULA (III), EN DONDE X TIENE UN VALOR DE 1-3 Y R9 E Y SON LO DEFINIDO ANTERIORMENTE.
ES91909628T 1990-05-02 1991-05-01 Compuestos de tipo quinolizinona. Expired - Lifetime ES2150904T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51778090A 1990-05-02 1990-05-02

Publications (1)

Publication Number Publication Date
ES2150904T3 true ES2150904T3 (es) 2000-12-16

Family

ID=24061202

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909628T Expired - Lifetime ES2150904T3 (es) 1990-05-02 1991-05-01 Compuestos de tipo quinolizinona.

Country Status (10)

Country Link
EP (1) EP0527889B1 (es)
JP (1) JP2514136B2 (es)
AT (1) ATE195122T1 (es)
CA (1) CA2081891C (es)
DE (1) DE69132348T2 (es)
DK (1) DK0527889T3 (es)
ES (1) ES2150904T3 (es)
GR (1) GR3034694T3 (es)
IE (1) IE911472A1 (es)
WO (1) WO1991016894A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599816A (en) * 1990-05-02 1997-02-04 Abbott Laboratories Quinolizinone type compounds
US5252747A (en) * 1992-09-11 1993-10-12 Abbott Laboratories Chiral quinolone intermediates
AU689809B2 (en) * 1993-10-14 1998-04-09 Abbott Laboratories Quinolizinone type compounds
NZ287550A (en) * 1994-07-18 1998-01-26 Ube Industries 8-trifluoromethylquinolinecarboxylic acid derivatives; medicaments
US5618813A (en) * 1995-05-26 1997-04-08 Abbott Laboratories Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents
IL122296A0 (en) * 1995-06-06 1998-04-05 Abbott Lab Quinolizinone type compounds
US5703244A (en) * 1996-11-21 1997-12-30 Abbott Laboratories Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
US5693813A (en) * 1997-02-26 1997-12-02 Abbott Laboratories Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
ID24703A (id) 1997-09-15 2000-08-03 Procter & Gamble Kuinolon antimikroba, komposisi dan penggunaannya
AU5991699A (en) * 1998-09-21 2000-04-10 Biochem Pharma Inc. Quinolizinones as integrin inhibitors
US6197974B1 (en) 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
AU2001286191A1 (en) * 2000-09-12 2002-03-26 Sankyo Company, Limited Quinolizine derivatives
NZ525570A (en) * 2000-12-14 2005-04-29 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
AU2002230891B2 (en) 2000-12-14 2005-04-07 The Procter & Gamble Company Antimicrobial quinolones
WO2006033422A1 (ja) * 2004-09-21 2006-03-30 Japan Tobacco Inc. キノリジノン化合物、およびそのｈｉｖインテグラーゼ阻害剤としての利用
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
BRPI0709772B8 (pt) 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1067079A (en) * 1976-07-22 1979-11-27 Yamanouchi Pharmaceutical Co. Nitrogen-containing heterobicyclic compounds
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
JPS57203085A (en) * 1981-06-09 1982-12-13 Dai Ichi Seiyaku Co Ltd 1,8-cyclic substituted quinoline derivative
GB8408292D0 (en) * 1984-03-30 1984-05-10 Fujisawa Pharmaceutical Co Quinolizinone compound
US4650804A (en) * 1984-03-30 1987-03-17 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3517535A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen 1-aryl-4-chinolon-3-carbonsaeuren
JPS6277385A (ja) * 1985-08-30 1987-04-09 Fujisawa Pharmaceut Co Ltd キノリジノン化合物、その製造法およびそれを含有する医薬組成物
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
US4877795A (en) * 1987-01-30 1989-10-31 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like
US4921857A (en) * 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
AU623474B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them

Also Published As

Publication number Publication date
DK0527889T3 (da) 2000-12-18
ATE195122T1 (de) 2000-08-15
WO1991016894A1 (en) 1991-11-14
GR3034694T3 (en) 2001-01-31
EP0527889A1 (en) 1993-02-24
JP2514136B2 (ja) 1996-07-10
CA2081891A1 (en) 1991-11-03
EP0527889A4 (en) 1994-08-10
EP0527889B1 (en) 2000-08-02
IE911472A1 (en) 1991-11-06
DE69132348T2 (de) 2001-03-15
DE69132348D1 (de) 2000-09-07
JPH05503709A (ja) 1993-06-17
CA2081891C (en) 1999-03-16

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