DE69132097T2 - Verbesserte nukleotid-säuren-sequenz analyse mit nukleoside-5'-o-(1-thiotriphosphaten) - Google Patents

Verbesserte nukleotid-säuren-sequenz analyse mit nukleoside-5'-o-(1-thiotriphosphaten)

Info

Publication number
DE69132097T2
DE69132097T2 DE69132097T DE69132097T DE69132097T2 DE 69132097 T2 DE69132097 T2 DE 69132097T2 DE 69132097 T DE69132097 T DE 69132097T DE 69132097 T DE69132097 T DE 69132097T DE 69132097 T2 DE69132097 T2 DE 69132097T2
Authority
DE
Germany
Prior art keywords
acid sequence
nucleoside
thiotriphosphates
nucleotid
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69132097T
Other languages
English (en)
Other versions
DE69132097D1 (de
Inventor
J Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of DE69132097D1 publication Critical patent/DE69132097D1/de
Publication of DE69132097T2 publication Critical patent/DE69132097T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69132097T 1990-09-28 1991-09-27 Verbesserte nukleotid-säuren-sequenz analyse mit nukleoside-5'-o-(1-thiotriphosphaten) Expired - Lifetime DE69132097T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/590,218 US5187085A (en) 1990-09-28 1990-09-28 Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
PCT/US1991/007345 WO1992006219A1 (en) 1990-09-28 1991-09-27 Improved nucleic acid sequence analysis with nucleoside-5'-0-(1-thiotriphosphates)

Publications (2)

Publication Number Publication Date
DE69132097D1 DE69132097D1 (de) 2000-05-11
DE69132097T2 true DE69132097T2 (de) 2000-10-12

Family

ID=24361335

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132097T Expired - Lifetime DE69132097T2 (de) 1990-09-28 1991-09-27 Verbesserte nukleotid-säuren-sequenz analyse mit nukleoside-5'-o-(1-thiotriphosphaten)

Country Status (6)

Country Link
US (1) US5187085A (de)
EP (1) EP0550646B1 (de)
JP (1) JPH0661280B2 (de)
AT (1) ATE191511T1 (de)
DE (1) DE69132097T2 (de)
WO (1) WO1992006219A1 (de)

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US4729947A (en) * 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
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US6207421B1 (en) 1984-03-29 2001-03-27 Li-Cor, Inc. DNA sequencing and DNA terminators
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6004446A (en) * 1984-03-29 1999-12-21 Li-Cor, Inc. DNA Sequencing
US6086737A (en) * 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
WO1994006812A1 (en) * 1992-09-18 1994-03-31 Amoco Corporation Green fluorescent labeled nucleotides for use in probes
DE69516325T2 (de) * 1994-02-22 2001-01-18 Mitsubishi Chem Corp Oligonukleotid und Verfahren zur Analyse der Basensequenz der Nukleinsäure
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6017702A (en) * 1996-12-05 2000-01-25 The Perkin-Elmer Corporation Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
CA2294465A1 (en) * 1997-06-25 1998-12-30 Life Technologies, Inc. Improved method for isolating and recovering target dna or rna molecules having a desired nucleotide sequence
AU9476598A (en) * 1997-09-11 1999-03-29 Seq, Ltd. Method to make fluorescent nucleotide photoproducts for dna sequencing and analysis
US5958694A (en) * 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
CA2319777C (en) 1998-02-04 2008-01-08 Amersham Pharmacia Biotech, Inc. Dideoxy dye terminators
US6787305B1 (en) * 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
US6610492B1 (en) 1998-10-01 2003-08-26 Variagenics, Inc. Base-modified nucleotides and cleavage of polynucleotides incorporating them
US6855500B2 (en) 1998-10-01 2005-02-15 Sequenom, Inc. Fluorescence-based genotyping
US6994998B1 (en) 1998-10-01 2006-02-07 Sequenom, Inc. Base-modified nucleotides and their use for polymorphism detection
US6777188B2 (en) 1998-10-01 2004-08-17 Variagenics, Inc. Genotyping by mass spectrometric analysis of allelic fragments
WO2000018967A1 (en) * 1998-10-01 2000-04-06 Variagenics, Inc. A method for analyzing polynucleotides
US6500650B1 (en) 1998-10-01 2002-12-31 Variagenics, Inc. Method for identifying polymorphisms
US6458945B1 (en) 1998-10-01 2002-10-01 Variagenics, Inc. Method for analyzing polynucleotides
US6440705B1 (en) 1998-10-01 2002-08-27 Vincent P. Stanton, Jr. Method for analyzing polynucleotides
US6566059B1 (en) 1998-10-01 2003-05-20 Variagenics, Inc. Method for analyzing polynucleotides
ATE383331T1 (de) * 1998-11-12 2008-01-15 Invitrogen Corp Transportreagentien
US6635419B1 (en) 1999-02-16 2003-10-21 Applera Corporation Polynucleotide sequencing method
ATE469699T1 (de) * 1999-02-23 2010-06-15 Caliper Life Sciences Inc Manipulation von mikroteilchen in mikrofluiden systemen
EP1163372A4 (de) * 1999-03-24 2002-10-02 Princeton Separations Chemisch reaktive in einer ebene erstarrte cyaninfarbstoffe sowie derivate
CA2382063A1 (en) * 1999-09-17 2001-03-22 Shiv Kumar Charge-modified nucleic acid terminators
US6399335B1 (en) * 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
FR2805826B1 (fr) * 2000-03-01 2002-09-20 Nucleica Nouvelles puces a adn
WO2003000187A2 (en) * 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
US7214428B2 (en) * 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
WO2003054507A2 (en) * 2001-09-17 2003-07-03 Biocrystal, Ltd. Nanocrystals
US7205048B2 (en) 2001-09-17 2007-04-17 Invitrogen Corporation Functionalized fluorescent nanocrystal compositions and methods of making
DE10246005A1 (de) * 2001-10-04 2003-04-30 Genovoxx Gmbh Gerät zur Sequenzierung von Nukleinsäuremolekülen
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US6723546B2 (en) * 2002-03-26 2004-04-20 New England Biolabs, Inc. Method for cloning and expression of BsaI restriction endonuclease and BsaI methylase in E. coli
JP2006509996A (ja) * 2002-04-02 2006-03-23 カリパー・ライフ・サイエンシズ・インコーポレーテッド サンプル生体材料の１種以上のサンプル成分を分離及び単離するための方法、システム及び装置
US20040126765A1 (en) * 2002-12-27 2004-07-01 Adams Craig W. Method and compositions for sequencing nucleic acid molecules
JP4177123B2 (ja) * 2003-01-10 2008-11-05 富士通株式会社 配線図形検証方法、プログラム及び装置
WO2006033732A1 (en) * 2004-08-17 2006-03-30 Invitrogen Corporation Synthesis of highly luminescent colloidal particles
US7368086B2 (en) * 2004-10-29 2008-05-06 Invitrogen Corporation Functionalized fluorescent nanocrystals, and methods for their preparation and use
JP5893442B2 (ja) * 2011-03-04 2016-03-23 国立大学法人宇都宮大学 チロシナーゼ活性阻害剤
EP3169310A1 (de) 2014-07-15 2017-05-24 Life Technologies Corporation Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen

Family Cites Families (1)

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DE3807975C2 (de) * 1988-03-10 2002-03-07 Karl Otto Greulich Verfahren zur optischen Charakterisierung von Nukleinsäuren und Oligonukleotiden

Also Published As

Publication number Publication date
WO1992006219A1 (en) 1992-04-16
EP0550646A1 (de) 1993-07-14
JPH05507000A (ja) 1993-10-14
ATE191511T1 (de) 2000-04-15
DE69132097D1 (de) 2000-05-11
US5187085A (en) 1993-02-16
JPH0661280B2 (ja) 1994-08-17
EP0550646A4 (en) 1994-05-25
EP0550646B1 (de) 2000-04-05

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Legal Events

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Owner name: APPLERA CORP., FOSTER CITY, CALIF., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8380 Miscellaneous part iii

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