DE69129604T2 - Mutierte beta-Lactamacylasegene - Google Patents

Mutierte beta-Lactamacylasegene

Info

Publication number
DE69129604T2
DE69129604T2 DE69129604T DE69129604T DE69129604T2 DE 69129604 T2 DE69129604 T2 DE 69129604T2 DE 69129604 T DE69129604 T DE 69129604T DE 69129604 T DE69129604 T DE 69129604T DE 69129604 T2 DE69129604 T2 DE 69129604T2
Authority
DE
Germany
Prior art keywords
beta
lactam
lactam acylase
mutant beta
acylase genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69129604T
Other languages
English (en)
Other versions
DE69129604D1 (de
Inventor
Wilhelmus Johannes Dr Quax
Der Laan Jan Metske Dr Van
Onno Dr Misset
Herman B M Dr Lenting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of DE69129604D1 publication Critical patent/DE69129604D1/de
Publication of DE69129604T2 publication Critical patent/DE69129604T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69129604T 1990-04-18 1991-04-18 Mutierte beta-Lactamacylasegene Expired - Fee Related DE69129604T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200962 1990-04-18

Publications (2)

Publication Number Publication Date
DE69129604D1 DE69129604D1 (de) 1998-07-23
DE69129604T2 true DE69129604T2 (de) 1998-10-15

Family

ID=8204994

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129604T Expired - Fee Related DE69129604T2 (de) 1990-04-18 1991-04-18 Mutierte beta-Lactamacylasegene

Country Status (10)

Country Link
US (2) US5457032A (de)
EP (1) EP0453048B1 (de)
JP (1) JPH05501806A (de)
KR (1) KR100193802B1 (de)
AT (1) ATE167520T1 (de)
DE (1) DE69129604T2 (de)
ES (1) ES2119756T3 (de)
IE (1) IE911295A1 (de)
PT (1) PT97409B (de)
WO (1) WO1991016435A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE911295A1 (en) * 1990-04-18 1991-10-23 Gist Brocades Nv Mutated beta-lactam acylase genes
ES2141796T3 (es) * 1993-08-05 2000-04-01 Dsm Nv Nuevo uso de acilasa de penicilina g de alcaligenes faecalis.
ATE189477T1 (de) * 1994-08-12 2000-02-15 Dsm Nv Mutierte penicillin-g-acylase gene
EP0961825B1 (de) * 1996-11-05 2008-07-30 Bristol-Myers Squibb Company Mutierte penicillin g acylasen
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
ES2531551T3 (es) * 2000-04-17 2015-03-17 Dyax Corp. Métodos para construir bibliotecas de presentación de paquetes genéticos para miembros de una familia diversa de péptido
US20030119056A1 (en) 2000-12-18 2003-06-26 Ladner Robert Charles Focused libraries of genetic packages
US20040067532A1 (en) * 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
WO2004111241A1 (en) * 2003-06-12 2004-12-23 Stichting Voor De Technische Wetenschappen Penicillin acylase
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1694835A2 (de) * 2003-12-05 2006-08-30 Stichting Voor De Technische Wetenschappen Glutaryl amidasen und deren verwendung
EP1538205A1 (de) * 2003-12-05 2005-06-08 Stichting Voor De Technische Wetenschappen Glutaryl Amidasen und deren Verwendung
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
WO2007073947A2 (en) 2005-12-28 2007-07-05 Dsm Ip Assets B.V. Mutant type ii beta- lactam acylases
CA2697193C (en) 2007-09-14 2017-06-06 Adimab, Inc. Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US9873957B2 (en) * 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
EP2281078B1 (de) 2008-04-24 2014-10-22 Dyax Corporation Bibliotheken von genetischen packungen, umfassend neue hc-cdr1, -cdr2, und -cdr3, und neue lc-cdr1-, -cdr2- und -cdr3-designs
US8247192B2 (en) * 2008-11-10 2012-08-21 Codexis, Inc. Penicillin-G acylases
CA2773564A1 (en) * 2009-09-14 2011-03-17 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
KR101963709B1 (ko) 2010-07-16 2019-04-01 아디맵 엘엘씨 항체 라이브러리
US10206404B2 (en) 2012-12-14 2019-02-19 Saban Ventures Pty Limited Disinfectant
EP2934120A4 (de) 2012-12-14 2016-08-17 Saban Ventures Pty Ltd Synergistische desinfektionsverbesserung
CN111172142B (zh) * 2020-02-14 2021-09-28 上海陶宇晟生物技术有限责任公司 一种热稳定性高的头孢菌素c酰化酶突变体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
ES2077151T3 (es) * 1990-04-18 1995-11-16 Gist Brocades Nv Penicilina g-acilasa, gen codificador de la misma y procedimiento de produccion de esta enzima.
IE911295A1 (en) * 1990-04-18 1991-10-23 Gist Brocades Nv Mutated beta-lactam acylase genes
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase

Also Published As

Publication number Publication date
ATE167520T1 (de) 1998-07-15
PT97409B (pt) 1998-08-31
JPH05501806A (ja) 1993-04-08
EP0453048A1 (de) 1991-10-23
KR100193802B1 (ko) 1999-06-15
DE69129604D1 (de) 1998-07-23
ES2119756T3 (es) 1998-10-16
US5935831A (en) 1999-08-10
PT97409A (pt) 1992-01-31
US5457032A (en) 1995-10-10
IE911295A1 (en) 1991-10-23
EP0453048B1 (de) 1998-06-17
WO1991016435A1 (en) 1991-10-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: DSM N.V., HEERLEN, NL

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8339 Ceased/non-payment of the annual fee