DE69124108D1 - Verfahren zur herstellung ölgefüllter paucilamellarer lipidvesikeln - Google Patents

Verfahren zur herstellung ölgefüllter paucilamellarer lipidvesikeln

Info

Publication number
DE69124108D1
DE69124108D1 DE69124108T DE69124108T DE69124108D1 DE 69124108 D1 DE69124108 D1 DE 69124108D1 DE 69124108 T DE69124108 T DE 69124108T DE 69124108 T DE69124108 T DE 69124108T DE 69124108 D1 DE69124108 D1 DE 69124108D1
Authority
DE
Germany
Prior art keywords
lipid vesicles
paucilamellar lipid
producing oil
loading
cold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124108T
Other languages
English (en)
Other versions
DE69124108T2 (de
Inventor
Donald Wallach
Rajiv Mathur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novavax Inc
Original Assignee
Micro Vesicular Systems Inc Nashua Nh Us
Micro Vesicular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Vesicular Systems Inc Nashua Nh Us, Micro Vesicular Systems Inc filed Critical Micro Vesicular Systems Inc Nashua Nh Us
Publication of DE69124108D1 publication Critical patent/DE69124108D1/de
Application granted granted Critical
Publication of DE69124108T2 publication Critical patent/DE69124108T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0017—Multi-phase liquid compositions
    • C11D17/0021—Aqueous microemulsions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
DE69124108T 1990-10-16 1991-10-15 Verfahren zur herstellung ölgefüllter paucilamellarer lipidvesikeln Expired - Fee Related DE69124108T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/598,120 US5160669A (en) 1988-03-03 1990-10-16 Method of making oil filled paucilamellar lipid vesicles
PCT/US1991/007701 WO1992006676A1 (en) 1990-10-16 1991-10-15 Method of making oil filled paucilamellar lipid vesicles

Publications (2)

Publication Number Publication Date
DE69124108D1 true DE69124108D1 (de) 1997-02-20
DE69124108T2 DE69124108T2 (de) 1997-04-17

Family

ID=24394319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124108T Expired - Fee Related DE69124108T2 (de) 1990-10-16 1991-10-15 Verfahren zur herstellung ölgefüllter paucilamellarer lipidvesikeln

Country Status (8)

Country Link
US (1) US5160669A (de)
EP (1) EP0558571B1 (de)
JP (1) JP3359031B2 (de)
AT (1) ATE147260T1 (de)
AU (1) AU8947691A (de)
CA (1) CA2093526C (de)
DE (1) DE69124108T2 (de)
WO (1) WO1992006676A1 (de)

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US5290542A (en) * 1993-04-08 1994-03-01 The Procter & Gamble Company Oral compositions for treating plaque and gingivitis
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ATE195866T1 (de) * 1993-07-28 2000-09-15 Pharmaderm Lab Ltd Zweiphasige multilamellare lipidvesikel
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CA2204398A1 (en) * 1994-11-03 1996-05-17 Donald F. H. Wallach Epoxy ester vesicles and paints
US5846551A (en) * 1996-06-10 1998-12-08 E-L Management Corp. Water-based makeup compositions and methods for their preparation
US5776536A (en) * 1996-12-23 1998-07-07 Igen, Inc. Reduced fat chocolate and method of manufacture
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US6039960A (en) 1997-05-28 2000-03-21 E-L Management Corp. Water containing wax-based product
DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
TW476788B (en) * 1998-04-08 2002-02-21 Kimberly Clark Co A cleanser and the making process thereof
US6251425B1 (en) 1998-10-02 2001-06-26 Igen, Inc. Glucoside paucilamellar vesicles
US6080211A (en) * 1999-02-19 2000-06-27 Igen, Inc. Lipid vesicle-based fuel additives and liquid energy sources containing same
US6309664B1 (en) * 1999-09-15 2001-10-30 Igen, Incorporated Methods, uses and compositions of fluid petrolatum
DE60137229D1 (de) * 2001-10-22 2009-02-12 Viroblock Sa Non-phospholipid Vesikel (npLV) und ihre Verwendung in kosmetischen, therapeutischen und prophylaktischen Anwendungen
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
US20040087564A1 (en) * 2002-10-31 2004-05-06 Wright D. Craig Delivery composition and method
CA2708437C (en) 2004-04-05 2013-05-14 Kanagawa University Emulsification dispersants, a method for emulsification and dispersion using the emulsification dispersants, emulsions, and emulsion fuels
US20050232973A1 (en) * 2004-04-19 2005-10-20 Makarand Gore Systems and methods for preparation of pharmaceutical dosage using compositions containing aqueous vesicles
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
US10251839B2 (en) * 2008-01-22 2019-04-09 Igi Laboratories, Inc. Lipid vesicles derived from olive oil fatty acids
DE102009026718A1 (de) 2009-06-04 2010-04-15 Henkel Ag & Co. Kgaa Hautbehandlung zur Porenverfeinerung II
US9849173B2 (en) 2009-07-06 2017-12-26 Variation Biotechnologies Inc. Methods for preparing vesicles and formulations produced therefrom
CA2803282C (en) 2009-07-06 2018-05-01 David E. Anderson Methods for preparing vesicles and formulations produced therefrom
US9506103B2 (en) * 2010-05-28 2016-11-29 Diagon Ltd. Procedure for biphasic preparation of liposomes and application thereof in manufacturing diagnostic reagents
AU2011276223C1 (en) 2010-07-06 2016-05-12 Variation Biotechnologies, Inc. Compositions and methods for treating influenza
EP2663288B1 (de) * 2011-01-13 2022-12-21 Variation Biotechnologies Inc. Verfahren zur vesikelherstellung und darin hergestellte formulierungen
MX359103B (es) 2011-01-13 2018-09-14 Variation Biotechnologies Inc Composiciones y sus usos en el tratamiento de infecciones virales.
CN104302323A (zh) 2012-01-12 2015-01-21 变异生物技术公司 用于治疗病毒感染的组合物和方法
RU2698906C2 (ru) 2012-01-27 2019-09-02 Вэриэйшн Биотекнолоджиз, Инк. Способы и композиции для терапевтических агентов

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CA795288A (en) * 1966-11-12 1968-09-24 Chapuis Jacques Encapsulated synthetic liquid detergent and process for preparing the same
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
FR2408387A2 (fr) * 1975-06-30 1979-06-08 Oreal Compositions a base de dispersions aqueuses de spherules lipidiques
FR2315991A1 (fr) * 1975-06-30 1977-01-28 Oreal Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4217344A (en) * 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
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Also Published As

Publication number Publication date
EP0558571A1 (de) 1993-09-08
ATE147260T1 (de) 1997-01-15
EP0558571A4 (en) 1993-10-27
DE69124108T2 (de) 1997-04-17
EP0558571B1 (de) 1997-01-08
US5160669A (en) 1992-11-03
WO1992006676A1 (en) 1992-04-30
JPH06504715A (ja) 1994-06-02
CA2093526C (en) 2002-12-24
CA2093526A1 (en) 1992-04-17
AU8947691A (en) 1992-05-20
JP3359031B2 (ja) 2002-12-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVAVAX INC.(N.D.GES.D.STAATES DELAWARE), COLUMBIA

8339 Ceased/non-payment of the annual fee