DE69123247D1 - Verfahren zur behandlung von alkoholsucht mit nalmefen - Google Patents

Verfahren zur behandlung von alkoholsucht mit nalmefen

Info

Publication number
DE69123247D1
DE69123247D1 DE69123247T DE69123247T DE69123247D1 DE 69123247 D1 DE69123247 D1 DE 69123247D1 DE 69123247 T DE69123247 T DE 69123247T DE 69123247 T DE69123247 T DE 69123247T DE 69123247 D1 DE69123247 D1 DE 69123247D1
Authority
DE
Germany
Prior art keywords
nalmefen
alcohol addiction
treating alcohol
treating
alcoholics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69123247T
Other languages
English (en)
Other versions
DE69123247T2 (de
Inventor
John Sinclair
Harry Scheinin
Risto Lammintausta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Contral Clinics Oy
Original Assignee
Alko Oy AB
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alko Oy AB, Orion Yhtyma Oy filed Critical Alko Oy AB
Publication of DE69123247D1 publication Critical patent/DE69123247D1/de
Application granted granted Critical
Publication of DE69123247T2 publication Critical patent/DE69123247T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
DE69123247T 1990-06-04 1991-05-10 Verfahren zur behandlung von alkoholsucht mit nalmefen Expired - Lifetime DE69123247T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/532,424 US5086058A (en) 1990-06-04 1990-06-04 Method for treating alcoholism with nalmefene
PCT/US1991/003241 WO1991018605A1 (en) 1990-06-04 1991-05-10 Method for treating alcoholism with nalmefene

Publications (2)

Publication Number Publication Date
DE69123247D1 true DE69123247D1 (de) 1997-01-02
DE69123247T2 DE69123247T2 (de) 1998-01-15

Family

ID=24121726

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123247T Expired - Lifetime DE69123247T2 (de) 1990-06-04 1991-05-10 Verfahren zur behandlung von alkoholsucht mit nalmefen

Country Status (19)

Country Link
US (1) US5086058A (de)
EP (1) EP0531415B1 (de)
JP (1) JP3059213B2 (de)
AT (1) ATE145329T1 (de)
AU (1) AU642748B2 (de)
CA (1) CA2084519C (de)
DE (1) DE69123247T2 (de)
DK (1) DK0531415T3 (de)
ES (1) ES2097209T3 (de)
FI (1) FI925513A0 (de)
GR (1) GR3022289T3 (de)
HU (1) HU210637B (de)
IE (1) IE77333B1 (de)
LT (1) LT3893B (de)
LV (1) LV10190B (de)
NZ (1) NZ238391A (de)
RU (1) RU2090190C1 (de)
WO (1) WO1991018605A1 (de)
ZA (1) ZA914185B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
US6271239B1 (en) * 1992-04-13 2001-08-07 Regents Of The University Of Minnesota Delta opioid receptor-selective benzylidene-substituted morphinans
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
US5580876A (en) * 1992-09-21 1996-12-03 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
USRE36547E (en) * 1992-09-21 2000-02-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists
US6096756A (en) * 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5298622A (en) * 1993-05-12 1994-03-29 Regents Of The University Of Minnesota Spiroindane opiate analogs
US5457208A (en) 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
US5587381A (en) * 1995-03-27 1996-12-24 Sinclair; John D. Method for terminating methadone maintenance through extinction of the opiate-taking responses
WO1997018781A1 (en) * 1995-11-20 1997-05-29 University Of Miami Method of treating nicotine dependence
US5878750A (en) * 1996-11-14 1999-03-09 Clemens; Anton H. Method of treating the syndrome of coronary heart disease risk factors in humans
US5780479A (en) * 1997-04-04 1998-07-14 Regents Of The University Of Minnesota Use of opioid antagonists to treat impulse-control disorders
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
RU2241458C2 (ru) 1997-12-22 2004-12-10 Эро-Селтик, С.А. Комбинации агонист/антагонист опиоида
UA53774C2 (uk) 1997-12-22 2003-02-17 Еро-Селтік, С.А. Спосіб запобігання зловживанню лікарськими формами, що містять опіоїди
WO2001040269A2 (en) * 1999-11-30 2001-06-07 Corixa Corporation Compositions and methods for therapy and diagnosis of breast cancer
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
SI2517710T1 (sl) 2000-02-08 2015-07-31 Euro-Celtique S.A. Oralne formulacije opioidnih agonistov, varne pred zlorabo
US20040024004A1 (en) * 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
US6528520B2 (en) * 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6262062B1 (en) * 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
JP4522652B2 (ja) 2001-05-11 2010-08-11 エンドー ファーマシューティカルズ， インコーポレイティド 乱用防止制御放出オピオイド投薬形態
EP1411352B1 (de) * 2001-07-13 2012-01-11 ARKRAY, Inc. Analysevorrichtung und durchstechelement- integrierte verbindung für eine konzentrationsanalysevorrichtung
AU2002316738B2 (en) * 2001-07-18 2009-01-08 Euro-Celtique S.A. Pharmaceutical combinations of oxycodone and naloxone
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
MXPA04001210A (es) 2001-08-06 2004-07-08 Euro Celtique Sa Formulaciones de agonista opioide con antagonista liberable y aislado.
US20030157168A1 (en) 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
JP2005508888A (ja) * 2001-08-14 2005-04-07 バイオティ セラピーズ コーポレイション アルコール依存症またはアルコール中毒を治療する方法
JP4620355B2 (ja) 2002-04-05 2011-01-26 ユーロ−セルティーク エス．エイ． 活性化合物の持続、不変及び独立放出のためのマトリクス
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP1509182A4 (de) * 2002-05-31 2009-12-30 Titan Pharmaceuticals Inc Implantierbare polymere vorrichtung zur verzögerten freisetzung von buprenorphin
CN1703200B (zh) 2002-09-20 2012-02-29 奥尔制药公司 隔离亚单元和相关组合物及方法
DK1610791T3 (da) 2003-03-31 2011-05-09 Titan Pharmaceuticals Inc Implanterbar polymer anordning for vedvarende frigivelse af dopamin-agonist
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
EP1613324A2 (de) * 2003-04-14 2006-01-11 Pain Therapeutics, Inc. Verfahren zur behandlung von schmerzen mit opioid-antagonisten
MY135852A (en) * 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US20060009478A1 (en) * 2003-10-15 2006-01-12 Nadav Friedmann Methods for the treatment of back pain
EP1604666A1 (de) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
EP1702558A1 (de) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
DK2719378T3 (en) 2006-06-19 2016-10-17 Alpharma Pharmaceuticals Llc pharmaceutical compositions
CA2666846C (en) * 2006-10-20 2018-04-10 Cpd, Llc Method of restoring the incretin effect
US20100266645A1 (en) * 2007-12-17 2010-10-21 Alfred Liang Pharmaceutical compositions
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
RU2495041C2 (ru) * 2008-04-24 2013-10-10 Янссен Фармацевтика Нв Диэфирные пролекарства налмефена
ME01319B (me) * 2008-04-24 2013-12-20 Janssen Pharmaceutica Nv Prolijekovi nalmefena
PE20110422A1 (es) * 2008-07-07 2011-07-01 Euro Celtique Sa Composicion farmaceutica que comprende antagonistas opioides
PT2405915T (pt) 2009-03-10 2019-01-29 Euro Celtique Sa Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona
US20140005217A1 (en) * 2012-06-27 2014-01-02 H. Lundbeck A/S Nalmefene for reduction of alcohol consumption in specific target populations
JP6419780B2 (ja) * 2013-04-17 2018-11-07 ハー・ルンドベック・アクチエゼルスカベット 睡眠障害患者の治療のためのナルメフェン
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
AR100153A1 (es) * 2014-04-22 2016-09-14 Otsuka Pharma Co Ltd Medicamento
CN107405343A (zh) 2014-11-07 2017-11-28 明尼苏达大学董事会 可用于治疗疾病的盐和组合物
CN117137917A (zh) * 2016-04-22 2023-12-01 景凯生物科技股份有限公司 纳美芬、纳曲酮或其衍生物在治疗(非)酒精性脂肪肝炎或非酒精性脂肪性肝病的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases
US4863928A (en) * 1989-01-04 1989-09-05 Baker Cummins Pharmaceuticals, Inc. Method of treatment for arthritic and inflammatory diseases
US5096715A (en) * 1989-11-20 1992-03-17 Alko Ltd. Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist

Also Published As

Publication number Publication date
GR3022289T3 (en) 1997-04-30
FI925513A (fi) 1992-12-04
HU210637B (en) 1995-06-28
NZ238391A (en) 1997-06-24
CA2084519A1 (en) 1991-12-05
AU7974091A (en) 1991-12-31
FI925513A0 (fi) 1992-12-04
HU9203835D0 (en) 1993-03-29
IE77333B1 (en) 1997-12-03
CA2084519C (en) 1999-02-09
AU642748B2 (en) 1993-10-28
JP3059213B2 (ja) 2000-07-04
LTIP1486A (en) 1995-09-25
WO1991018605A1 (en) 1991-12-12
LV10190A (lv) 1994-10-20
RU2090190C1 (ru) 1997-09-20
LT3893B (en) 1996-04-25
IE911888A1 (en) 1991-12-04
DK0531415T3 (da) 1996-12-09
DE69123247T2 (de) 1998-01-15
ES2097209T3 (es) 1997-04-01
ZA914185B (en) 1992-07-29
EP0531415B1 (de) 1996-11-20
HUT65523A (en) 1994-06-28
US5086058A (en) 1992-02-04
JPH06506665A (ja) 1994-07-28
LV10190B (en) 1995-06-20
EP0531415A1 (de) 1993-03-17
ATE145329T1 (de) 1996-12-15

Similar Documents

Publication Publication Date Title
ATE145329T1 (de) Verfahren zur behandlung von alkoholsucht mit nalmefen
RU92016403A (ru) Способ лечения алкоголизма налмефеном
DE69705218D1 (de) Verfahren zur herstellung von glinternden würfeleckigen retroflektierenden folien
DE69628938D1 (de) Verfahren zur herstellung synthetischer dieselbrennstoff
DE69431161T2 (de) Verfahren zur verbesserung von benzin
DE68902700D1 (de) Verfahren zur herstellung von synthetischem schmieroel durch olefinoligomerisation.
DE59603155D1 (de) Verfahren zur herstellung von hydrotalciten
DE60134590D1 (de) Verfahren zur Herstellung von kohlensäurehaltigem Wasser
DE59702613D1 (de) Verfahren zur herstellung von dienpolymerisatlösungen in vinylaromatischen monomeren
DE69628312D1 (de) Verfahren zur herstellung von getraenkedosenblech
DE69026695D1 (de) Verfahren zur herstellung von hochfestem rostfreien bandstahl mit ausgezeichneten federeigenschaften
DE59004541D1 (de) Verfahren zum Vermindern des Alkoholgehaltes alkoholischer Getränke.
DE557527T1 (de) Verfahren zur herstellung von hochoktanbenzin.
DE69021729D1 (de) Verfahren zur gewinnung von natürlich hergestelltem chymosin.
DE58904843D1 (de) Verfahren zur entfernung von ethanol aus durch vergaerung erzeugten getraenken.
DE69410715T2 (de) Verfahren zur Herstellung von Harzen mit niedrigem Glanz
DE58905117D1 (de) Verfahren zur herstellung von 4-chlor-2,5-dimethoxyanilin.
DE69703428T2 (de) Verfahren zur herstellung wässiger lösungen von tetraalkylammoniumhydroxiden
DE59104558D1 (de) Verfahren zur herstellung von konzentrierten wässrigen lösungen von anionischen azofarbstoffen.
DE3485006D1 (de) Verfahren zur herstellung von l-phenylalanin durch fermentation.
DE69625933T2 (de) Verfahren zur herstellung eines alkoholisches getränk durch fermentation und fermentationstestsatz zur durchführung des verfahrens
DE58902835D1 (de) Verfahren zur herstellung von schaumwein.
DE630393T1 (de) Verfahren zur herstellung von werkzeugen mit cad/cam.
DE69417061T2 (de) Verfahren zur herstellung von 2-chlor-1, 3-butadien pfropfcopolymeren
DE69109113D1 (de) Verfahren zur herstellung von cis-whiskey-lacton.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CONTRAL CLINICS OY, ESPOO, FI

8364 No opposition during term of opposition