DE69117029D1 - Verfahren zur herstellung eines durch einbau einer lipophilen wirksubstanz modifizierten lipoproteins - Google Patents
Verfahren zur herstellung eines durch einbau einer lipophilen wirksubstanz modifizierten lipoproteinsInfo
- Publication number
- DE69117029D1 DE69117029D1 DE69117029T DE69117029T DE69117029D1 DE 69117029 D1 DE69117029 D1 DE 69117029D1 DE 69117029 T DE69117029 T DE 69117029T DE 69117029 T DE69117029 T DE 69117029T DE 69117029 D1 DE69117029 D1 DE 69117029D1
- Authority
- DE
- Germany
- Prior art keywords
- lipoprotein
- active substance
- pct
- modified
- installing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004895 Lipoproteins Human genes 0.000 title abstract 6
- 108090001030 Lipoproteins Proteins 0.000 title abstract 6
- 239000013543 active substance Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000839 emulsion Substances 0.000 abstract 2
- 238000010348 incorporation Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 108010053156 lipid transfer protein Proteins 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9008980A FR2664500B1 (fr) | 1990-07-13 | 1990-07-13 | Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile, lipoproteine modifiee ainsi obtenue et composition pharmaceutique ou cosmetique la contenant. |
PCT/FR1991/000573 WO1992000761A1 (fr) | 1990-07-13 | 1991-07-12 | Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69117029D1 true DE69117029D1 (de) | 1996-03-21 |
DE69117029T2 DE69117029T2 (de) | 1996-09-19 |
Family
ID=9398707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69117029T Expired - Fee Related DE69117029T2 (de) | 1990-07-13 | 1991-07-12 | Verfahren zur herstellung eines durch einbau einer lipophilen wirksubstanz modifizierten lipoproteins |
Country Status (11)
Country | Link |
---|---|
US (1) | US5324821A (de) |
EP (1) | EP0491921B1 (de) |
JP (1) | JPH0786089B2 (de) |
AT (1) | ATE133867T1 (de) |
AU (1) | AU654144B2 (de) |
CA (1) | CA2066416A1 (de) |
DE (1) | DE69117029T2 (de) |
ES (1) | ES2042437T1 (de) |
FR (1) | FR2664500B1 (de) |
GR (1) | GR920300128T1 (de) |
WO (1) | WO1992000761A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
US5615801A (en) * | 1990-06-06 | 1997-04-01 | The Coca-Cola Company | Juice concentrate package for postmix dispenser |
US5842603A (en) * | 1990-06-06 | 1998-12-01 | The Coca-Cola Company | Postmix juice dispenser |
US5874059A (en) * | 1992-04-02 | 1999-02-23 | Fundacao E.J. Zerbini | Microemulsions labelled with radioactivity used as means for targeting neoplastic cells |
US6610321B2 (en) | 1996-07-03 | 2003-08-26 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
GB2321455A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
US6514523B1 (en) | 2000-02-14 | 2003-02-04 | Ottawa Heart Institute Research Corporation | Carrier particles for drug delivery and process for preparation |
US7803400B2 (en) | 2002-12-03 | 2010-09-28 | Blanchette Rockefeller Neurosciences Institute | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier |
EP1581186A2 (de) * | 2002-12-03 | 2005-10-05 | Blanchette Rockefeller Neurosciences Institute | Künstliche lipoprotein-träger niederer dichte für den transport von substanzen durch die blut/hirn-schranke |
JP4777873B2 (ja) | 2003-02-14 | 2011-09-21 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 親油性薬物送達ビヒクルおよびこれらの使用方法 |
DE10324256B4 (de) * | 2003-05-28 | 2010-04-22 | Merz Pharma Gmbh & Co. Kgaa | Lipid-Tranferprotein-Systeme und deren kosmetische/dermatologische Anwendung |
WO2006073419A2 (en) * | 2004-04-01 | 2006-07-13 | Gang Zheng | Lipoprotein nanoplatforms |
CN102159247A (zh) * | 2008-07-30 | 2011-08-17 | 日东电工株式会社 | 药物载体 |
US20160346219A1 (en) | 2015-06-01 | 2016-12-01 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
MX2018001227A (es) | 2015-07-30 | 2018-03-26 | Macrogenics Inc | Moleculas de union a pd-1 y metodos de uso de las mismas. |
UA125611C2 (uk) | 2015-12-14 | 2022-05-04 | Макродженікс, Інк. | Біспецифічні молекули, що мають імунореактивність відносно pd-1 і ctla-4, і способи їх застосування |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59163824A (ja) * | 1983-03-08 | 1984-09-14 | Hitachi Ltd | アライメントスコ−プ |
SE456136B (sv) * | 1985-06-17 | 1988-09-12 | Oncholab Ab | Forfarande for framstellning av en med ett lipofilt biologiskt aktivt emne bemengd berare pa basis av rekonstituerat ldl (lagdensitetslipoprotein) |
US5023271A (en) * | 1985-08-13 | 1991-06-11 | California Biotechnology Inc. | Pharmaceutical microemulsions |
FR2609399A1 (fr) * | 1987-01-13 | 1988-07-15 | Ire Celltarg Sa | Procede d'incorporation d'un ou plusieurs principes actifs lipophiles dans des lipoproteines, lipoproteines obtenues et composition pharmaceutique les contenant |
US5084441A (en) * | 1987-03-04 | 1992-01-28 | Shaw Jack M | Acetylated low density lipoproteins: a delivery system to phagocytic cells for stimulating immunologic response and host resistance |
WO1988009345A1 (en) * | 1987-05-20 | 1988-12-01 | The Rogosin Institute | Reconstituted hdl particles and uses thereof |
DE3815473A1 (de) * | 1988-05-06 | 1989-11-16 | Karl Heinz Prof Dr Dr Schmidt | Wirkstoff-system fuer den lipidaustausch mit zielstrukturen |
US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
-
1990
- 1990-07-13 FR FR9008980A patent/FR2664500B1/fr not_active Expired - Fee Related
-
1991
- 1991-07-12 CA CA002066416A patent/CA2066416A1/fr not_active Abandoned
- 1991-07-12 AU AU82157/91A patent/AU654144B2/en not_active Ceased
- 1991-07-12 DE DE69117029T patent/DE69117029T2/de not_active Expired - Fee Related
- 1991-07-12 JP JP3512790A patent/JPH0786089B2/ja not_active Expired - Fee Related
- 1991-07-12 WO PCT/FR1991/000573 patent/WO1992000761A1/fr active IP Right Grant
- 1991-07-12 AT AT91913037T patent/ATE133867T1/de not_active IP Right Cessation
- 1991-07-12 EP EP91913037A patent/EP0491921B1/de not_active Expired - Lifetime
- 1991-07-12 US US07/838,444 patent/US5324821A/en not_active Expired - Fee Related
- 1991-07-12 ES ES91913037T patent/ES2042437T1/es active Pending
-
1993
- 1993-03-16 GR GR920300128T patent/GR920300128T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU654144B2 (en) | 1994-10-27 |
ES2042437T1 (es) | 1993-12-16 |
EP0491921A1 (de) | 1992-07-01 |
GR920300128T1 (en) | 1993-03-16 |
DE69117029T2 (de) | 1996-09-19 |
CA2066416A1 (fr) | 1992-01-14 |
WO1992000761A1 (fr) | 1992-01-23 |
FR2664500A1 (fr) | 1992-01-17 |
JPH06500768A (ja) | 1994-01-27 |
US5324821A (en) | 1994-06-28 |
JPH0786089B2 (ja) | 1995-09-20 |
EP0491921B1 (de) | 1996-02-07 |
ATE133867T1 (de) | 1996-02-15 |
AU8215791A (en) | 1992-02-04 |
FR2664500B1 (fr) | 1994-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |