DE69116503T2 - Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität - Google Patents

Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität

Info

Publication number
DE69116503T2
DE69116503T2 DE69116503T DE69116503T DE69116503T2 DE 69116503 T2 DE69116503 T2 DE 69116503T2 DE 69116503 T DE69116503 T DE 69116503T DE 69116503 T DE69116503 T DE 69116503T DE 69116503 T2 DE69116503 T2 DE 69116503T2
Authority
DE
Germany
Prior art keywords
group
carbon atoms
chain
aminoglycoside
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69116503T
Other languages
English (en)
Other versions
DE69116503D1 (de
Inventor
William J Novick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69116503D1 publication Critical patent/DE69116503D1/de
Publication of DE69116503T2 publication Critical patent/DE69116503T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
DE69116503T 1990-10-30 1991-10-21 Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität Expired - Fee Related DE69116503T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/606,018 US5039666A (en) 1990-10-30 1990-10-30 Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside

Publications (2)

Publication Number Publication Date
DE69116503D1 DE69116503D1 (de) 1996-02-29
DE69116503T2 true DE69116503T2 (de) 1996-06-20

Family

ID=24426160

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116503T Expired - Fee Related DE69116503T2 (de) 1990-10-30 1991-10-21 Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität

Country Status (16)

Country Link
US (1) US5039666A (de)
EP (1) EP0483634B1 (de)
JP (1) JP3003333B2 (de)
KR (1) KR0139199B1 (de)
AT (1) ATE133072T1 (de)
AU (1) AU640056B2 (de)
CA (1) CA2054471C (de)
DE (1) DE69116503T2 (de)
DK (1) DK0483634T3 (de)
ES (1) ES2083500T3 (de)
GR (1) GR3018824T3 (de)
HU (1) HU213509B (de)
IE (1) IE70670B1 (de)
IL (1) IL99874A (de)
PT (1) PT99358B (de)
ZA (1) ZA918592B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE230990T1 (de) * 1992-03-04 2003-02-15 Cell Therapeutics Inc Enantiomere hydroxylierte xanthinverbindungen
JP3076672B2 (ja) * 1992-06-18 2000-08-14 三井化学株式会社 キノリン誘導体のフマル酸塩
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5340813A (en) * 1992-11-09 1994-08-23 Cell Therapeutics, Inc. Substituted aminoalkyl xanthine compounds
US5804584A (en) * 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
US6469017B1 (en) * 1998-01-16 2002-10-22 Cell Therapeutics, Inc. Method of inhibiting interleukin-12 signaling
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
WO1994015605A1 (en) * 1993-01-14 1994-07-21 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
AU6092794A (en) * 1993-01-19 1994-08-15 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
EP0739203A4 (de) * 1994-01-14 2000-12-20 Cell Therapeutics Inc Verfahren zur behandlung von erkrankungen, die durch zellproliferation als antwort auf pdgf, egf, fgf und vegf vermittelt werden
US6878715B1 (en) * 1994-02-18 2005-04-12 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
EP0746557A4 (de) * 1994-02-18 1997-05-02 Cell Therapeutics Inc Intrazellulärer signalübermittler
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US6075029A (en) * 1998-01-02 2000-06-13 Cell Therapeutics, Inc. Xanthine modulators of metabolism of cellular P-450
DE19823396A1 (de) * 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US6586429B2 (en) 2000-11-29 2003-07-01 Cell Therapeutics, Inc. Tricyclic fused xanthine compounds and their uses
US6825180B2 (en) 2001-05-18 2004-11-30 Cell Therapeutics, Inc. Pyridopyrimidine compounds and their uses
US7345018B2 (en) 2002-04-25 2008-03-18 Reception Aps Method of treating side effects induced by therapeutic agents
JP2006520761A (ja) * 2003-03-26 2006-09-14 レセプトイコン・アンパルトセルスカブ 薬物誘発性細胞毒性の予防のための化合物の使用
US20090110720A1 (en) * 2004-10-06 2009-04-30 Anders Nykjaer Use of compounds for the prevention of drug-induced cell toxicity
US7439343B2 (en) * 2005-09-01 2008-10-21 Rensselaer Polytechnic Institute Aminoglycoside-polyamine displacers and methods of use in displacement chromatography
WO2009152202A2 (en) * 2008-06-11 2009-12-17 Utah State University New aminoglycosides: synthesis and use as antifungals
US9669044B2 (en) 2010-12-14 2017-06-06 Utah State University Aminoglycoside and azole compositions and methods
US8865665B2 (en) 2010-12-14 2014-10-21 Utah State University Aminoglycosides: synthesis and use as antifungals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029882A (en) * 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US4002742A (en) * 1974-03-19 1977-01-11 Schering Corporation 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
EP0414175A3 (en) * 1989-08-22 1992-04-01 Hoechst Aktiengesellschaft Use of xanthine derivatives to reduce nephrotoxicity

Also Published As

Publication number Publication date
DE69116503D1 (de) 1996-02-29
US5039666A (en) 1991-08-13
HUT60136A (en) 1992-08-28
PT99358B (pt) 1999-03-31
AU8680291A (en) 1992-05-07
CA2054471A1 (en) 1992-05-01
IL99874A0 (en) 1992-08-18
IE70670B1 (en) 1996-12-11
KR920007630A (ko) 1992-05-27
PT99358A (pt) 1992-09-30
HU213509B (en) 1997-07-28
DK0483634T3 (da) 1996-05-20
EP0483634B1 (de) 1996-01-17
IE913775A1 (en) 1992-05-22
JPH04282315A (ja) 1992-10-07
IL99874A (en) 1995-08-31
ZA918592B (en) 1992-07-29
EP0483634A2 (de) 1992-05-06
GR3018824T3 (en) 1996-04-30
KR0139199B1 (ko) 1998-05-15
ATE133072T1 (de) 1996-02-15
CA2054471C (en) 1998-09-22
JP3003333B2 (ja) 2000-01-24
AU640056B2 (en) 1993-08-12
EP0483634A3 (en) 1992-10-14
ES2083500T3 (es) 1996-04-16
HU913392D0 (en) 1992-01-28

Similar Documents

Publication Publication Date Title
DE69116503T2 (de) Aminoglycosid-Zusammensetzung mit wesentlich verminderter Nephrotoxizität
GR3015194T3 (en) Indolocarbazole derivatives, process for their preparation and medicines containing same.
AU660469B2 (en) Pharmacologically active hydrazine derivatives and processes for the preparation thereof
ES8200679A1 (es) Un procedimiento para la preparacion de derivados de carboestirilo.
KR920009399A (ko) 면역 억제 활성을 갖는 약제를 제조하기 위한 크산틴의 용도
ES2017448A4 (es) Derivado de organopolisiloxano - urea y organopolisiloxano - tiourea
DE69119700T2 (de) Verwendung von Xanthinen zur Herstellung von Arzneimitteln zur Hemmung der Vermehrung menschlicher Retroviren
ATE113030T1 (de) Hydroxyalkancarbonsäure-derivate und deren verwendung.
MA20829A1 (fr) Nouvelles anthracyclines et compositions les contenant
ES8104182A1 (es) Procedimiento para preparar diaminas alquiladas
ATE24887T1 (de) Cycloaliphatische alkohole.
BG60269B2 (en) Process for the preparation of pyrimidine trione derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee