KR920007630A - 아미노글리코시드에 의해 유발된 신세포독성을 실질적으로 감소시킨 아미노글리코시드 조성물 - Google Patents
아미노글리코시드에 의해 유발된 신세포독성을 실질적으로 감소시킨 아미노글리코시드 조성물 Download PDFInfo
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- KR920007630A KR920007630A KR1019910019027A KR910019027A KR920007630A KR 920007630 A KR920007630 A KR 920007630A KR 1019910019027 A KR1019910019027 A KR 1019910019027A KR 910019027 A KR910019027 A KR 910019027A KR 920007630 A KR920007630 A KR 920007630A
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- aminoglycoside
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- (a)하나 이상의 일반적(I)의 7-(옥소알킬)1,3-디알킬크산틴, (b)일반식(Ⅱ)의 3급 하이드록시알킬크산틴 및 (c)이들의 적절한 혼합물로 이루어진 그룹중에서 선택된 화합물을 유효량으로 특징으로 하는 감소된 신세포독성을 갖는 아미노글리코시드 조성물.상기식에서, R1및 R2는 동일하거나 상이하며 탄소수 2 내지 6의 직쇄 또는 측쇄 알킬라디칼, 사이클러헥실, 직쇄 또는 측쇄 알콕시알킬 및 하이드록시알킬라디칼로 이루어진 그룹중에서 독립적으로 선택되고, A는 메틸그룹에 의해 치환될 수 있는 탄소수 4이하의 탄화수소 라디칼이며, R3및 R4중 적어도 하나는 일반식.그룹이고 n은 2내지 5이다)의 3급 하이드록시알킬 그룹이고, 임의로 존재할수 있는 다른 R3또는 R4그룹은 수소원자 또는 탄소수가 6이하이며 이의 탄소쇄가 2개 이하의 탄소원자로 차단되거나 옥소그룹 또는 2개이하의 하이드록실 그룹으로 치환될 수 있는 지방족 탄화수소 그룹 R7이며 R5는 탄소수 1 내지 4의 알킬 그룹이다.
- 제1항에 있어서, 상기 아미노글리코시드가 젠타마이신, 아미카신, 가나마이신, 네오마이신, 네틸리마이신, 스트렙토마이신, 넴브라마이신 및 이들의 적절한 혼합물로 구성된 그룹중에서 선택된 조성물.
- 제2항에 있어서, 상기 아미노글리코시드가 젠타마이신인 조성물.
- 제1항에 있어서, 화합물(a)가 (a′)1,3-디-n-부틸-7-(2-옥소프로필)크산틴, (b′)7-(3-옥소부틸)-1,3-디-n-부틸 크산틴(c′)이들의 적절한 혼합물로 구성된 그룹중에서 선택된 조성물.
- 제4항에 있어서, 아미노글리코시드가 젠타마이신인 조성물.
- 제1항에 있어서, 화합물(b)가 (a′)R3가이며, R5가 CH3인 화합물 (b)(b′)가 R3가R4가 H이며 R5가 CH3인 화합물 (b) 및 (c′)이들의 적절한 혼합물로 구성된 그룹중에서 선택된 조성물.
- 제6항에 있어서, 상기 아미노글리코시드가 젠타마이신인 조성물.
- 제7항에 있어서, 상기 화합물 (b) 및 (a′)인 조성물.
- 신세포 독성을 실질적으로 감소시키는 아미노글리코시드 조성물을 제조하기위한, (a)하나 이상의 일반식(I)의 7-(옥소알킬)1,3-디알킬 크산틴, (b)일반식(Ⅱ)의 3급 하이드록시알킬크산틴 및 (c)이들이 적절한 혼합물로 구성된 그룹으로부터선택된 화합물의 용도.상기식에서, R1및 R2는 동일하거나 상이하고 독립적으로 탄소수 2 내지 6의 직쇄 또는 측쇄 알킬 라디칼, 사이클로헥실, 직쇄 또는 측쇄 알콕시알킬 및 하이드록시알킬 라디칼로 이루어진 그룹중에서 선택되고, A는 메틸그룹에 의해 치환될 수 있는 탄소수 4이하의 탄화수소 라디칼이며,(여기서, R6가 탄소수 1 내지 3의 알킬 그룹이고 n은 2내지 5이다)의 3급 하이드록시알킬 그룹이고, 임의로 존재할수 있는 R3또는 R4중 다른 하나의 수소원자이거나 탄소수 6이하이고 이의 탄소쇄가 2개 이하의 산소원자로 차단도거나 옥소 그롭 또는 2개이하이 하이드록실 그룹으로 치환될 수 있는 지방족 탄화수소 그룹 R7이며, R5는 탄소수 1내지 4의 알킬 그룹이다.
- 제9항에 있어서, 상기 아미노글리코시드가 젠타마이신, 아미카신, 가나마이신, 네오마이신, 네틸리마이신, 스트렙토마이신, 넴브라마이신 및 이들의 적절한 혼합물로 구성된 그룹으로 부터 선택된 아미노글리코시드 조성물을 제조하기 위한 화합물의 용도.
- 제10항에 있어서, 아니노글리코시드가 젠타마이신인 아미노글리코시드 조성물을 제조하기 위한 화합물의 용도.
- 제9항에 있어서, 화합물(a)가(a′)1,3-디-n-부틸-ㅂ7-(2-옥소프로필)크산틴, (b′)1,3-디-n-부틸-7-(3-옥소부틸)크산틴 및(c′)이들의 적절한 혼합물로 이루어진 그룹중에서 선택된 화합물의 용도.
- 제9항에 있어서,화합물(b)(a′)R3가이며, R5가 CH3인 화합물 (b)(b′)R3가R4가 H이며 R5가 CH3인 화합물 (b) 및 (c′)이들의 적절한 혼합물로 구성된 그룹중에서 선택된 조성물.
- 제12항 또는 제13항에 있어서, 아미노글리코시드가 젠타마이신인 아미노글리코시드 화합물의 용도 제조하기 위한 화합물의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/606,018 US5039666A (en) | 1990-10-30 | 1990-10-30 | Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside |
US7/606,018 | 1990-10-30 | ||
US07/606,018 | 1990-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920007630A true KR920007630A (ko) | 1992-05-27 |
KR0139199B1 KR0139199B1 (ko) | 1998-05-15 |
Family
ID=24426160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910019027A KR0139199B1 (ko) | 1990-10-30 | 1991-10-29 | 아미노글리코시드에 의해 유발된 신세포독성을 실질적으로 감소시킨 아미노글리코시드 조성물 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5039666A (ko) |
EP (1) | EP0483634B1 (ko) |
JP (1) | JP3003333B2 (ko) |
KR (1) | KR0139199B1 (ko) |
AT (1) | ATE133072T1 (ko) |
AU (1) | AU640056B2 (ko) |
CA (1) | CA2054471C (ko) |
DE (1) | DE69116503T2 (ko) |
DK (1) | DK0483634T3 (ko) |
ES (1) | ES2083500T3 (ko) |
GR (1) | GR3018824T3 (ko) |
HU (1) | HU213509B (ko) |
IE (1) | IE70670B1 (ko) |
IL (1) | IL99874A (ko) |
PT (1) | PT99358B (ko) |
ZA (1) | ZA918592B (ko) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT584347E (pt) * | 1992-03-04 | 2003-06-30 | Cell Therapeutics Inc | Compostos de xantina hidroxilados enantiomericos |
JP3076672B2 (ja) * | 1992-06-18 | 2000-08-14 | 三井化学株式会社 | キノリン誘導体のフマル酸塩 |
US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
US5817662A (en) * | 1992-11-09 | 1998-10-06 | Cell Therapeutics, Inc. | Substituted amino alkyl compounds |
US5340813A (en) * | 1992-11-09 | 1994-08-23 | Cell Therapeutics, Inc. | Substituted aminoalkyl xanthine compounds |
US5473070A (en) * | 1992-11-16 | 1995-12-05 | Cell Therapeutics, Inc. | Substituted long chain alcohol xanthine compounds |
US6693105B1 (en) | 1992-11-16 | 2004-02-17 | Cell Therapeutics, Inc. | Hydroxyl-containing compounds |
US6469017B1 (en) * | 1998-01-16 | 2002-10-22 | Cell Therapeutics, Inc. | Method of inhibiting interleukin-12 signaling |
US5780476A (en) * | 1992-11-16 | 1998-07-14 | Cell Therapeutics, Inc. | Hydroxyl-containing xanthine compounds |
US5866576A (en) * | 1992-12-16 | 1999-02-02 | Cell Therapeutics, Inc. | Epoxide-containing compounds |
AU6087894A (en) * | 1993-01-14 | 1994-08-15 | Cell Therapeutics, Inc. | Acetal or ketal substituted therapeutic compounds |
WO1994016704A1 (en) * | 1993-01-19 | 1994-08-04 | Cell Therapeutics, Inc. | Oxime-substituted therapeutic compounds |
US5837703A (en) * | 1993-03-31 | 1998-11-17 | Cell Therapeutics, Inc. | Amino-alcohol substituted cyclic compounds |
US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
US6020337A (en) * | 1993-04-05 | 2000-02-01 | Cell Therapeutics, Inc. | Electronegative-substituted long chain xanthine compounds |
WO1995019171A1 (en) * | 1994-01-14 | 1995-07-20 | Cell Therapeutics, Inc. | Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf |
AU1967495A (en) * | 1994-02-18 | 1995-09-04 | Cell Therapeutics, Inc. | Intracellular signalling mediators |
US6878715B1 (en) * | 1994-02-18 | 2005-04-12 | Cell Therapeutics, Inc. | Therapeutic compounds for inhibiting interleukin-12 signals and method for using same |
US6103730A (en) * | 1994-03-24 | 2000-08-15 | Cell Therapeutics, Inc. | Amine substituted compounds |
US5801182A (en) * | 1994-03-24 | 1998-09-01 | Cell Therapeutics, Inc. | Amine substituted compounds |
US5807861A (en) * | 1994-03-24 | 1998-09-15 | Cell Therapeutics, Inc. | Amine substituted xanthinyl compounds |
US6075029A (en) * | 1998-01-02 | 2000-06-13 | Cell Therapeutics, Inc. | Xanthine modulators of metabolism of cellular P-450 |
DE19823396A1 (de) * | 1998-05-26 | 1999-12-02 | Bayer Ag | Synergistische insektizide Mischungen |
US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20030207901A1 (en) * | 1999-07-27 | 2003-11-06 | Cell Therapeutics, Inc. | Hydroxyl-containing compounds |
US6586429B2 (en) * | 2000-11-29 | 2003-07-01 | Cell Therapeutics, Inc. | Tricyclic fused xanthine compounds and their uses |
US6825180B2 (en) | 2001-05-18 | 2004-11-30 | Cell Therapeutics, Inc. | Pyridopyrimidine compounds and their uses |
US7345018B2 (en) | 2002-04-25 | 2008-03-18 | Reception Aps | Method of treating side effects induced by therapeutic agents |
EP1610773A2 (en) * | 2003-03-26 | 2006-01-04 | Recepticon ApS | Use of compounds for the prevention of drug-induced cell toxicity |
US20090110720A1 (en) * | 2004-10-06 | 2009-04-30 | Anders Nykjaer | Use of compounds for the prevention of drug-induced cell toxicity |
US7439343B2 (en) * | 2005-09-01 | 2008-10-21 | Rensselaer Polytechnic Institute | Aminoglycoside-polyamine displacers and methods of use in displacement chromatography |
WO2009152202A2 (en) * | 2008-06-11 | 2009-12-17 | Utah State University | New aminoglycosides: synthesis and use as antifungals |
US9669044B2 (en) | 2010-12-14 | 2017-06-06 | Utah State University | Aminoglycoside and azole compositions and methods |
EP2651959B1 (en) | 2010-12-14 | 2018-02-07 | Utah State University | Aminoglycosides:synthesis and use as antifungals |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4029882A (en) * | 1974-03-19 | 1977-06-14 | Schering Corporation | Selective acylation of the C-1 amino group of aminoglycoside antibiotics |
US4002742A (en) * | 1974-03-19 | 1977-01-11 | Schering Corporation | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor |
US4235892A (en) * | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
EP0414175A3 (en) * | 1989-08-22 | 1992-04-01 | Hoechst Aktiengesellschaft | Use of xanthine derivatives to reduce nephrotoxicity |
-
1990
- 1990-10-30 US US07/606,018 patent/US5039666A/en not_active Expired - Fee Related
-
1991
- 1991-10-21 ES ES91117907T patent/ES2083500T3/es not_active Expired - Lifetime
- 1991-10-21 EP EP91117907A patent/EP0483634B1/en not_active Expired - Lifetime
- 1991-10-21 DE DE69116503T patent/DE69116503T2/de not_active Expired - Fee Related
- 1991-10-21 DK DK91117907.5T patent/DK0483634T3/da active
- 1991-10-21 AT AT91117907T patent/ATE133072T1/de not_active IP Right Cessation
- 1991-10-28 IL IL9987491A patent/IL99874A/en not_active IP Right Cessation
- 1991-10-29 IE IE377591A patent/IE70670B1/en not_active IP Right Cessation
- 1991-10-29 AU AU86802/91A patent/AU640056B2/en not_active Ceased
- 1991-10-29 HU HU913392A patent/HU213509B/hu not_active IP Right Cessation
- 1991-10-29 CA CA002054471A patent/CA2054471C/en not_active Expired - Fee Related
- 1991-10-29 ZA ZA918592A patent/ZA918592B/xx unknown
- 1991-10-29 JP JP3282770A patent/JP3003333B2/ja not_active Expired - Lifetime
- 1991-10-29 KR KR1019910019027A patent/KR0139199B1/ko not_active IP Right Cessation
- 1991-10-29 PT PT99358A patent/PT99358B/pt not_active IP Right Cessation
-
1996
- 1996-01-31 GR GR960400212T patent/GR3018824T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69116503T2 (de) | 1996-06-20 |
IE70670B1 (en) | 1996-12-11 |
IE913775A1 (en) | 1992-05-22 |
AU640056B2 (en) | 1993-08-12 |
CA2054471A1 (en) | 1992-05-01 |
EP0483634A3 (en) | 1992-10-14 |
US5039666A (en) | 1991-08-13 |
DK0483634T3 (da) | 1996-05-20 |
EP0483634B1 (en) | 1996-01-17 |
HU213509B (en) | 1997-07-28 |
JP3003333B2 (ja) | 2000-01-24 |
PT99358B (pt) | 1999-03-31 |
ES2083500T3 (es) | 1996-04-16 |
ZA918592B (en) | 1992-07-29 |
EP0483634A2 (en) | 1992-05-06 |
PT99358A (pt) | 1992-09-30 |
KR0139199B1 (ko) | 1998-05-15 |
HUT60136A (en) | 1992-08-28 |
GR3018824T3 (en) | 1996-04-30 |
CA2054471C (en) | 1998-09-22 |
IL99874A (en) | 1995-08-31 |
JPH04282315A (ja) | 1992-10-07 |
DE69116503D1 (de) | 1996-02-29 |
IL99874A0 (en) | 1992-08-18 |
ATE133072T1 (de) | 1996-02-15 |
AU8680291A (en) | 1992-05-07 |
HU913392D0 (en) | 1992-01-28 |
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