DE69113982D1 - Neue 15,16-seco-19-nor-progestine. - Google Patents

Neue 15,16-seco-19-nor-progestine.

Info

Publication number
DE69113982D1
DE69113982D1 DE69113982T DE69113982T DE69113982D1 DE 69113982 D1 DE69113982 D1 DE 69113982D1 DE 69113982 T DE69113982 T DE 69113982T DE 69113982 T DE69113982 T DE 69113982T DE 69113982 D1 DE69113982 D1 DE 69113982D1
Authority
DE
Germany
Prior art keywords
seco
progestine
new
progestins
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113982T
Other languages
English (en)
Other versions
DE69113982T2 (de
Inventor
Richard Peters
Masato Tanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Application granted granted Critical
Publication of DE69113982D1 publication Critical patent/DE69113982D1/de
Publication of DE69113982T2 publication Critical patent/DE69113982T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
    • C07C49/423—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/453—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/573—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
    • C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/643—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69113982T 1990-09-05 1991-09-04 Neue 15,16-seco-19-nor-progestine. Expired - Fee Related DE69113982T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57809190A 1990-09-05 1990-09-05
US07/647,298 US5116865A (en) 1990-09-05 1991-01-28 15,16-seco-19-nor progestins
PCT/US1991/006333 WO1992004309A1 (en) 1990-09-05 1991-09-04 Novel 15,16-seco-19-nor progestins

Publications (2)

Publication Number Publication Date
DE69113982D1 true DE69113982D1 (de) 1995-11-23
DE69113982T2 DE69113982T2 (de) 1996-06-13

Family

ID=27077425

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113982T Expired - Fee Related DE69113982T2 (de) 1990-09-05 1991-09-04 Neue 15,16-seco-19-nor-progestine.

Country Status (7)

Country Link
US (3) US5116865A (de)
EP (1) EP0500899B1 (de)
JP (1) JPH05502462A (de)
AT (1) ATE129228T1 (de)
CA (1) CA2071917A1 (de)
DE (1) DE69113982T2 (de)
WO (1) WO1992004309A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins
US6083528A (en) * 1995-09-28 2000-07-04 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
US6551611B2 (en) 1995-09-28 2003-04-22 Schering Aktiengesellschaft Hormone replacement therapy method
US5922349A (en) * 1995-09-28 1999-07-13 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
CA2253502A1 (en) * 1996-05-06 1997-11-13 Stephen Warren Kaldor Anti-viral compounds
EP0811599B1 (de) 1996-05-06 2001-03-07 Eli Lilly And Company Antivirusverbindungen
CA2253401A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
WO1997041822A2 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
JP2000511514A (ja) * 1996-05-06 2000-09-05 イーライ・リリー・アンド・カンパニー 抗ウイルス化合物
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
WO1999066915A2 (en) 1998-06-23 1999-12-29 Southern Illinois University At Carbondale Therapeutic applications of estrogenic carboxylic acids
AP1542A (en) * 1999-04-30 2006-01-31 Pfizer Prod Inc Glucocorticoid receptor modulators.
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
JP2004523508A (ja) * 2001-01-04 2004-08-05 カロ バイオ アクチェブラーグ 新規エストロゲン受容体リガンドおよび方法ｉ

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL113064C (de) * 1960-03-12
US3109009A (en) * 1960-12-16 1963-10-29 Roussel Uclaf Method for preparation of 2alpha-alkyl-19-nor-testosterone and the intermediates obtained therefrom
US3275691A (en) * 1962-04-11 1966-09-27 Hoffmann La Roche Dodecahydrophenanthrene derivatives
US3471550A (en) * 1964-09-29 1969-10-07 Hoffmann La Roche 20beta-alkanoyloxy-5-oxo-3,5-seco-a-nor-pregnan-3-oic acids
US3478083A (en) * 1966-02-01 1969-11-11 Abbott Lab Nor-androstene steroid derivatives
GB1284902A (en) * 1969-04-03 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to hexahydrophenanthrene derivatives
US3839420A (en) * 1971-05-12 1974-10-01 Syntex Inc 16,17-seco-delta4 and delta5(10)steroids
US3822355A (en) * 1971-12-10 1974-07-02 Biolog Concepts Inc Novel oral contraceptive method
US3836651A (en) * 1972-02-22 1974-09-17 Biolog Concepts Inc Novel oral contraceptive combination
US3969502A (en) * 1972-04-14 1976-07-13 Schering Aktiengesellschaft Method for contraception by the administration of sequential contraceptive preparations
US3932635A (en) * 1972-04-24 1976-01-13 Syntex Corporation Novel cyclic progestogen-interrupted estrogen oral contraceptive regimens
US4066757A (en) * 1973-03-26 1978-01-03 Ortho Pharmaceutical Corporation Oral contraceptive regimen
US4145416A (en) * 1976-06-23 1979-03-20 Schering, A.G. Novel agents and novel methods for treatment of climacteric disturbances
US4874891A (en) * 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins

Also Published As

Publication number Publication date
US5321044A (en) 1994-06-14
EP0500899A1 (de) 1992-09-02
EP0500899B1 (de) 1995-10-18
WO1992004309A1 (en) 1992-03-19
DE69113982T2 (de) 1996-06-13
JPH05502462A (ja) 1993-04-28
ATE129228T1 (de) 1995-11-15
US5116865A (en) 1992-05-26
US5478862A (en) 1995-12-26
CA2071917A1 (en) 1992-03-06

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Legal Events

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8339 Ceased/non-payment of the annual fee