DE69108746D1 - Herstellung und Trennung von Ibuprofen-lysinat. - Google Patents

Herstellung und Trennung von Ibuprofen-lysinat.

Info

Publication number
DE69108746D1
DE69108746D1 DE69108746T DE69108746T DE69108746D1 DE 69108746 D1 DE69108746 D1 DE 69108746D1 DE 69108746 T DE69108746 T DE 69108746T DE 69108746 T DE69108746 T DE 69108746T DE 69108746 D1 DE69108746 D1 DE 69108746D1
Authority
DE
Germany
Prior art keywords
separation
production
ibuprofen lysinate
lysinate
ibuprofen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108746T
Other languages
English (en)
Other versions
DE69108746T2 (de
Inventor
Hsien-Hsin Tung
Stanley Waterson
Scott D Reynolds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69108746D1 publication Critical patent/DE69108746D1/de
Publication of DE69108746T2 publication Critical patent/DE69108746T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
DE69108746T 1990-01-10 1991-01-10 Herstellung und Trennung von Ibuprofen-lysinat. Expired - Fee Related DE69108746T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/463,198 US4994604A (en) 1990-01-10 1990-01-10 Formation and resolution of ibuprofen lysinate

Publications (2)

Publication Number Publication Date
DE69108746D1 true DE69108746D1 (de) 1995-05-18
DE69108746T2 DE69108746T2 (de) 1995-11-23

Family

ID=23839247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108746T Expired - Fee Related DE69108746T2 (de) 1990-01-10 1991-01-10 Herstellung und Trennung von Ibuprofen-lysinat.

Country Status (5)

Country Link
US (1) US4994604A (de)
EP (1) EP0437369B1 (de)
JP (1) JP2875894B2 (de)
CA (1) CA2033871A1 (de)
DE (1) DE69108746T2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0505180T3 (da) * 1991-03-22 1997-03-24 Merck & Co Inc Farmaceutisk præparat med højt indhold af ibuprofenlysinat
ATE195417T1 (de) * 1991-05-13 2000-09-15 Boots Co Plc Ibuprofen-salz enthaltende pharmazeutische zusammensetzung
IT1255007B (it) * 1991-07-01 1995-10-11 Altergon Sa Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.
US5191114A (en) * 1991-10-09 1993-03-02 Sage Pharmaceuticals, Inc. Process for enhancing the flow characteristics of ibuprofen
US5302751A (en) * 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
US5260337A (en) * 1992-07-29 1993-11-09 Merck & Co., Inc. Ibuprofen-muscle relaxant combinations
US5288507A (en) * 1992-07-29 1994-02-22 Merck & Co., Inc. Ibuprofen antacid combinations
WO1994003209A1 (en) * 1992-07-29 1994-02-17 Merck & Co., Inc. Dexibuprofen/antacid/simethicone combinations
EP0663839A4 (de) * 1992-09-29 1998-06-03 Merck & Co Inc Kombinationen von ibuprofen mit einem h2-antagonisten.
JPH08504193A (ja) * 1992-12-02 1996-05-07 ザ ブーツ カンパニー ピーエルシー 方 法
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
US5332834A (en) * 1992-12-02 1994-07-26 Hoechst Celanese Corporation Racemization of an enantomerically enriched α-aryl carboxylic acid
IT1264855B1 (it) * 1993-06-21 1996-10-17 Zambon Spa Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici
US5310961A (en) * 1993-07-02 1994-05-10 Affinity Biotech, Inc. Neomorphic ibuprofen
WO1995007079A1 (en) * 1993-09-07 1995-03-16 The Procter & Gamble Company Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agents and caffeine
US5621140A (en) * 1994-12-22 1997-04-15 Syntex (U.S.A.) Inc. Resolution of ibuprofen
CN1186483A (zh) * 1995-05-05 1998-07-01 赫希斯特人造丝公司 α－芳基丙酸酯非对映体的蒸馏分离
IN189741B (de) * 1998-11-09 2003-04-19 Council Scient Ind Res
US6342530B1 (en) 2000-11-14 2002-01-29 Farmacon-Il, Llc Composition and method for parenteral administration of ibuprofen d,l- or l-lysine salt
US6344479B1 (en) 2001-03-20 2002-02-05 Farmacon-Il, Llc Method of preventing retinopathy of prematurity in a neonate
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US20050025791A1 (en) * 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
KR100917593B1 (ko) 2007-08-09 2009-09-17 대화제약 주식회사 덱시부프로펜염의 제조방법
US20140045724A1 (en) * 2012-08-10 2014-02-13 Jon Selbo Formulation screening methods, apparatuses for performing such methods and formulations formed by such methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1210495A (en) * 1966-11-15 1970-10-28 Struthers Scientific Int Corp Selective crystallization
US3925454A (en) * 1968-04-22 1975-12-09 Tanabe Seiyaku Co Preparation of optically active isomers of lysines
US4709082A (en) * 1984-10-25 1987-11-24 Nissan Chemical Industries, Ltd. 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof

Also Published As

Publication number Publication date
DE69108746T2 (de) 1995-11-23
CA2033871A1 (en) 1991-07-11
EP0437369B1 (de) 1995-04-12
EP0437369A3 (en) 1992-06-10
JPH04253941A (ja) 1992-09-09
EP0437369A2 (de) 1991-07-17
US4994604A (en) 1991-02-19
JP2875894B2 (ja) 1999-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee