DE69105338D1 - Verfahren zur Herstellung von 1-(2,3,4-Trimethoxybenzyl)-Piperazin durch reduktive Aminierung. - Google Patents

Verfahren zur Herstellung von 1-(2,3,4-Trimethoxybenzyl)-Piperazin durch reduktive Aminierung.

Info

Publication number
DE69105338D1
DE69105338D1 DE69105338T DE69105338T DE69105338D1 DE 69105338 D1 DE69105338 D1 DE 69105338D1 DE 69105338 T DE69105338 T DE 69105338T DE 69105338 T DE69105338 T DE 69105338T DE 69105338 D1 DE69105338 D1 DE 69105338D1
Authority
DE
Germany
Prior art keywords
piperazine
preparation
trimethoxybenzyl
reductive amination
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69105338T
Other languages
English (en)
Other versions
DE69105338T2 (de
Inventor
Jean-Claude Souvie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69105338D1 publication Critical patent/DE69105338D1/de
Application granted granted Critical
Publication of DE69105338T2 publication Critical patent/DE69105338T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE69105338T 1990-04-20 1991-04-18 Verfahren zur Herstellung von 1-(2,3,4-Trimethoxybenzyl)-Piperazin durch reduktive Aminierung. Expired - Lifetime DE69105338T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9005027A FR2661176B1 (fr) 1990-04-20 1990-04-20 Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.

Publications (2)

Publication Number Publication Date
DE69105338D1 true DE69105338D1 (de) 1995-01-12
DE69105338T2 DE69105338T2 (de) 1995-06-08

Family

ID=9395904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69105338T Expired - Lifetime DE69105338T2 (de) 1990-04-20 1991-04-18 Verfahren zur Herstellung von 1-(2,3,4-Trimethoxybenzyl)-Piperazin durch reduktive Aminierung.

Country Status (15)

Country Link
US (1) US5142053A (de)
EP (1) EP0453365B1 (de)
JP (1) JPH0735374B2 (de)
AT (1) ATE114647T1 (de)
AU (1) AU631735B2 (de)
CA (1) CA2040884C (de)
DE (1) DE69105338T2 (de)
DK (1) DK0453365T3 (de)
ES (1) ES2067882T3 (de)
FR (1) FR2661176B1 (de)
IE (1) IE65723B1 (de)
NZ (1) NZ237886A (de)
OA (1) OA09493A (de)
PT (1) PT97425B (de)
ZA (1) ZA912949B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109307725A (zh) * 2018-10-31 2019-02-05 远大医药（中国）有限公司 一种盐酸曲美他嗪的分析方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
FR2703048B1 (fr) * 1993-03-24 1996-01-05 Adir Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2827284B1 (fr) * 2001-07-16 2003-10-31 Servier Lab Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN100413854C (zh) * 2004-06-29 2008-08-27 北京德众万全药物技术开发有限公司 一种曲美他嗪及其药用盐的制备方法
CN101575321B (zh) * 2009-06-18 2011-04-06 绍兴文理学院 曲美他嗪及其盐酸盐的生产方法
CN102140084A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 一种曲美他嗪及其盐酸盐的生产方法
CN102010386B (zh) * 2010-11-10 2012-07-11 武汉武药科技有限公司 一种制备盐酸曲美他嗪的方法
CN102993122B (zh) * 2012-12-24 2015-03-04 武汉武药制药有限公司 盐酸曲美他嗪的合成新路线

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR805M (de) * 1960-06-30 1961-09-01
FR1302958A (fr) * 1961-03-21 1962-09-07 Science Union & Cie Préparations des dérivés trialcoxylés de la benzyl-1 pipérazine
JPS4930838B2 (de) * 1971-08-25 1974-08-16
NL7306771A (de) * 1972-06-02 1973-12-04
AT332863B (de) * 1973-01-02 1976-10-25 Gerot Pharmazeutika Verfahren zur herstellung von neuen 2-aminomethyl-4,6-dihalogenphenolderivaten sowie deren additionssalzen mit sauren
US3951970A (en) * 1973-10-01 1976-04-20 Sharps Associates Resorcinol amine derivatives
JPS53112887A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
JPS607990B2 (ja) * 1980-10-13 1985-02-28 日本新薬株式会社 ベンジルピペラジン誘導体
FR2493316A1 (fr) * 1980-11-06 1982-05-07 Science Union & Cie Nouveau procede de preparation des (trialcoxy benzyl)-1 piperazines et notamment de la (trimethoxy-2', 3', 4' benzyl)-1 piperazine
GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109307725A (zh) * 2018-10-31 2019-02-05 远大医药（中国）有限公司 一种盐酸曲美他嗪的分析方法
CN109307725B (zh) * 2018-10-31 2021-08-17 远大医药（中国）有限公司 一种盐酸曲美他嗪的分析方法

Also Published As

Publication number Publication date
IE65723B1 (en) 1995-11-15
AU631735B2 (en) 1992-12-03
PT97425A (pt) 1992-01-31
EP0453365B1 (de) 1994-11-30
DK0453365T3 (da) 1995-05-01
EP0453365A1 (de) 1991-10-23
US5142053A (en) 1992-08-25
ES2067882T3 (es) 1995-04-01
CA2040884A1 (fr) 1991-10-21
JPH04224571A (ja) 1992-08-13
NZ237886A (en) 1992-03-26
ZA912949B (en) 1992-01-29
ATE114647T1 (de) 1994-12-15
CA2040884C (fr) 1999-05-18
FR2661176B1 (fr) 1992-06-12
OA09493A (fr) 1992-11-15
DE69105338T2 (de) 1995-06-08
FR2661176A1 (fr) 1991-10-25
AU7515191A (en) 1991-10-24
JPH0735374B2 (ja) 1995-04-19
IE911313A1 (en) 1991-10-23
PT97425B (pt) 1998-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR