ATE114647T1 - Verfahren zur herstellung von 1-(2,3,4- trimethoxybenzyl)-piperazin durch reduktive aminierung. - Google Patents

Verfahren zur herstellung von 1-(2,3,4- trimethoxybenzyl)-piperazin durch reduktive aminierung.

Info

Publication number
ATE114647T1
ATE114647T1 AT91401025T AT91401025T ATE114647T1 AT E114647 T1 ATE114647 T1 AT E114647T1 AT 91401025 T AT91401025 T AT 91401025T AT 91401025 T AT91401025 T AT 91401025T AT E114647 T1 ATE114647 T1 AT E114647T1
Authority
AT
Austria
Prior art keywords
piperazine
preparation
trimethoxybenzyl
reductive amination
compound
Prior art date
Application number
AT91401025T
Other languages
English (en)
Inventor
Jean-Claude Souvie
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE114647T1 publication Critical patent/ATE114647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
AT91401025T 1990-04-20 1991-04-18 Verfahren zur herstellung von 1-(2,3,4- trimethoxybenzyl)-piperazin durch reduktive aminierung. ATE114647T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9005027A FR2661176B1 (fr) 1990-04-20 1990-04-20 Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.

Publications (1)

Publication Number Publication Date
ATE114647T1 true ATE114647T1 (de) 1994-12-15

Family

ID=9395904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91401025T ATE114647T1 (de) 1990-04-20 1991-04-18 Verfahren zur herstellung von 1-(2,3,4- trimethoxybenzyl)-piperazin durch reduktive aminierung.

Country Status (15)

Country Link
US (1) US5142053A (de)
EP (1) EP0453365B1 (de)
JP (1) JPH0735374B2 (de)
AT (1) ATE114647T1 (de)
AU (1) AU631735B2 (de)
CA (1) CA2040884C (de)
DE (1) DE69105338T2 (de)
DK (1) DK0453365T3 (de)
ES (1) ES2067882T3 (de)
FR (1) FR2661176B1 (de)
IE (1) IE65723B1 (de)
NZ (1) NZ237886A (de)
OA (1) OA09493A (de)
PT (1) PT97425B (de)
ZA (1) ZA912949B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
FR2703048B1 (fr) * 1993-03-24 1996-01-05 Adir Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2827284B1 (fr) * 2001-07-16 2003-10-31 Servier Lab Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN100413854C (zh) * 2004-06-29 2008-08-27 北京德众万全药物技术开发有限公司 一种曲美他嗪及其药用盐的制备方法
CN101575321B (zh) * 2009-06-18 2011-04-06 绍兴文理学院 曲美他嗪及其盐酸盐的生产方法
CN102140084A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 一种曲美他嗪及其盐酸盐的生产方法
CN102010386B (zh) * 2010-11-10 2012-07-11 武汉武药科技有限公司 一种制备盐酸曲美他嗪的方法
CN102993122B (zh) * 2012-12-24 2015-03-04 武汉武药制药有限公司 盐酸曲美他嗪的合成新路线
CN109307725B (zh) * 2018-10-31 2021-08-17 远大医药（中国）有限公司 一种盐酸曲美他嗪的分析方法
CN118420566A (zh) * 2024-04-26 2024-08-02 海南锦麟医药科技有限公司 一种高纯度盐酸曲美他嗪的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR805M (de) * 1960-06-30 1961-09-01
FR1302958A (fr) * 1961-03-21 1962-09-07 Science Union & Cie Préparations des dérivés trialcoxylés de la benzyl-1 pipérazine
JPS4930838B2 (de) * 1971-08-25 1974-08-16
NL7306771A (de) * 1972-06-02 1973-12-04
AT332863B (de) * 1973-01-02 1976-10-25 Gerot Pharmazeutika Verfahren zur herstellung von neuen 2-aminomethyl-4,6-dihalogenphenolderivaten sowie deren additionssalzen mit sauren
US3951970A (en) * 1973-10-01 1976-04-20 Sharps Associates Resorcinol amine derivatives
JPS53112887A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
JPS607990B2 (ja) * 1980-10-13 1985-02-28 日本新薬株式会社 ベンジルピペラジン誘導体
FR2493316A1 (fr) * 1980-11-06 1982-05-07 Science Union & Cie Nouveau procede de preparation des (trialcoxy benzyl)-1 piperazines et notamment de la (trimethoxy-2', 3', 4' benzyl)-1 piperazine
GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents

Also Published As

Publication number Publication date
AU631735B2 (en) 1992-12-03
IE65723B1 (en) 1995-11-15
OA09493A (fr) 1992-11-15
DE69105338D1 (de) 1995-01-12
ZA912949B (en) 1992-01-29
CA2040884C (fr) 1999-05-18
DE69105338T2 (de) 1995-06-08
EP0453365A1 (de) 1991-10-23
IE911313A1 (en) 1991-10-23
PT97425B (pt) 1998-08-31
CA2040884A1 (fr) 1991-10-21
EP0453365B1 (de) 1994-11-30
ES2067882T3 (es) 1995-04-01
AU7515191A (en) 1991-10-24
JPH0735374B2 (ja) 1995-04-19
FR2661176A1 (fr) 1991-10-25
US5142053A (en) 1992-08-25
JPH04224571A (ja) 1992-08-13
PT97425A (pt) 1992-01-31
DK0453365T3 (da) 1995-05-01
FR2661176B1 (fr) 1992-06-12
NZ237886A (en) 1992-03-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time