DE69105188D1 - Asporogener Stamm von Bacillus substilis und seine Verwendung als Wirt in der Herstellung von heterologen Produkten. - Google Patents

Asporogener Stamm von Bacillus substilis und seine Verwendung als Wirt in der Herstellung von heterologen Produkten.

Info

Publication number
DE69105188D1
DE69105188D1 DE69105188T DE69105188T DE69105188D1 DE 69105188 D1 DE69105188 D1 DE 69105188D1 DE 69105188 T DE69105188 T DE 69105188T DE 69105188 T DE69105188 T DE 69105188T DE 69105188 D1 DE69105188 D1 DE 69105188D1
Authority
DE
Germany
Prior art keywords
host
production
strain
heterologous products
bacillus substilis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69105188T
Other languages
English (en)
Other versions
DE69105188T2 (de
Inventor
Gianni Frascotti
Paola Cosmina
Guido Grandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Eniricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche SpA filed Critical Eniricerche SpA
Application granted granted Critical
Publication of DE69105188D1 publication Critical patent/DE69105188D1/de
Publication of DE69105188T2 publication Critical patent/DE69105188T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69105188T 1990-12-21 1991-12-11 Asporogener Stamm von Bacillus substilis und seine Verwendung als Wirt in der Herstellung von heterologen Produkten. Expired - Fee Related DE69105188T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02247690A IT1244477B (it) 1990-12-21 1990-12-21 Ceppo asporigeno di bacillus subtilis e suo impiego come ospite per la preparazione di prodotti eterologhi

Publications (2)

Publication Number Publication Date
DE69105188D1 true DE69105188D1 (de) 1994-12-22
DE69105188T2 DE69105188T2 (de) 1995-05-18

Family

ID=11196787

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69105188T Expired - Fee Related DE69105188T2 (de) 1990-12-21 1991-12-11 Asporogener Stamm von Bacillus substilis und seine Verwendung als Wirt in der Herstellung von heterologen Produkten.

Country Status (9)

Country Link
US (1) US6284490B1 (de)
EP (1) EP0492274B1 (de)
JP (1) JP3013008B2 (de)
AT (1) ATE114171T1 (de)
DE (1) DE69105188T2 (de)
DK (1) DK0492274T3 (de)
ES (1) ES2074208T3 (de)
GR (1) GR3014979T3 (de)
IT (1) IT1244477B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1391502B1 (de) * 2001-05-29 2012-04-25 Kao Corporation Wirtsmikroorganismen
GB0116798D0 (en) 2001-07-10 2001-08-29 Secr Defence Expression system
CA2546083C (en) 2003-11-11 2014-01-21 Higeta Shoyu Co., Ltd. Novel brevibacillus choshinensis and method for producing protein using the microorganism as host
JP5140307B2 (ja) * 2007-04-10 2013-02-06 花王株式会社 組換え微生物
US8673290B2 (en) * 2011-03-01 2014-03-18 MYGALAXY Limited Company Sporulation-deficient B. texasporus cells and methods for efficient and cost-effective inactivation and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302544A (en) * 1979-10-15 1981-11-24 University Of Rochester Asporogenous mutant of B. subtilis for use as host component of HV1 system
US4465773A (en) * 1982-04-21 1984-08-14 Cpc International Inc. Amylase-negative, asporogenous mutant of Bacillus subtilis useful as a host in a host-vector system
US4450236A (en) * 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of Bacillus subtilis useful as a host in a host-vector system
US4450235A (en) * 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system
IE58099B1 (en) * 1984-06-06 1993-06-30 Cpc International Inc Amylase-negative, asporogenous mutant of bacillus subtilis useful as a host in a host-vector system
JPH0669377B2 (ja) * 1985-11-25 1994-09-07 工業技術院長 Ｄｎａ塩基配列およびベクタ−
GB8727772D0 (en) * 1987-11-27 1987-12-31 Celltech Ltd Host cells
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura

Also Published As

Publication number Publication date
IT1244477B (it) 1994-07-15
JP3013008B2 (ja) 2000-02-28
DK0492274T3 (da) 1995-04-18
IT9022476A0 (it) 1990-12-21
EP0492274B1 (de) 1994-11-17
ATE114171T1 (de) 1994-12-15
US6284490B1 (en) 2001-09-04
ES2074208T3 (es) 1995-09-01
EP0492274A2 (de) 1992-07-01
IT9022476A1 (it) 1992-06-22
JPH04287686A (ja) 1992-10-13
DE69105188T2 (de) 1995-05-18
EP0492274A3 (en) 1993-09-22
GR3014979T3 (en) 1995-05-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PIERREL S.P.A., CAPUA, IT

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA AB, STOCKHOLM, SE

8339 Ceased/non-payment of the annual fee