DE68916915D1 - Heparinase produzierender Mikroorganismus des Stammes Bacillus, neue Heparinase und Verfahren zu ihrer Herstellung. - Google Patents

Heparinase produzierender Mikroorganismus des Stammes Bacillus, neue Heparinase und Verfahren zu ihrer Herstellung.

Info

Publication number
DE68916915D1
DE68916915D1 DE68916915T DE68916915T DE68916915D1 DE 68916915 D1 DE68916915 D1 DE 68916915D1 DE 68916915 T DE68916915 T DE 68916915T DE 68916915 T DE68916915 T DE 68916915T DE 68916915 D1 DE68916915 D1 DE 68916915D1
Authority
DE
Germany
Prior art keywords
heparinase
preparation
new
bacillus strain
producing microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916915T
Other languages
English (en)
Other versions
DE68916915T2 (de
Inventor
Wayne Robert Bellamy
Kouki Horikoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
RIKEN Institute of Physical and Chemical Research
Original Assignee
Research Development Corp of Japan
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Corp of Japan, RIKEN Institute of Physical and Chemical Research filed Critical Research Development Corp of Japan
Publication of DE68916915D1 publication Critical patent/DE68916915D1/de
Application granted granted Critical
Publication of DE68916915T2 publication Critical patent/DE68916915T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE68916915T 1988-11-25 1989-11-22 Heparinase produzierender Mikroorganismus des Stammes Bacillus, neue Heparinase und Verfahren zu ihrer Herstellung. Expired - Fee Related DE68916915T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63297807A JPH0693836B2 (ja) 1988-11-25 1988-11-25 バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法

Publications (2)

Publication Number Publication Date
DE68916915D1 true DE68916915D1 (de) 1994-08-25
DE68916915T2 DE68916915T2 (de) 1994-11-03

Family

ID=17851424

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198989810894T Pending DE370958T1 (de) 1988-11-25 1989-11-22 Heparinase produzierender mikroorganismus des stammes bacillus, neue heparinase und verfahren zu ihrer herstellung.
DE68916915T Expired - Fee Related DE68916915T2 (de) 1988-11-25 1989-11-22 Heparinase produzierender Mikroorganismus des Stammes Bacillus, neue Heparinase und Verfahren zu ihrer Herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198989810894T Pending DE370958T1 (de) 1988-11-25 1989-11-22 Heparinase produzierender mikroorganismus des stammes bacillus, neue heparinase und verfahren zu ihrer herstellung.

Country Status (5)

Country Link
US (3) US5145778A (de)
EP (1) EP0370958B1 (de)
JP (1) JPH0693836B2 (de)
AT (1) ATE108826T1 (de)
DE (2) DE370958T1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0693836B2 (ja) * 1988-11-25 1994-11-24 新技術事業団 バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法
JP3110064B2 (ja) * 1991-03-06 2000-11-20 生化学工業株式会社 新規ヘパリチナーゼ、その製造法及びその生産菌
US5262325A (en) * 1991-04-04 1993-11-16 Ibex Technologies, Inc. Method for the enzymatic neutralization of heparin
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
US6198958B1 (en) 1998-06-11 2001-03-06 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for monitoring a magnetic resonance image during transcranial magnetic stimulation
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
DE60334220D1 (de) * 2002-06-03 2010-10-28 Massachusetts Inst Technology Rationell konstruierte, von chondroitinase b abgeleitete lyasen
US20050277826A1 (en) * 2004-06-10 2005-12-15 Conopco, Inc. Apparatus and method for reducing interference
US7691613B2 (en) 2006-11-03 2010-04-06 Momenta Pharmaceuticals, Inc. Glycosaminoglycan lyase IV and uses thereof
US7767420B2 (en) * 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US7691612B2 (en) 2005-11-03 2010-04-06 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
CN102586217A (zh) * 2011-12-16 2012-07-18 深圳市海普瑞药业股份有限公司 肝素黄杆菌肝素酶ⅰ、ⅱ、ⅲ的冻干保存方法
CN104593347B (zh) * 2015-03-05 2018-08-28 深圳市海普瑞药业集团股份有限公司 来自Sphingobacterium daejeonense的肝素酶及其制备和应用
JP6863626B2 (ja) 2016-12-22 2021-04-21 シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドＳｈｅｎｚｈｅｎ Ｈｅｐａｌｉｎｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． ヘパリナーゼ産生シュードモナス・スタッツェリ株及びそれから得られるヘパリナーゼ
CN113249277B (zh) * 2021-07-05 2021-09-24 广东海洋大学 一株贝雷斯芽孢杆菌在水产品肝素提取中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341869A (en) * 1980-08-25 1982-07-27 Massachusetts Institute Of Technology Process for producing heparinase
JPH0693836B2 (ja) * 1988-11-25 1994-11-24 新技術事業団 バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法

Also Published As

Publication number Publication date
US5455162A (en) 1995-10-03
DE370958T1 (de) 1990-11-08
JPH0693836B2 (ja) 1994-11-24
JPH02142470A (ja) 1990-05-31
US5145778A (en) 1992-09-08
ATE108826T1 (de) 1994-08-15
EP0370958A3 (de) 1991-05-29
EP0370958A2 (de) 1990-05-30
US5362645A (en) 1994-11-08
DE68916915T2 (de) 1994-11-03
EP0370958B1 (de) 1994-07-20

Similar Documents

Publication Publication Date Title
DE68916915D1 (de) Heparinase produzierender Mikroorganismus des Stammes Bacillus, neue Heparinase und Verfahren zu ihrer Herstellung.
ATE131161T1 (de) Substanz pf 1022, verfahren zu ihrer herstellung und diese substanz enthaltende anthelmintische zusammensetzung.
ATE64152T1 (de) Herstellung von staerken des bacillus thuringiensis mit aktivitaet gegen bestimmte lepidoptaere schaedlinge und dadurch erhaltener stamm.
UA32566C2 (uk) Спосіб одержання штаму мікроорганізму, спосіб продукування триптофану
DE69123944D1 (de) Verfahren zur Herstellung von Hydrogengas unter Verwendung von Mikroorganismen
DE68915692D1 (de) Fermentationsverfahren zur Herstellung von 2-Keto-L-Gulonsäure.
CA1266247C (en) ANTIBIOTIC PREPARED BY LYSOBACTER SP. SC14.067
ATE162530T1 (de) 5-methyluridin-verfahren zur herstellung von 2',3'-didehydro-3'-desoxythymidin (d4t) im grossmassstab
DE69030326D1 (de) Zubereitung mit ligninabbauender aktivität, verfahren zu deren herstellung und anwendungen dafür
ATE136541T1 (de) Herstellung substituierter tetrahydropyridine
ATE169679T1 (de) Streptococcus zooepidemicus mutanter stamm zur herstellung von hyaluronsäure
ATE95836T1 (de) Zum abbau von glycosaminoglycan faehige enzymzusammensetzung und verfahren zur herstellung dieser zusammensetzung.
ATE54138T1 (de) Herstellung von cholecalciferolderivaten und neue hierfuer verwendete zwischenprodukte.
ES2023560A6 (es) Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
WO1995021145A3 (en) FERMENTATION PRODUCTION OF LONG CHAIN α,φ-DICARBOXYLIC ACIDS FROM ALKANES BY USE OF A MICROORGANISM
GB9010885D0 (en) A mutant of microbacterium,a strain 851r,and a process for producing 851 nutrient solution by application of the strain
IL83225A (en) Antibiotic a 42867,process for its production and pharmaceutical compositions containing it
ATE153373T1 (de) Mikroorganismen und verfahren zur herstellung von biotin unter verwendung derselben
EP0367598A3 (en) Novel process for the production of 4,6-dimethyl-7-hydroxynonan-3-one
EP0539216A3 (en) Novel microorganisms and a process for preparing 3alpha, 7alpha-dihydroxy-12-keto-5beta-cholanic acid
IL82503A0 (en) Process for the promination of biphenols
TW255916B (en) Production process for flame-retardant polyacrylonitrile fiber
HUT44082A (en) Process for producing 4-androstane-3,17-dion and 1,4-androstadien-3,17-dion
EP0264260A3 (de) Herstellung von polysubstituierten Norbornenen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee