DE69033795T2 - Oberflächenladungsbeschichtung für kapillare elektrophorese - Google Patents
Oberflächenladungsbeschichtung für kapillare elektrophoreseInfo
- Publication number
- DE69033795T2 DE69033795T2 DE69033795T DE69033795T DE69033795T2 DE 69033795 T2 DE69033795 T2 DE 69033795T2 DE 69033795 T DE69033795 T DE 69033795T DE 69033795 T DE69033795 T DE 69033795T DE 69033795 T2 DE69033795 T2 DE 69033795T2
- Authority
- DE
- Germany
- Prior art keywords
- tube
- electroosmotic flow
- surface charge
- capillary electrophoresis
- flow rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44752—Controlling the zeta potential, e.g. by wall coatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/432,061 US5015350A (en) | 1989-11-06 | 1989-11-06 | Flow-rate-controlled surface-charge coating for capillary electrophoresis |
PCT/US1990/006435 WO1991006851A1 (en) | 1989-11-06 | 1990-11-06 | Flow-rate controlled surface charge coating for capillary electrophoresis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69033795D1 DE69033795D1 (de) | 2001-10-18 |
DE69033795T2 true DE69033795T2 (de) | 2002-05-23 |
Family
ID=23714589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69033795T Expired - Lifetime DE69033795T2 (de) | 1989-11-06 | 1990-11-06 | Oberflächenladungsbeschichtung für kapillare elektrophorese |
Country Status (6)
Country | Link |
---|---|
US (1) | US5015350A (de) |
EP (1) | EP0500784B1 (de) |
JP (1) | JP3044481B2 (de) |
AT (1) | ATE205598T1 (de) |
DE (1) | DE69033795T2 (de) |
WO (1) | WO1991006851A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5089106A (en) * | 1986-10-21 | 1992-02-18 | Northeastern University | High performance capillary gel electrophoresis |
US5122248A (en) * | 1990-05-18 | 1992-06-16 | Northeastern University | Pulsed field capillary electrophoresis |
US5332481A (en) | 1991-01-29 | 1994-07-26 | Beckman Instruments, Inc. | Capillary electrophoresis using replaceable gels |
US5212000A (en) * | 1991-03-11 | 1993-05-18 | The Dow Chemical Company | Method for providing an inner-skinned functionalized coating on the lumen-defining surface of a hollow tube |
US5098539A (en) * | 1991-04-19 | 1992-03-24 | Beckman Instruments, Inc. | Gel-containing microcapillary column |
EP0624248B1 (de) * | 1992-01-31 | 1998-04-15 | Beckman Instruments, Inc. | Kapillarsaeule mit einer entfernbaren trenngelzusammensetzung und verfahren zum gebrauch |
US5213669A (en) * | 1992-01-31 | 1993-05-25 | Beckman Instruments, Inc. | Capillary column containing a dynamically cross-linked composition and method of use |
US5296116A (en) * | 1992-06-17 | 1994-03-22 | Beckman Instruments, Inc. | Capillary electrophoresis using time-varying field strength |
US5302264A (en) * | 1992-09-02 | 1994-04-12 | Scientronix, Inc. | Capillary eletrophoresis method and apparatus |
US5286356A (en) * | 1993-01-21 | 1994-02-15 | Millipore Corporation | Method for sample analysis using capillary electrophoresis |
US5415747A (en) * | 1993-08-16 | 1995-05-16 | Hewlett-Packard Company | Capillary electrophoresis using zwitterion-coated capillary tubes |
US5342492A (en) * | 1993-09-01 | 1994-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | System for electrokinetic separation and detection where detection is performed at other than separation electric field |
US5462646A (en) * | 1993-09-29 | 1995-10-31 | Beckman Instruments, Inc. | Coated capillary columns and electrophoretic separation methods for their use |
US6358385B1 (en) * | 1993-12-17 | 2002-03-19 | The Perkin-Elmer Corporation | Polymers for separation of biomolecules by capillary electrophoresis |
WO1995016910A1 (en) * | 1993-12-17 | 1995-06-22 | Perkin-Elmer Corporation | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
US5423966A (en) * | 1994-01-25 | 1995-06-13 | Perkin-Elmer Corporation | On line ion contaminant removal apparatus and method for capillary electrophoresis |
US5573651A (en) * | 1995-04-17 | 1996-11-12 | The Dow Chemical Company | Apparatus and method for flow injection analysis |
US5578179A (en) * | 1995-07-12 | 1996-11-26 | The Perkin-Elmer Corporation | Method and silicate composition for conditioning silica surfaces |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
SE9602638D0 (sv) * | 1996-07-03 | 1996-07-03 | Pharmacia Biotech Ab | An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds |
US6110343A (en) * | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus |
EP1022562B1 (de) * | 1996-12-03 | 2007-08-15 | Eisai R&D Management Co., Ltd. | Kapillare mit beschichteter innenwand |
US5976336A (en) * | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
US7033474B1 (en) | 1997-04-25 | 2006-04-25 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
CN1105914C (zh) * | 1997-04-25 | 2003-04-16 | 卡钳技术有限公司 | 改进了通道几何结构的微型流体装置 |
US6224830B1 (en) * | 1998-01-30 | 2001-05-01 | The Governors Of The University Of Alberta | Absorbance cell for microfluid devices |
US6537432B1 (en) | 1998-02-24 | 2003-03-25 | Target Discovery, Inc. | Protein separation via multidimensional electrophoresis |
US6706161B1 (en) * | 1998-06-10 | 2004-03-16 | Agilent Technologies, Inc. | Methods and compositions for modifying the surface of a polymeric substrate |
JP4515640B2 (ja) | 1999-02-02 | 2010-08-04 | カリパー・ライフ・サイエンシズ・インク. | タンパク質特性決定方法、装置及びシステム |
US6306273B1 (en) | 1999-04-13 | 2001-10-23 | Aclara Biosciences, Inc. | Methods and compositions for conducting processes in microfluidic devices |
US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US6818112B2 (en) * | 1999-04-20 | 2004-11-16 | Target Discovery, Inc. | Protein separation via multidimensional electrophoresis |
US6706162B1 (en) | 2000-09-25 | 2004-03-16 | Applera Corporation | High speed, high resolution compositions, methods, and kits for capillary electrophoresis |
AU2002330918A1 (en) * | 2001-07-24 | 2003-02-17 | Biomics, Inc. | High performance wide bore electrophoresis |
WO2003073233A2 (en) * | 2002-02-26 | 2003-09-04 | Pharmacia Corporation | Sequence detection system calculator |
US7381317B2 (en) * | 2002-08-12 | 2008-06-03 | Beckman Coulter, Inc. | Methods and compositions for capillary electrophoresis (CE) |
US20040115830A1 (en) * | 2002-09-25 | 2004-06-17 | Igor Touzov | Components for nano-scale Reactor |
US20050025741A1 (en) | 2003-05-15 | 2005-02-03 | Lau Aldrich N.K. | Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis |
JP4450368B2 (ja) | 2004-03-04 | 2010-04-14 | 独立行政法人産業技術総合研究所 | マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置 |
US20070014699A1 (en) | 2005-06-23 | 2007-01-18 | Beckman Coulter, Inc, | Methods and apparatus for improving the sensitivity of capillary zone electrophoresis |
CN100389323C (zh) * | 2005-07-22 | 2008-05-21 | 中国科学院上海有机化学研究所 | 毛细管电泳酶微反应器的制备方法和用途 |
US9121821B2 (en) | 2006-09-04 | 2015-09-01 | National Institute Of Advanced Industrial Science And Technology | Process for analyzing sample by capillary electrophoresis method |
WO2008029685A1 (fr) | 2006-09-04 | 2008-03-13 | National Institute Of Advanced Industrial Science And Technology | Procédé pour analyse d'échantillon par électrophorèse capillaire |
US9244011B2 (en) | 2011-11-16 | 2016-01-26 | Luna Innovations Incorporated | Method and apparatus for OFDR-based electrophoresis |
CN103018310A (zh) * | 2012-12-14 | 2013-04-03 | 凯晶生物科技(苏州)有限公司 | 用于实现多次进样的毛细管芯片电泳结构及其实现方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3909380A (en) * | 1974-07-19 | 1975-09-30 | Komline Sanderson Eng Corp | Reference pattern zeta potential measurement apparatus and method therefor |
FR2580812B1 (fr) * | 1985-04-22 | 1988-04-22 | Univ Caen | Procede pour attenuer ou supprimer le phenomene d'electro-osmose dans une cellule d'electrophorese et cellule d'electrophorese ainsi obtenue |
US4680201A (en) * | 1985-10-30 | 1987-07-14 | Stellan Hjerten | Coating for electrophoresis tube |
US4690749A (en) * | 1985-12-16 | 1987-09-01 | Universities Space Research Association | Polymer-coated surfaces to control surface zeta potential |
US4865707A (en) * | 1986-10-21 | 1989-09-12 | Northeastern University | Capillary gel electrophoresis columns |
US4865706A (en) * | 1986-10-21 | 1989-09-12 | Northeastern University | High performance microcapillary gel electrophoresis |
-
1989
- 1989-11-06 US US07/432,061 patent/US5015350A/en not_active Expired - Lifetime
-
1990
- 1990-11-06 DE DE69033795T patent/DE69033795T2/de not_active Expired - Lifetime
- 1990-11-06 JP JP2515884A patent/JP3044481B2/ja not_active Expired - Fee Related
- 1990-11-06 WO PCT/US1990/006435 patent/WO1991006851A1/en active IP Right Grant
- 1990-11-06 EP EP91900595A patent/EP0500784B1/de not_active Expired - Lifetime
- 1990-11-06 AT AT91900595T patent/ATE205598T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE205598T1 (de) | 2001-09-15 |
JP3044481B2 (ja) | 2000-05-22 |
WO1991006851A1 (en) | 1991-05-16 |
DE69033795D1 (de) | 2001-10-18 |
US5015350A (en) | 1991-05-14 |
JPH05503989A (ja) | 1993-06-24 |
EP0500784A1 (de) | 1992-09-02 |
EP0500784B1 (de) | 2001-09-12 |
EP0500784A4 (en) | 1993-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLERA CORP., FOSTER CITY, CALIF., US |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT AUFGEHOBEN |