DE69033795T2 - Oberflächenladungsbeschichtung für kapillare elektrophorese - Google Patents

Oberflächenladungsbeschichtung für kapillare elektrophorese

Info

Publication number
DE69033795T2
DE69033795T2 DE69033795T DE69033795T DE69033795T2 DE 69033795 T2 DE69033795 T2 DE 69033795T2 DE 69033795 T DE69033795 T DE 69033795T DE 69033795 T DE69033795 T DE 69033795T DE 69033795 T2 DE69033795 T2 DE 69033795T2
Authority
DE
Germany
Prior art keywords
tube
electroosmotic flow
surface charge
capillary electrophoresis
flow rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69033795T
Other languages
English (en)
Other versions
DE69033795D1 (de
Inventor
E Wiktorowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
PE Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PE Corp filed Critical PE Corp
Publication of DE69033795D1 publication Critical patent/DE69033795D1/de
Application granted granted Critical
Publication of DE69033795T2 publication Critical patent/DE69033795T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44752—Controlling the zeta potential, e.g. by wall coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DE69033795T 1989-11-06 1990-11-06 Oberflächenladungsbeschichtung für kapillare elektrophorese Expired - Lifetime DE69033795T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/432,061 US5015350A (en) 1989-11-06 1989-11-06 Flow-rate-controlled surface-charge coating for capillary electrophoresis
PCT/US1990/006435 WO1991006851A1 (en) 1989-11-06 1990-11-06 Flow-rate controlled surface charge coating for capillary electrophoresis

Publications (2)

Publication Number Publication Date
DE69033795D1 DE69033795D1 (de) 2001-10-18
DE69033795T2 true DE69033795T2 (de) 2002-05-23

Family

ID=23714589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033795T Expired - Lifetime DE69033795T2 (de) 1989-11-06 1990-11-06 Oberflächenladungsbeschichtung für kapillare elektrophorese

Country Status (6)

Country Link
US (1) US5015350A (de)
EP (1) EP0500784B1 (de)
JP (1) JP3044481B2 (de)
AT (1) ATE205598T1 (de)
DE (1) DE69033795T2 (de)
WO (1) WO1991006851A1 (de)

Families Citing this family (45)

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US5089106A (en) * 1986-10-21 1992-02-18 Northeastern University High performance capillary gel electrophoresis
US5122248A (en) * 1990-05-18 1992-06-16 Northeastern University Pulsed field capillary electrophoresis
US5332481A (en) 1991-01-29 1994-07-26 Beckman Instruments, Inc. Capillary electrophoresis using replaceable gels
US5212000A (en) * 1991-03-11 1993-05-18 The Dow Chemical Company Method for providing an inner-skinned functionalized coating on the lumen-defining surface of a hollow tube
US5098539A (en) * 1991-04-19 1992-03-24 Beckman Instruments, Inc. Gel-containing microcapillary column
US5213669A (en) * 1992-01-31 1993-05-25 Beckman Instruments, Inc. Capillary column containing a dynamically cross-linked composition and method of use
EP0624248B1 (de) * 1992-01-31 1998-04-15 Beckman Instruments, Inc. Kapillarsaeule mit einer entfernbaren trenngelzusammensetzung und verfahren zum gebrauch
US5296116A (en) * 1992-06-17 1994-03-22 Beckman Instruments, Inc. Capillary electrophoresis using time-varying field strength
US5302264A (en) * 1992-09-02 1994-04-12 Scientronix, Inc. Capillary eletrophoresis method and apparatus
US5286356A (en) * 1993-01-21 1994-02-15 Millipore Corporation Method for sample analysis using capillary electrophoresis
US5415747A (en) * 1993-08-16 1995-05-16 Hewlett-Packard Company Capillary electrophoresis using zwitterion-coated capillary tubes
US5342492A (en) * 1993-09-01 1994-08-30 The Board Of Trustees Of The Leland Stanford Junior University System for electrokinetic separation and detection where detection is performed at other than separation electric field
US5462646A (en) * 1993-09-29 1995-10-31 Beckman Instruments, Inc. Coated capillary columns and electrophoretic separation methods for their use
AU1254295A (en) * 1993-12-17 1995-07-03 Perkin-Elmer Corporation, The Uncharged polymers for separation of biomolecules by capillary electrophoresis
US6358385B1 (en) * 1993-12-17 2002-03-19 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
US5423966A (en) * 1994-01-25 1995-06-13 Perkin-Elmer Corporation On line ion contaminant removal apparatus and method for capillary electrophoresis
US5573651A (en) * 1995-04-17 1996-11-12 The Dow Chemical Company Apparatus and method for flow injection analysis
US5578179A (en) 1995-07-12 1996-11-26 The Perkin-Elmer Corporation Method and silicate composition for conditioning silica surfaces
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
SE9602638D0 (sv) * 1996-07-03 1996-07-03 Pharmacia Biotech Ab An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds
US6110343A (en) * 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
EP1022562B1 (de) * 1996-12-03 2007-08-15 Eisai R&D Management Co., Ltd. Kapillare mit beschichteter innenwand
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
EP0988529B1 (de) * 1997-04-25 2013-06-12 Caliper Life Sciences, Inc. Mikrofluidische geräte mit verbesserten kanalgeometrien
US6224830B1 (en) * 1998-01-30 2001-05-01 The Governors Of The University Of Alberta Absorbance cell for microfluid devices
US6537432B1 (en) 1998-02-24 2003-03-25 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6706161B1 (en) * 1998-06-10 2004-03-16 Agilent Technologies, Inc. Methods and compositions for modifying the surface of a polymeric substrate
EP2278320B1 (de) 1999-02-02 2018-07-18 Caliper Life Sciences, Inc. Verfahren und Vorrichtungen zur Charakterisierung von Proteinen
US6306273B1 (en) 1999-04-13 2001-10-23 Aclara Biosciences, Inc. Methods and compositions for conducting processes in microfluidic devices
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6818112B2 (en) * 1999-04-20 2004-11-16 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6706162B1 (en) 2000-09-25 2004-03-16 Applera Corporation High speed, high resolution compositions, methods, and kits for capillary electrophoresis
WO2003010528A1 (en) * 2001-07-24 2003-02-06 Biomics, Inc. High performance wide bore electrophoresis
JP2006505832A (ja) * 2002-02-26 2006-02-16 フアルマシア・コーポレーシヨン 配列決定システム計算機
US7381317B2 (en) * 2002-08-12 2008-06-03 Beckman Coulter, Inc. Methods and compositions for capillary electrophoresis (CE)
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US20050025741A1 (en) 2003-05-15 2005-02-03 Lau Aldrich N.K. Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis
JP4450368B2 (ja) 2004-03-04 2010-04-14 独立行政法人産業技術総合研究所 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
CN100389323C (zh) * 2005-07-22 2008-05-21 中国科学院上海有机化学研究所 毛细管电泳酶微反应器的制备方法和用途
EP2060912B1 (de) 2006-09-04 2014-10-01 National Institute of Advanced Industrial Science and Technology Verfahren zur analyse einer probe mittels kapillarelektrophorese
WO2008029685A1 (fr) 2006-09-04 2008-03-13 National Institute Of Advanced Industrial Science And Technology Procédé pour analyse d'échantillon par électrophorèse capillaire
WO2013074314A1 (en) * 2011-11-16 2013-05-23 Luna Innovations Incorporated Method and apparatus for ofdr-based electrophoresis
CN103018310A (zh) * 2012-12-14 2013-04-03 凯晶生物科技(苏州)有限公司 用于实现多次进样的毛细管芯片电泳结构及其实现方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3909380A (en) * 1974-07-19 1975-09-30 Komline Sanderson Eng Corp Reference pattern zeta potential measurement apparatus and method therefor
FR2580812B1 (fr) * 1985-04-22 1988-04-22 Univ Caen Procede pour attenuer ou supprimer le phenomene d'electro-osmose dans une cellule d'electrophorese et cellule d'electrophorese ainsi obtenue
US4680201A (en) * 1985-10-30 1987-07-14 Stellan Hjerten Coating for electrophoresis tube
US4690749A (en) * 1985-12-16 1987-09-01 Universities Space Research Association Polymer-coated surfaces to control surface zeta potential
US4865706A (en) * 1986-10-21 1989-09-12 Northeastern University High performance microcapillary gel electrophoresis
US4865707A (en) * 1986-10-21 1989-09-12 Northeastern University Capillary gel electrophoresis columns

Also Published As

Publication number Publication date
EP0500784B1 (de) 2001-09-12
ATE205598T1 (de) 2001-09-15
JPH05503989A (ja) 1993-06-24
US5015350A (en) 1991-05-14
EP0500784A1 (de) 1992-09-02
EP0500784A4 (en) 1993-03-17
JP3044481B2 (ja) 2000-05-22
DE69033795D1 (de) 2001-10-18
WO1991006851A1 (en) 1991-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: APPLERA CORP., FOSTER CITY, CALIF., US

8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8380 Miscellaneous part iii

Free format text: PFANDRECHT

8380 Miscellaneous part iii

Free format text: PFANDRECHT AUFGEHOBEN