DE69032467T2 - Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase - Google Patents

Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase

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Publication number
DE69032467T2
DE69032467T2 DE69032467T DE69032467T DE69032467T2 DE 69032467 T2 DE69032467 T2 DE 69032467T2 DE 69032467 T DE69032467 T DE 69032467T DE 69032467 T DE69032467 T DE 69032467T DE 69032467 T2 DE69032467 T2 DE 69032467T2
Authority
DE
Germany
Prior art keywords
water
acenylase
reaction medium
controlled conditions
contains organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69032467T
Other languages
English (en)
Other versions
DE69032467D1 (de
Inventor
Seijas Jose Guisan
Roberto Ins Fernandez-Lafuente
Campos Gregorio Instit Alvaro
Martin Rosa Blanco
Rosell Cristina Instit Molina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8265139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69032467(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Application granted granted Critical
Publication of DE69032467D1 publication Critical patent/DE69032467D1/de
Publication of DE69032467T2 publication Critical patent/DE69032467T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69032467T 1989-12-12 1990-12-12 Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase Expired - Fee Related DE69032467T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES8904193A ES2036149A6 (es) 1989-12-12 1989-12-12 Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
PCT/ES1990/000046 WO1991009136A1 (es) 1989-12-12 1990-12-12 Procedimiento de sintesis de antibioticos semisinteticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa

Publications (2)

Publication Number Publication Date
DE69032467D1 DE69032467D1 (de) 1998-08-13
DE69032467T2 true DE69032467T2 (de) 1999-01-14

Family

ID=8265139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69032467T Expired - Fee Related DE69032467T2 (de) 1989-12-12 1990-12-12 Verfahren zur herstellung von semisynthetischen antibiotika unter thermodynamisch kontrollierten bedingungen, in einem reaktionsmedium, das organische apolare wasserlösliche lösungsmittel enthält unter verwendung von penicillin g-acylase

Country Status (7)

Country Link
US (1) US5268271A (de)
EP (1) EP0458932B2 (de)
AT (1) ATE168134T1 (de)
AU (1) AU6960291A (de)
DE (1) DE69032467T2 (de)
ES (1) ES2036149A6 (de)
WO (1) WO1991009136A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA915142B (en) * 1990-07-04 1992-05-27 Novo Nordisk As Process for preparation of beta-lactams
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
AU2881595A (en) * 1994-06-10 1996-01-05 Gist-Brocades B.V. Improved acylation method for penicillins and cephalosporins
DE69512917D1 (de) * 1994-07-18 1999-11-25 Dsm Nv Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
ATE191932T1 (de) * 1995-02-28 2000-05-15 Acs Dobfar Spa Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor
EP1394262A1 (de) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen
BRPI0205242B1 (pt) * 2002-11-29 2015-06-30 Fundação Universidade Fed De São Carlos Processo para a proteção de biocatalisadores enzimáticos insolúveis, biocatalisador obtido e biorreator com o biocatalisador imobilizado
NO329007B1 (no) * 2008-05-19 2010-07-19 Tor Mikal Ostervold Fremgangsmate og apparat til rengjoring av flater

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT233739B (de) * 1962-02-14 1964-05-25 Biochemie Gmbh Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin
ES396745A1 (es) * 1970-11-07 1974-06-01 Alfa Farmaceutici Spa Procedimiento enzimatico para la preparacion de penicili- nas semisinteticas.
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
US3925157A (en) * 1972-07-12 1975-12-09 Pfizer Immobilized enzymes
JPS5417030B2 (de) * 1972-12-06 1979-06-27
US4167446A (en) * 1973-03-15 1979-09-11 Bayer Aktiengesellschaft Water soluble carrier-bound penicillinacylase
GB1463513A (en) * 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
GB2021119A (en) * 1978-04-19 1979-11-28 Novo Industri As Penicillin V-acylase
JPS5645196A (en) * 1979-09-19 1981-04-24 Shionogi & Co Ltd Enzymatic synthesis of beta-lactam antibacterial agent
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
JPS6066981A (ja) * 1983-09-12 1985-04-17 アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン 不溶化ペニシリンアミダ−ゼおよびその製法
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
IT1224252B (it) * 1988-04-08 1990-09-26 Sclavo Spa Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme

Also Published As

Publication number Publication date
US5268271A (en) 1993-12-07
ES2036149A6 (es) 1993-05-01
DE69032467D1 (de) 1998-08-13
EP0458932A1 (de) 1991-12-04
AU6960291A (en) 1991-07-18
EP0458932B1 (de) 1998-07-08
EP0458932B2 (de) 2003-12-17
WO1991009136A1 (es) 1991-06-27
ATE168134T1 (de) 1998-07-15

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8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee