AT233739B - Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin - Google Patents
Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von PhenoxymethylpenicillinInfo
- Publication number
- AT233739B AT233739B AT125062A AT125062A AT233739B AT 233739 B AT233739 B AT 233739B AT 125062 A AT125062 A AT 125062A AT 125062 A AT125062 A AT 125062A AT 233739 B AT233739 B AT 233739B
- Authority
- AT
- Austria
- Prior art keywords
- phenoxymethylpenicillin
- fusarium
- yeast
- preparation
- enzymatic cleavage
- Prior art date
Links
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 title 1
- 241000223218 Fusarium Species 0.000 title 1
- 229930195708 Penicillin V Natural products 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229940056367 penicillin v Drugs 0.000 title 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/42—Compounds with a free primary amino radical attached in position 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/929—Fusarium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT125062A AT233739B (de) | 1962-02-14 | 1962-02-14 | Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin |
| DE1963B0070633 DE1445488B2 (de) | 1962-02-14 | 1963-02-05 | Verfahren zur herstellung von 6- aminopenicillansaeure |
| SE1471/63A SE323077B (de) | 1962-02-14 | 1963-02-11 | |
| US257858A US3337415A (en) | 1962-02-14 | 1963-02-12 | Method of preparing 6-amino-penicillanic acid |
| GB56171/63A GB961517A (en) | 1962-02-14 | 1963-02-12 | Process of producing 6-aminopenicillanic acid |
| DK69463*BA DK131500C (da) | 1962-02-14 | 1963-02-14 | Fremgangsmade til fremstilling af 6-aminopenicillansyre |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT125062A AT233739B (de) | 1962-02-14 | 1962-02-14 | Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT233739B true AT233739B (de) | 1964-05-25 |
Family
ID=3509837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT125062A AT233739B (de) | 1962-02-14 | 1962-02-14 | Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3337415A (de) |
| AT (1) | AT233739B (de) |
| DE (1) | DE1445488B2 (de) |
| DK (1) | DK131500C (de) |
| GB (1) | GB961517A (de) |
| SE (1) | SE323077B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5510238B2 (de) * | 1973-05-30 | 1980-03-14 | ||
| ES2036149A6 (es) * | 1989-12-12 | 1993-05-01 | Consejo Superior Investigacion | Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. |
| US5516679A (en) * | 1994-12-23 | 1996-05-14 | Bristol-Myers Squibb Company | Penicillin V amidohydrolase gene from Fusarium oxysporum |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB891173A (en) * | 1959-05-06 | 1962-03-14 | Knud Abildgaard | Method for the production of 6-amino-penicillanic acid |
| US3014846A (en) * | 1960-01-25 | 1961-12-26 | Rolinson George Newbolt | Production of 6-aminopenicillanic acid |
| US3070511A (en) * | 1960-02-10 | 1962-12-25 | Lepetit Spa | Process for preparing 6-aminopenicillanic acid |
| US3032473A (en) * | 1961-03-14 | 1962-05-01 | American Home Prod | Preparation of 6-aminopenicillanic acid by enzymatic hydrolysis |
-
1962
- 1962-02-14 AT AT125062A patent/AT233739B/de active
-
1963
- 1963-02-05 DE DE1963B0070633 patent/DE1445488B2/de active Granted
- 1963-02-11 SE SE1471/63A patent/SE323077B/xx unknown
- 1963-02-12 US US257858A patent/US3337415A/en not_active Expired - Lifetime
- 1963-02-12 GB GB56171/63A patent/GB961517A/en not_active Expired
- 1963-02-14 DK DK69463*BA patent/DK131500C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK131500C (da) | 1976-02-16 |
| US3337415A (en) | 1967-08-22 |
| GB961517A (en) | 1964-06-24 |
| DE1445488B2 (de) | 1976-07-22 |
| SE323077B (de) | 1970-04-27 |
| DK131500B (da) | 1975-07-28 |
| DE1445488A1 (de) | 1968-11-14 |
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