DE69031187D1 - Verfahren für die Racemattrennung von Zwischenprodukten, die bei der Herstellung von 1,5-Benzothiazepinen verwendbar sind - Google Patents

Verfahren für die Racemattrennung von Zwischenprodukten, die bei der Herstellung von 1,5-Benzothiazepinen verwendbar sind

Info

Publication number
DE69031187D1
DE69031187D1 DE69031187T DE69031187T DE69031187D1 DE 69031187 D1 DE69031187 D1 DE 69031187D1 DE 69031187 T DE69031187 T DE 69031187T DE 69031187 T DE69031187 T DE 69031187T DE 69031187 D1 DE69031187 D1 DE 69031187D1
Authority
DE
Germany
Prior art keywords
resolution
intermediates
benzothiazepines
production
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69031187T
Other languages
English (en)
Other versions
DE69031187T2 (de
Inventor
Dario Tentorio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE69031187D1 publication Critical patent/DE69031187D1/de
Publication of DE69031187T2 publication Critical patent/DE69031187T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69031187T 1989-04-13 1990-04-12 Verfahren für die Racemattrennung von Zwischenprodukten, die bei der Herstellung von 1,5-Benzothiazepinen verwendbar sind Expired - Fee Related DE69031187T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920134A IT1230057B (it) 1989-04-13 1989-04-13 Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine

Publications (2)

Publication Number Publication Date
DE69031187D1 true DE69031187D1 (de) 1997-09-11
DE69031187T2 DE69031187T2 (de) 1998-01-22

Family

ID=11164095

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69031187T Expired - Fee Related DE69031187T2 (de) 1989-04-13 1990-04-12 Verfahren für die Racemattrennung von Zwischenprodukten, die bei der Herstellung von 1,5-Benzothiazepinen verwendbar sind
DE69033315T Expired - Fee Related DE69033315T2 (de) 1989-04-13 1990-04-12 Verfahren zur Herstellung von 1,5-Benzothiazepinen durch Ringschluss von Aminoestern

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69033315T Expired - Fee Related DE69033315T2 (de) 1989-04-13 1990-04-12 Verfahren zur Herstellung von 1,5-Benzothiazepinen durch Ringschluss von Aminoestern

Country Status (9)

Country Link
US (1) US5144025A (de)
EP (2) EP0669327B1 (de)
JP (1) JP2979237B2 (de)
AT (2) ATE156484T1 (de)
DE (2) DE69031187T2 (de)
DK (2) DK0669327T3 (de)
ES (2) ES2106724T3 (de)
GR (2) GR3025188T3 (de)
IT (1) IT1230057B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234387B (it) * 1989-07-12 1992-05-18 Zambon Spa Processo di purificazione di intermedi utili nella preparazione del diltiazem
US4963671A (en) * 1989-11-20 1990-10-16 E. R. Squibb & Sons, Inc. Process for resolving chiral intermediates used in making calcium channel blockers
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法
EP0778272B1 (de) * 1995-12-05 1998-12-23 Tanabe Seiyaku Co., Ltd. Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
DE10142564A1 (de) 2000-09-30 2002-04-11 Zeiss Carl Stativ
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
CN101532094B (zh) * 2008-03-11 2010-07-28 江西稀有稀土金属钨业集团有限公司 从钙和镁杂质含量高的酸性原料体系中全程萃取分离得到镍和钴的工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
US4594342A (en) * 1984-04-10 1986-06-10 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivative
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
EP0322779A3 (de) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
US4963671A (en) * 1989-11-20 1990-10-16 E. R. Squibb & Sons, Inc. Process for resolving chiral intermediates used in making calcium channel blockers
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法

Also Published As

Publication number Publication date
ATE185343T1 (de) 1999-10-15
ES2106724T3 (es) 1997-11-16
DK0669327T3 (da) 2000-04-10
EP0392543A1 (de) 1990-10-17
DE69033315D1 (de) 1999-11-11
GR3025188T3 (en) 1998-02-27
US5144025A (en) 1992-09-01
ES2138100T3 (es) 2000-01-01
IT8920134A0 (it) 1989-04-13
IT1230057B (it) 1991-09-27
EP0669327A1 (de) 1995-08-30
JPH03115273A (ja) 1991-05-16
DE69031187T2 (de) 1998-01-22
ATE156484T1 (de) 1997-08-15
DE69033315T2 (de) 2000-04-13
JP2979237B2 (ja) 1999-11-15
EP0392543B1 (de) 1997-08-06
EP0669327B1 (de) 1999-10-06
DK0392543T3 (da) 1997-09-15
GR3032027T3 (en) 2000-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee