DE69015361D1 - Lichtaktivierte acylenzyme. - Google Patents

Lichtaktivierte acylenzyme.

Info

Publication number
DE69015361D1
DE69015361D1 DE69015361T DE69015361T DE69015361D1 DE 69015361 D1 DE69015361 D1 DE 69015361D1 DE 69015361 T DE69015361 T DE 69015361T DE 69015361 T DE69015361 T DE 69015361T DE 69015361 D1 DE69015361 D1 DE 69015361D1
Authority
DE
Germany
Prior art keywords
unconjugated
acyl
enzymes
alkyl
light activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015361T
Other languages
English (en)
Other versions
DE69015361T2 (de
Inventor
Ned Porter
John Bruhnke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Application granted granted Critical
Publication of DE69015361D1 publication Critical patent/DE69015361D1/de
Publication of DE69015361T2 publication Critical patent/DE69015361T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/44—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69015361T 1989-08-29 1990-08-27 Lichtaktivierte acylenzyme. Expired - Fee Related DE69015361T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/400,507 US5114851A (en) 1989-08-29 1989-08-29 Light activated acyl-enzymes
PCT/US1990/004872 WO1991003549A1 (en) 1989-08-29 1990-08-27 Light activated acyl-enzymes

Publications (2)

Publication Number Publication Date
DE69015361D1 true DE69015361D1 (de) 1995-02-02
DE69015361T2 DE69015361T2 (de) 1995-06-22

Family

ID=23583888

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015361T Expired - Fee Related DE69015361T2 (de) 1989-08-29 1990-08-27 Lichtaktivierte acylenzyme.

Country Status (11)

Country Link
US (1) US5114851A (de)
EP (1) EP0489836B1 (de)
JP (1) JP2839371B2 (de)
KR (1) KR100192004B1 (de)
AT (1) ATE116000T1 (de)
AU (1) AU636269B2 (de)
CA (1) CA2065008C (de)
DE (1) DE69015361T2 (de)
DK (1) DK0489836T3 (de)
ES (1) ES2067044T3 (de)
WO (1) WO1991003549A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583107A (en) * 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
SG93823A1 (en) * 1998-02-13 2003-01-21 Givaudan Roure Int Aryl-acrylic acid esters
US6229020B1 (en) 1999-01-12 2001-05-08 Laboratory Of Molecular Biophotonics Reagents for preparation of caged compounds, and method for preparation of the caged compounds
US6329546B1 (en) 1999-01-12 2001-12-11 Laboratory Of Molecular Biophotonics Caged amino acids
US7157458B2 (en) * 2001-04-17 2007-01-02 Cryolife, Inc. Bifunctional energy-reversible acyl-compositions
US6774116B2 (en) * 2001-04-17 2004-08-10 Cryolife, Inc. Prodrugs via acylation with cinnamate
EP1404643A4 (de) 2001-05-29 2008-05-07 Univ Vanderbilt Spaltbare tenside und verfahren zu deren verwendung
JP4750360B2 (ja) 2001-10-22 2011-08-17 ザ スクリプス リサーチ インスティチュート 抗体ターゲッティング化合物
WO2003034995A2 (en) 2001-10-22 2003-05-01 The Scripps Research Institute Integrin targeting compounds
CA2630415A1 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
TWI311679B (en) * 2006-04-28 2009-07-01 Primax Electronics Ltd A method of evaluating minimum sampling steps of auto focus
JP5008578B2 (ja) 2008-01-28 2012-08-22 株式会社リコー 画像処理方法、画像処理装置及び画像撮像装置
US20100068153A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo activatable final dosage form
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100068152A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable particle or polymeric based final dosage form
US20100068235A1 (en) * 2008-09-16 2010-03-18 Searete LLC, a limited liability corporation of Deleware Individualizable dosage form
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US8753677B2 (en) * 2008-09-16 2014-06-17 The Invention Science Fund I, Llc Ex vivo modifiable multiple medicament final dosage form

Also Published As

Publication number Publication date
DE69015361T2 (de) 1995-06-22
KR100192004B1 (ko) 1999-06-15
JPH05500004A (ja) 1993-01-14
AU6331990A (en) 1991-04-08
WO1991003549A1 (en) 1991-03-21
ES2067044T3 (es) 1995-03-16
EP0489836A1 (de) 1992-06-17
ATE116000T1 (de) 1995-01-15
DK0489836T3 (da) 1995-06-06
EP0489836B1 (de) 1994-12-21
CA2065008C (en) 1995-08-01
CA2065008A1 (en) 1991-03-01
EP0489836A4 (en) 1993-05-26
JP2839371B2 (ja) 1998-12-16
US5114851A (en) 1992-05-19
KR927003805A (ko) 1992-12-18
AU636269B2 (en) 1993-04-22

Similar Documents

Publication Publication Date Title
DE69015361T2 (de) Lichtaktivierte acylenzyme.
AR038429A2 (es) Compuestos 15-alquil-16-hidroxilo de marcfortina
DK0519327T3 (da) N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt
DK0609960T3 (da) Nye N-heteroarylamidderivater som inhibitorer af acylcoenzym-A: cholesterolacyltransferase
CO4700469A1 (es) 3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion .
SE8404019D0 (sv) Oftalmiskt medel
FI792005A (fi) 2-(2-alkoxietyl)-2'-hydroxi-6,7-benzomorfaner deras syraadditionssalter dessa innehaollande laekemedel och foerfarande foer deras framstaellning
ES2058173T3 (es) Dioxialquilenaril-dihidropiridinas, productos intermedios para su fabricacion, procedimientos para su fabricacion y su utilizacion.
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
DK0532515T3 (da) Fremstilling af substituerede piperidiner
DK0565558T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af azabicyclo(2.2.2)octan-3-iminer
ES2039272T3 (es) Sales opticamente activas a base de un tiazolidin-4-carboxilato sustituido y 3-cloro-2-hidroxipropiltrimetilamonio, su preparacion y empleo.
ES2194102T3 (es) Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
DE59010545D1 (de) Phosphinesterhaltige N-Acyl-2-aminosäureamide, Verfahren zu ihrer Herstellung und N-Acyl-2-aminosäurenitrile als Vorprodukte
DK1205476T3 (da) Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer
BR9107112A (pt) Controle de nematodeos(a) parasilticos
ES2039364T3 (es) Derivados de n - ariltetrahidroftalimida y sus productos previos.
DK325985D0 (da) Substituerede 5-amino-1-phenylpyrazoler, deres fremstilling og anvendelse som herbicide midler, samt ved fremstillingen anvendeligt udgangsprodukt og fremstilling deraf
EA199900888A1 (ru) Противоревматические средства
FI962768A0 (fi) N-(2-ftaali-imidoetyyli)substituoituja transpiperidiini-2,5-dikarboksylaatteja
DK316589A (da) Substituerede azacyclohexylderivater af rifamyciner
ES2186127T3 (es) Sintesis de derivados de nucleosidos aciclicos.
FI930092A0 (fi) Indanopyrrolidinkarbamater
ES2181858T3 (es) Procedimiento de preparacion de (met)acrilato de alquilimidazolidona.
DK0492350T3 (da) Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee