DE69015208D1 - Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung. - Google Patents

Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung.

Info

Publication number
DE69015208D1
DE69015208D1 DE69015208T DE69015208T DE69015208D1 DE 69015208 D1 DE69015208 D1 DE 69015208D1 DE 69015208 T DE69015208 T DE 69015208T DE 69015208 T DE69015208 T DE 69015208T DE 69015208 D1 DE69015208 D1 DE 69015208D1
Authority
DE
Germany
Prior art keywords
group
chloro
derivatives
hydrogen
antigastrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015208T
Other languages
English (en)
Other versions
DE69015208T2 (de
Inventor
Francesco Makovec
Claudio Rovati
Angelo Rovati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Application granted granted Critical
Publication of DE69015208D1 publication Critical patent/DE69015208D1/de
Publication of DE69015208T2 publication Critical patent/DE69015208T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69015208T 1989-11-02 1990-10-25 Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung. Expired - Fee Related DE69015208T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT67937A IT1238664B (it) 1989-11-02 1989-11-02 Derivati degli acidi glutammico ed aspartico ad attivita' antigastrinica e procedimento per la loro preparazione
PCT/EP1990/001808 WO1991006529A1 (en) 1989-11-02 1990-10-25 Glutamic and aspartic acid derivatives with antigastrin activity and a method for their preparation

Publications (2)

Publication Number Publication Date
DE69015208D1 true DE69015208D1 (de) 1995-01-26
DE69015208T2 DE69015208T2 (de) 1995-05-04

Family

ID=11306521

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015208T Expired - Fee Related DE69015208T2 (de) 1989-11-02 1990-10-25 Glutamin- und asparginsäurederivate mit antigastrinwirkung und verfahren zu deren herstellung.

Country Status (10)

Country Link
EP (1) EP0498830B1 (de)
JP (1) JPH05501411A (de)
AT (1) ATE115550T1 (de)
AU (1) AU6637690A (de)
CA (1) CA2067569A1 (de)
DE (1) DE69015208T2 (de)
ES (1) ES2066232T3 (de)
IT (1) IT1238664B (de)
PT (1) PT95766A (de)
WO (1) WO1991006529A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) * 1992-04-09 1996-07-30 Rotta Research Lab Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico
WO1997044341A1 (en) * 1996-05-17 1997-11-27 Rotta Research Laboratorium S.P.A. Cyclic polyamides of glutamic acid and aspartic acid with anti-gastrin activity, a method for their preparation and their pharmaceutical use
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity

Also Published As

Publication number Publication date
AU6637690A (en) 1991-05-31
DE69015208T2 (de) 1995-05-04
EP0498830B1 (de) 1994-12-14
ATE115550T1 (de) 1994-12-15
CA2067569A1 (en) 1991-05-03
IT1238664B (it) 1993-09-01
EP0498830A1 (de) 1992-08-19
ES2066232T3 (es) 1995-03-01
IT8967937A1 (it) 1991-05-02
PT95766A (pt) 1991-09-13
WO1991006529A1 (en) 1991-05-16
IT8967937A0 (it) 1989-11-02
JPH05501411A (ja) 1993-03-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee