DE69007886D1 - Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung. - Google Patents

Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung.

Info

Publication number
DE69007886D1
DE69007886D1 DE90305377T DE69007886T DE69007886D1 DE 69007886 D1 DE69007886 D1 DE 69007886D1 DE 90305377 T DE90305377 T DE 90305377T DE 69007886 T DE69007886 T DE 69007886T DE 69007886 D1 DE69007886 D1 DE 69007886D1
Authority
DE
Germany
Prior art keywords
oestradiol
methods
topical use
containing agents
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90305377T
Other languages
English (en)
Other versions
DE69007886T2 (de
Inventor
Izhak Blank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL9106789A external-priority patent/IL91067A/en
Application filed by Individual filed Critical Individual
Publication of DE69007886D1 publication Critical patent/DE69007886D1/de
Application granted granted Critical
Publication of DE69007886T2 publication Critical patent/DE69007886T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69007886T 1989-07-21 1990-05-18 Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung. Expired - Fee Related DE69007886T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL9106789A IL91067A (en) 1989-07-21 1989-07-21 Sustained-release transdermal pharmaceutical compositions comprising estrogens
US46167690A 1990-01-08 1990-01-08

Publications (2)

Publication Number Publication Date
DE69007886D1 true DE69007886D1 (de) 1994-05-11
DE69007886T2 DE69007886T2 (de) 1994-11-17

Family

ID=26321962

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69007886T Expired - Fee Related DE69007886T2 (de) 1989-07-21 1990-05-18 Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung.

Country Status (4)

Country Link
US (1) US5128138A (de)
EP (1) EP0409383B1 (de)
JP (1) JPH0363223A (de)
DE (1) DE69007886T2 (de)

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US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5827245A (en) * 1992-07-16 1998-10-27 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising the active subtance 17-β-Estradiol (Anhydrous)
DE4422881A1 (de) * 1993-10-25 1995-04-27 Bayer Ag Kolloidal dispergierbare Wirkstoff-Formulierungen
FR2719220A1 (fr) * 1994-04-29 1995-11-03 Lafon Labor Nouvelle forme galénique pour l'administration transdermique.
JPH0827003A (ja) * 1994-07-22 1996-01-30 Sekisui Chem Co Ltd 経皮吸収製剤
FR2739030B1 (fr) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Utilisation d'un copolymere d'acetate de vinyle et de n-vinyl-2-pyrrolidone dans un systeme matriciel transdermique
DE19629468A1 (de) * 1996-07-11 1998-01-15 Schering Ag Transdermale therapeutische Systeme
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
FR2772270B1 (fr) * 1997-12-15 2002-06-07 Besins Iscovesco Lab Utilisation d'un oestrogene pour le traitement de la depression postnatale
DE19814730A1 (de) * 1998-04-02 1999-10-07 Basf Ag Verwendung von N-Vinyllacram oder N-Vinylamin haltigen Copolymeren als Matrix zur Herstellung von festen pharmazeutischen und kosmetischen Darreichungsformen
DE19834007C1 (de) * 1998-07-29 2000-02-24 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen und seine Verwendung
DE19911799A1 (de) * 1999-03-17 2000-09-28 Lohmann Therapie Syst Lts Sammelpackung zur Entnahme von befüllten Beuteln in vorgebener Reihenfolge
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
DE60143360D1 (de) 2000-08-03 2010-12-09 Antares Pharma Ipl Ag Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert
US6479076B2 (en) * 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions
DE10108387A1 (de) * 2001-02-21 2002-08-29 Basf Ag Kosmetisches oder pharmazeutisches Mittel
JP4422430B2 (ja) * 2003-05-14 2010-02-24 帝國製薬株式会社 エストロゲン及び／又はプロゲストゲン含有外用貼付剤
JP5619337B2 (ja) * 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
PL2219603T3 (pl) * 2007-11-02 2014-10-31 Acrux Dds Pty Ltd Układ transdermalnego dostarczania
US10080760B2 (en) 2009-10-27 2018-09-25 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

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US2776924A (en) * 1954-02-05 1957-01-08 Coty Inc Composition of matter containing polyvinylpyrrolidone and a fatty carrier
US2904810A (en) * 1957-08-20 1959-09-22 Owens Illinois Glass Co Ball-type applicator assembly
BE638231A (de) * 1962-03-16
US3214338A (en) * 1964-07-31 1965-10-26 Ehrlich Joseph Ronald Medicament releasing film-forming ointments and process of making
DE1467792A1 (de) * 1965-05-21 1968-12-12 Brunnengraeber & Co Gmbh Dr Ch Sprengmittel fuer pharmazeutische Presslinge
US3948262A (en) * 1969-04-01 1976-04-06 Alza Corporation Novel drug delivery device
FR2047874A6 (de) * 1969-06-10 1971-03-19 Nouvel Lucien
DE2012775C3 (de) * 1970-03-18 1973-10-04 V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed Salbenfohe und Verfahren zu ihrer Herstellung
DE2200778B2 (de) * 1971-01-13 1974-04-18 Sandoz Ag, Basel (Schweiz) Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen
DE2301664C3 (de) * 1973-01-13 1979-07-12 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel
US4091091A (en) * 1973-11-08 1978-05-23 Eli Lilly And Company Stabilized nitroglycerin tablets
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
SU806037A1 (ru) * 1978-04-06 1981-02-23 Всесоюзный Кардиологический Научныйцентр Amh Cccp Антиангинальное средство
US4210633A (en) * 1978-10-20 1980-07-01 Eli Lilly And Company Flurandrenolide film formulation
US4383993A (en) * 1980-05-30 1983-05-17 University Of Kentucky Research Foundation Nasal dosage forms containing natural female sex hormones
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4436738A (en) * 1982-03-15 1984-03-13 Mead Johnson & Company Stabilized estradiol cream composition
US4687481A (en) * 1984-10-01 1987-08-18 Biotek, Inc. Transdermal drug delivery system
AU563054B2 (en) * 1984-10-24 1987-06-25 Sekisui Kagaku Kogyo Kabushiki Kaisha Percutaneous tape of isdn
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
JP2931002B2 (ja) * 1988-02-26 1999-08-09 ライカー ラボラトリース インコーポレーテッド 皮膚透過エストラジオールデリバリーシステム
CA2000401C (en) * 1988-10-11 1996-05-28 Masato Azuma Percutaneous pharmaceutical preparation
US5154922A (en) * 1988-12-01 1992-10-13 Schering Corporation Compositions for transdermal delivery of estradiol

Also Published As

Publication number Publication date
EP0409383A2 (de) 1991-01-23
US5128138A (en) 1992-07-07
EP0409383A3 (en) 1991-04-03
EP0409383B1 (de) 1994-04-06
JPH0363223A (ja) 1991-03-19
DE69007886T2 (de) 1994-11-17

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Free format text: ERFINDER IST ANMELDER

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee