DE69004094D1 - Mehrphasige injizierbare emulsionen. - Google Patents

Mehrphasige injizierbare emulsionen.

Info

Publication number
DE69004094D1
DE69004094D1 DE90910772T DE69004094T DE69004094D1 DE 69004094 D1 DE69004094 D1 DE 69004094D1 DE 90910772 T DE90910772 T DE 90910772T DE 69004094 T DE69004094 T DE 69004094T DE 69004094 D1 DE69004094 D1 DE 69004094D1
Authority
DE
Germany
Prior art keywords
pct
formula
sec
phase
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90910772T
Other languages
English (en)
Other versions
DE69004094T2 (de
Inventor
Bernard Brancq
Gerard Trouve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Original Assignee
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA filed Critical Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Publication of DE69004094D1 publication Critical patent/DE69004094D1/de
Application granted granted Critical
Publication of DE69004094T2 publication Critical patent/DE69004094T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE90910772T 1989-07-03 1990-06-29 Mehrphasige injizierbare emulsionen. Expired - Fee Related DE69004094T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8908917A FR2649012B1 (fr) 1989-07-03 1989-07-03 Emulsions multiphasiques injectables
PCT/FR1990/000484 WO1991000106A1 (fr) 1989-07-03 1990-06-29 Emulsions multiphasiques injectables

Publications (2)

Publication Number Publication Date
DE69004094D1 true DE69004094D1 (de) 1993-11-25
DE69004094T2 DE69004094T2 (de) 1994-02-17

Family

ID=9383409

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90910772T Expired - Fee Related DE69004094T2 (de) 1989-07-03 1990-06-29 Mehrphasige injizierbare emulsionen.

Country Status (12)

Country Link
US (1) US5424067A (de)
EP (1) EP0480981B1 (de)
JP (1) JP2851422B2 (de)
AT (1) ATE96037T1 (de)
AU (1) AU643690B2 (de)
BR (1) BR9007501A (de)
DE (1) DE69004094T2 (de)
DK (1) DK0480981T3 (de)
ES (1) ES2061054T3 (de)
FR (1) FR2649012B1 (de)
NZ (1) NZ234336A (de)
WO (1) WO1991000106A1 (de)

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CA2083553A1 (en) * 1991-11-25 1993-05-26 Kuniharu Seki Immunogen composition
FR2702373B1 (fr) * 1993-03-08 1996-06-07 Rhone Merieux Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.
FR2717694B1 (fr) * 1994-03-22 1996-05-03 Seppic Sa Une composition comprenant un plasmide recombinant et ses utilisations comme vaccin et médicament.
US5690942A (en) † 1995-06-02 1997-11-25 American Home Products Corporation Adjuvants for viral vaccines
EP0781559B1 (de) * 1995-11-30 2007-02-07 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Öladjuvierter Impfstoff und Verfahren zu seiner Herstellung
GB9626865D0 (en) * 1996-12-24 1997-02-12 Cyanamid Websters Pty Limited Veterinary vaccines
AU776364B2 (en) * 1996-12-24 2004-09-09 Zoetis Services Llc Veterinary vaccines
US6524592B2 (en) 1997-10-17 2003-02-25 American Home Products Corporation Veterinary vaccines
WO1999020305A1 (en) 1997-10-17 1999-04-29 Fort Dodge Australia Pty. Limited Veterinary vaccines
AU769539B2 (en) * 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
FR2800280B1 (fr) * 1999-10-29 2003-09-19 Seppic Sa Nouvelle composition vaccinale et utilisation d'agents tensioactifs comme adjuvants d'immunite
JP2001131087A (ja) * 1999-11-05 2001-05-15 Chemo Sero Therapeut Res Inst オイルアジュバントワクチン
EP1246645A2 (de) * 1999-12-23 2002-10-09 Aphton Corporation Stabile immunogenische zusammensetzung zur gefrorene lagerung
FR2814956B1 (fr) * 2000-10-06 2003-01-24 Seppic Sa Nouvelle composition vaccinale, procede pour sa preparation, utilisation comme composition injectale en medecine humaine ou veterinaire et nouveau procede de conservation
DK1889630T3 (da) 2000-10-18 2012-03-05 Glaxosmithkline Biolog Sa Vacciner omfattende MAGE-antigen koblet til protein D-fragment
FR2823119B1 (fr) * 2001-04-05 2004-02-20 Seppic Sa Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant
FR2824279B1 (fr) * 2001-05-04 2004-05-28 Seppic Sa Emulsion e/h concentree
FR2824269B1 (fr) * 2001-09-03 2012-03-02 Seppic Sa Composition adjuvante constituee de 1% a 15% de tensioactifs a hlb global compris entre 5 et 8 et de 85% a 99% de corps gras
US20050158329A1 (en) * 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
GB0409940D0 (en) * 2004-05-04 2004-06-09 Glaxosmithkline Biolog Sa Vaccine
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
NO346529B1 (no) 2005-12-22 2022-09-26 Glaxosmithkline Biologicals Sa Bruk av et immunogenpreparat for småbarn, omfattende 22F sakkaridkonjugat
JP2009531387A (ja) 2006-03-30 2009-09-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
US20070292521A1 (en) * 2006-06-20 2007-12-20 Schwitzer Co., Ltd Oral Encapsulated Preparation for Aquatic Animals
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
CN101516396B (zh) 2006-09-26 2013-10-09 传染性疾病研究院 包含合成佐剂的疫苗组合物
CN101883583B (zh) 2007-06-26 2017-05-17 葛兰素史密丝克莱恩生物有限公司 含有肺炎链球菌荚膜多糖缀合物的疫苗
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
US8722064B2 (en) 2009-06-05 2014-05-13 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2353609A1 (de) 2010-02-04 2011-08-10 Sanofi Pasteur Immunisierungszusammensetzungen und -verfahren
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
EP3632463A1 (de) 2011-04-08 2020-04-08 Immune Design Corp. Immunogene zusammensetzungen und verfahren zur verwendung der zusammensetzungen zur induzierung humoraler und zellulärer immunreaktionen
EP2788477A2 (de) 2011-12-07 2014-10-15 Institut Pasteur Identifizierung des porcinen parecho-like virus und anwendungen
PL2811981T3 (pl) 2012-02-07 2019-09-30 Infectious Disease Research Institute Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania
NZ701881A (en) 2012-05-16 2016-10-28 Immune Design Corp Vaccines for hsv-2
EP3932422A1 (de) 2012-07-24 2022-01-05 Sanofi Pasteur Impfstoffzusammensetzungen zur vorbeugung von dengue-virus-infektionen
MX2015000446A (es) 2012-07-24 2015-03-12 Sanofi Pasteur Composiciones de vacuna para la prevencion contra la infeccion por el virus del dengue.
WO2014083194A1 (en) 2012-11-30 2014-06-05 Sanofi Pasteur Methods for inducing antibodies
EP3711768A1 (de) 2013-04-18 2020-09-23 Immune Design Corp. Gla-monotherapie zur verwendung in der krebsbehandlung
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
EP3915579A1 (de) 2013-12-31 2021-12-01 Infectious Disease Research Institute Impfstoffformulierungen mit einzelphiole
CN105960241A (zh) 2014-01-21 2016-09-21 免疫设计公司 用于治疗过敏性病症的组合物
US20150359880A1 (en) * 2014-06-16 2015-12-17 Biomune Company Dual adjuvant vaccine compositions, preparation and uses
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
MA40920A (fr) 2014-11-07 2017-09-12 Takeda Vaccines Inc Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
CN106267184B (zh) * 2016-03-03 2020-01-21 彭建彪 一种水包油包水型乳化剂及其用途和使用方法
WO2018231706A1 (en) 2017-06-11 2018-12-20 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
EP3703741A1 (de) 2017-11-03 2020-09-09 Takeda Vaccines, Inc. Zika-impfstoffe und immunogene zusammensetzungen und verfahren zu ihrer verwendung
MX2021014363A (es) 2019-05-25 2022-02-21 Infectious Disease Res Inst Composicion y metodo para secar por pulverizacion una emulsion de vacuna adyuvante.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1408437A (fr) * 1963-10-14 1965-08-13 Lummus Co Procédé de récupération du potentiel calorique d'un gaz liquéfié pendant la regazéification
GB1080994A (en) * 1963-10-25 1967-08-31 Nat Res Dev Injectable emulsions containing antigens
GB1408437A (en) * 1972-10-16 1975-10-01 C Vet Ltd Vaccines
US3983228A (en) * 1973-08-28 1976-09-28 Merck & Co., Inc. Water-in-oil adjuvant composition
US4069313A (en) * 1974-11-19 1978-01-17 Merck & Co., Inc. Water-in-oil adjuvant composition
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用ｗ／ｏ／ｗ型複合エマルジヨンの製造法
IL74289A (en) * 1985-02-10 1989-02-28 Israel State Vaccine system comprising a live-non-virulent vaccine and an adjuvant
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
AU614465B2 (en) * 1989-04-05 1991-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
JPH07501259A (ja) * 1990-06-01 1995-02-09 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド 自己乳化型ガラス

Also Published As

Publication number Publication date
FR2649012A1 (fr) 1991-01-04
EP0480981A1 (de) 1992-04-22
ATE96037T1 (de) 1993-11-15
DK0480981T3 (da) 1993-11-29
ES2061054T3 (es) 1994-12-01
DE69004094T2 (de) 1994-02-17
AU5961090A (en) 1991-01-17
EP0480981B1 (de) 1993-10-20
US5424067A (en) 1995-06-13
AU643690B2 (en) 1993-11-25
JP2851422B2 (ja) 1999-01-27
WO1991000106A1 (fr) 1991-01-10
JPH04507405A (ja) 1992-12-24
BR9007501A (pt) 1992-06-23
NZ234336A (en) 1992-07-28
FR2649012B1 (fr) 1991-10-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee