DE68924545D1 - Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln. - Google Patents

Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln.

Info

Publication number
DE68924545D1
DE68924545D1 DE68924545T DE68924545T DE68924545D1 DE 68924545 D1 DE68924545 D1 DE 68924545D1 DE 68924545 T DE68924545 T DE 68924545T DE 68924545 T DE68924545 T DE 68924545T DE 68924545 D1 DE68924545 D1 DE 68924545D1
Authority
DE
Germany
Prior art keywords
quinolizine
derivatives
manufacture
quinolizone
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68924545T
Other languages
English (en)
Other versions
DE68924545T2 (de
Inventor
Maurice W Gittos
Francis P Miller
Stephen M Sorensen
John R Fozard
Paul Moser
Michael G Palfreyman
Hsien C Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP88400416A external-priority patent/EP0329903A1/de
Priority claimed from EP88400417A external-priority patent/EP0329904A1/de
Priority claimed from EP88400418A external-priority patent/EP0329905A1/de
Priority claimed from EP88400415A external-priority patent/EP0329902A1/de
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE68924545D1 publication Critical patent/DE68924545D1/de
Application granted granted Critical
Publication of DE68924545T2 publication Critical patent/DE68924545T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE68924545T 1988-02-23 1989-01-11 Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln. Expired - Lifetime DE68924545T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP88400416A EP0329903A1 (de) 1988-02-23 1988-02-23 Verwendung von Chinolizinon- und Chinolizin-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Glaukom
EP88400417A EP0329904A1 (de) 1988-02-23 1988-02-23 Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Anxietas
EP88400418A EP0329905A1 (de) 1988-02-23 1988-02-23 Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln zur Erhöhung der Magenbeweglichkeit
EP88400415A EP0329902A1 (de) 1988-02-23 1988-02-23 Verwendung von Chinolizinon- und Chinolizin-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Psychose
US18563188A 1988-04-26 1988-04-26

Publications (2)

Publication Number Publication Date
DE68924545D1 true DE68924545D1 (de) 1995-11-23
DE68924545T2 DE68924545T2 (de) 1996-03-21

Family

ID=27513624

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68924545T Expired - Lifetime DE68924545T2 (de) 1988-02-23 1989-01-11 Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln.

Country Status (10)

Country Link
EP (1) EP0329932B1 (de)
JP (1) JPH02288880A (de)
KR (1) KR890013018A (de)
AT (1) ATE129153T1 (de)
AU (1) AU624115B2 (de)
DE (1) DE68924545T2 (de)
DK (1) DK175643B1 (de)
ES (1) ES2080727T3 (de)
GR (1) GR3018299T3 (de)
IE (1) IE72504B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69004924T2 (de) * 1989-04-21 1994-05-19 Sandoz Ag Therapeutische verwendung von 5-ht3-rezeptor-antagonisten.
EP0492020A1 (de) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Verwendung von bestimmten Estern von Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-on und verwandter Verbindungen zur Behandlung von kognitiven Erkrankungen
US5508287A (en) * 1992-02-24 1996-04-16 Merrell Pharmaceuticals Inc. 2,6-methano-2H-quinolizin derivative as 5-HT3 -receptor antagonist
JPH07504192A (ja) * 1992-02-24 1995-05-11 メレルダウファーマス−ティカルズ　インコーポレイテッド ５−ｈｔ３受容体拮抗剤としての２，６‐メタノ‐２ｈ‐キノリジン誘導体
MX2009010174A (es) * 2007-03-23 2009-10-12 Abbott Lab Derivados de aza-adamantano ester y carbamato y metodos de uso de los mismos.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
CH664567A5 (de) * 1983-08-26 1988-03-15 Sandoz Ag Aromatische carbonsaeure- und sulfonsaeureester oder -amide.
DE3445377A1 (de) * 1983-12-23 1985-07-04 Sandoz-Patent-GmbH, 7850 Lörrach Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
EP0191562B1 (de) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolonderivate
EP0201165B1 (de) * 1985-03-14 1994-07-20 Beecham Group Plc Arzneimittel zur Behandlung von Emesis
GB8525913D0 (en) * 1985-10-21 1985-11-27 Beecham Group Plc Compounds
GB8511988D0 (en) * 1985-05-11 1985-06-19 Beecham Group Plc Compounds
GB8520616D0 (en) * 1985-08-16 1985-09-25 Beecham Group Plc Compounds
GB8523211D0 (en) * 1985-09-19 1985-10-23 Beecham Group Plc Compounds
EP0220011A3 (de) * 1985-10-12 1990-01-03 Beecham Group Plc Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
EP0330788A1 (de) * 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Herz-Arrhythmie

Also Published As

Publication number Publication date
EP0329932B1 (de) 1995-10-18
IE890564L (en) 1989-08-23
DK80989D0 (da) 1989-02-22
IE72504B1 (en) 1997-04-23
ES2080727T3 (es) 1996-02-16
DK80989A (da) 1989-08-24
AU3021489A (en) 1989-08-24
EP0329932A2 (de) 1989-08-30
ATE129153T1 (de) 1995-11-15
AU624115B2 (en) 1992-06-04
GR3018299T3 (en) 1996-03-31
EP0329932A3 (de) 1992-08-05
DE68924545T2 (de) 1996-03-21
JPH02288880A (ja) 1990-11-28
KR890013018A (ko) 1989-09-20
DK175643B1 (da) 2005-01-03

Similar Documents

Publication Publication Date Title
DE69825292D1 (de) Verwendung von inosine zur herstellung eines medikamentes zur stimulierung des axonwachstums von zns-neuronen
HUT49113A (en) Process for producing 2-/2-hydroxy-3-phenoxy-propyl-amino/-ethyl-phenoxy-methyl-amido derivatives and pharmaceutical compositions containing them as active components
ATE194920T1 (de) Pro-prodrugs, ihre herstellung und anwendung
NO172344C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte flavonoidforbindelser og salter
DK217588D0 (da) 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler
NO910868D0 (no) Antiglaukompreparater inneholdende 3-arylkarbonyl-1-aminoalkyl-1h-indol og fremgangsmaate for fremstilling derav.
GR3001559T3 (en) Polyoxygenated labdane derivatives, process for their preparation and their use as medicaments
DE68924545T2 (de) Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln.
DE68909254D1 (de) Heparinbindende Gehirnmitogene.
IT8921893A0 (it) Procedimento per la produzione di impiallacciatura artificiale ad imitazione della radica, mediante bruciature.
DE3863191D1 (de) Substituierte aminderivate, ihre herstellung und verwendung.
DE68918479D1 (de) Menschlicher Hitzeschock-Faktor.
DE69323299T2 (de) Treibmittelzusammensetzung, herstellung von schaumstoff mittels dieser zusammensetzung und daraus hergestellte schaumstoffe
DE3873696T2 (de) Derivate des cysteins, verfahren zur herstellung und verwendung davon.
ATE99687T1 (de) Strobilurinderivate, ihre herstellung und verwendung.
KR900009637A (ko) 1,7'-[이미다조-[1,2-a]피리딘]5'-(6'H)온 유도체 및 이의 제조방법
CS39189A2 (en) Method of tetrahydropyridine derivatives production
ATE84543T1 (de) Herstellung von hoch-gereingtem menschlichen faktor ix sowie anderem plasmaproteinkonzentrat und dessen therapeutische verwendung.
DE58901297D1 (de) Noremopamil, seine herstellung und verwendung.
NO170331C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive acyleringsprodukter av bis(2-imidazolin-2-ylhydrazoner)av 9,10-antracen- dikarboksaldehyd
ES2013877A6 (es) Nuevo procedimiento para producir derivados de imidazopiridina.
DE68906028D1 (de) Verwendung von acetyl-d-carnitin zur therapeutischen behandlung von glaukom.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERRELL PHARMACEUTICALS INC. (N.D.GES.D. STAATES D

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR