DE68922336T2 - Sonden für Papilloma-Virus (HPV49, HPV50, HPV54, HPV55), zu diesem Papilloma-Virus genetisch und immunologisch verwandte Produkte und in vitro Methoden zur Diagnose von Papilloma-Virusinfektionen und Herstellung von Antikörpern gegen diese Papilloma-Viren. - Google Patents
Sonden für Papilloma-Virus (HPV49, HPV50, HPV54, HPV55), zu diesem Papilloma-Virus genetisch und immunologisch verwandte Produkte und in vitro Methoden zur Diagnose von Papilloma-Virusinfektionen und Herstellung von Antikörpern gegen diese Papilloma-Viren.Info
- Publication number
- DE68922336T2 DE68922336T2 DE68922336T DE68922336T DE68922336T2 DE 68922336 T2 DE68922336 T2 DE 68922336T2 DE 68922336 T DE68922336 T DE 68922336T DE 68922336 T DE68922336 T DE 68922336T DE 68922336 T2 DE68922336 T2 DE 68922336T2
- Authority
- DE
- Germany
- Prior art keywords
- dna
- papillomavirus
- deposited
- under
- hpv49
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241001631646 Papillomaviridae Species 0.000 title claims abstract description 82
- 239000000523 sample Substances 0.000 title claims abstract description 54
- 238000000338 in vitro Methods 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims description 29
- 238000003745 diagnosis Methods 0.000 title claims description 21
- 208000009608 Papillomavirus Infections Diseases 0.000 title description 4
- 238000004519 manufacturing process Methods 0.000 title description 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 31
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 208000000260 Warts Diseases 0.000 claims abstract description 19
- 210000004392 genitalia Anatomy 0.000 claims abstract description 14
- 206010059313 Anogenital warts Diseases 0.000 claims abstract description 12
- 238000001514 detection method Methods 0.000 claims abstract description 11
- 230000009826 neoplastic cell growth Effects 0.000 claims abstract description 11
- 208000003154 papilloma Diseases 0.000 claims abstract description 7
- 238000003748 differential diagnosis Methods 0.000 claims abstract description 6
- 108020004414 DNA Proteins 0.000 claims description 160
- 238000009396 hybridization Methods 0.000 claims description 40
- 239000012634 fragment Substances 0.000 claims description 35
- 201000010153 skin papilloma Diseases 0.000 claims description 29
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
- 201000004306 epidermodysplasia verruciformis Diseases 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 11
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 8
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 8
- 108020005202 Viral DNA Proteins 0.000 claims description 8
- 201000010881 cervical cancer Diseases 0.000 claims description 8
- 208000020082 intraepithelial neoplasia Diseases 0.000 claims description 7
- 201000000849 skin cancer Diseases 0.000 claims description 6
- 239000012472 biological sample Substances 0.000 claims description 4
- 238000011835 investigation Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims 1
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 abstract description 9
- 241000934136 Verruca Species 0.000 abstract 2
- 210000004291 uterus Anatomy 0.000 abstract 2
- 241000701806 Human papillomavirus Species 0.000 description 92
- 239000000203 mixture Substances 0.000 description 24
- 230000002285 radioactive effect Effects 0.000 description 22
- 238000003776 cleavage reaction Methods 0.000 description 21
- 230000007017 scission Effects 0.000 description 21
- 241000700605 Viruses Species 0.000 description 14
- 239000013612 plasmid Substances 0.000 description 14
- 230000003902 lesion Effects 0.000 description 13
- 108020004511 Recombinant DNA Proteins 0.000 description 11
- 108091008146 restriction endonucleases Proteins 0.000 description 11
- 108020003215 DNA Probes Proteins 0.000 description 10
- 239000003298 DNA probe Substances 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 241001515965 unidentified phage Species 0.000 description 10
- 108091029795 Intergenic region Proteins 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 230000035945 sensitivity Effects 0.000 description 9
- 201000009030 Carcinoma Diseases 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 6
- 230000005855 radiation Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108091027305 Heteroduplex Proteins 0.000 description 5
- 206010020649 Hyperkeratosis Diseases 0.000 description 5
- 208000001126 Keratosis Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 108010054576 Deoxyribonuclease EcoRI Proteins 0.000 description 4
- 206010061978 Genital lesion Diseases 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 238000012512 characterization method Methods 0.000 description 4
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 208000010932 epithelial neoplasm Diseases 0.000 description 4
- 230000008696 hypoxemic pulmonary vasoconstriction Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 238000010369 molecular cloning Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000014886 Buschke-Lowenstein tumour Diseases 0.000 description 3
- 206010048768 Dermatosis Diseases 0.000 description 3
- 108010042407 Endonucleases Proteins 0.000 description 3
- 102000004533 Endonucleases Human genes 0.000 description 3
- 241000341655 Human papillomavirus type 16 Species 0.000 description 3
- 101150027802 L2 gene Proteins 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 230000009089 cytolysis Effects 0.000 description 3
- 238000010218 electron microscopic analysis Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 101100478056 Dictyostelium discoideum cotE gene Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241001646716 Escherichia coli K-12 Species 0.000 description 2
- 241000701959 Escherichia virus Lambda Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010023347 Keratoacanthoma Diseases 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 206010008263 Cervical dysplasia Diseases 0.000 description 1
- 108010005054 Deoxyribonuclease BamHI Proteins 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 208000002471 Penile Neoplasms Diseases 0.000 description 1
- 101000626624 Streptomyces achromogenes Type II restriction enzyme SacI Proteins 0.000 description 1
- 108091027544 Subgenomic mRNA Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 206010006060 bowenoid papulosis Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000007951 cervical intraepithelial neoplasia Diseases 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000002380 cytological effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000024312 invasive carcinoma Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000011252 penile benign neoplasm Diseases 0.000 description 1
- 235000012830 plain croissants Nutrition 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8806486A FR2631341B1 (fr) | 1988-05-13 | 1988-05-13 | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55 et produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55 et procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
FR888808324A FR2632956B2 (fr) | 1988-05-13 | 1988-06-21 | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68922336D1 DE68922336D1 (de) | 1995-06-01 |
DE68922336T2 true DE68922336T2 (de) | 1995-11-09 |
Family
ID=26226663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68922336T Expired - Lifetime DE68922336T2 (de) | 1988-05-13 | 1989-05-12 | Sonden für Papilloma-Virus (HPV49, HPV50, HPV54, HPV55), zu diesem Papilloma-Virus genetisch und immunologisch verwandte Produkte und in vitro Methoden zur Diagnose von Papilloma-Virusinfektionen und Herstellung von Antikörpern gegen diese Papilloma-Viren. |
Country Status (8)
Country | Link |
---|---|
US (5) | US5342930A (ja) |
EP (1) | EP0342128B1 (ja) |
JP (2) | JPH0235086A (ja) |
AT (1) | ATE121749T1 (ja) |
DE (1) | DE68922336T2 (ja) |
ES (1) | ES2072308T3 (ja) |
FR (1) | FR2632956B2 (ja) |
HK (1) | HK185095A (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5952015A (ja) * | 1982-09-14 | 1984-03-26 | Nippon Soiru Kogyo Kk | グラウト注入工法およびその装置 |
FR2632956B2 (fr) * | 1988-05-13 | 1991-07-12 | Pasteur Institut | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
FR2661921B1 (fr) * | 1990-05-11 | 1992-08-07 | Pasteur Institut | Sonde a papillomavirus (hpv66), notamment pour le diagnostic in vitro d'infections a papillomavirus, pouvant s'accompagner de neoplasies genitales, et produits genetiquement et immunologiquement lies a ce papillomavirus. |
GB9113809D0 (en) | 1991-06-26 | 1991-08-14 | Cancer Res Campaign Tech | Papillomavirus l2 protein |
ATE236271T1 (de) | 1993-04-30 | 2003-04-15 | Wellstat Biologics Corp | Verwendung der ndv zur herstellung eines medikaments zur krebsbehandlung |
US6365787B1 (en) * | 1994-09-30 | 2002-04-02 | The Johns Hopkins University | Compounds for the suppression of HIV TAT transactivation |
WO2000024940A1 (en) * | 1998-10-28 | 2000-05-04 | Vysis, Inc. | Cellular arrays and methods of detecting and using genetic disorder markers |
WO2000061804A1 (en) * | 1999-04-14 | 2000-10-19 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
DE10009143B4 (de) * | 2000-02-26 | 2012-04-26 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Nachweis von Humanen Papillomviren |
US20030059806A1 (en) * | 2001-01-05 | 2003-03-27 | Science & Technology Corporation @ Unm | Probes for the detection of human papillomavirus |
AU2003213065A1 (en) * | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Novel insect cell line |
CA2491034A1 (en) * | 2002-06-26 | 2004-01-08 | The Penn State Research Foundation | Methods and materials for treating human papillomavirus infections |
WO2005030041A2 (en) | 2003-09-25 | 2005-04-07 | Third Wave Technologies, Inc. | Detection of hpv |
ATE476528T1 (de) | 2004-12-08 | 2010-08-15 | Gen Probe Inc | Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus |
US20070031826A1 (en) * | 2005-08-05 | 2007-02-08 | My Gene | Diagnostic kit for determining the genotype of a human papilloma virus and method of using thereof |
US7972776B2 (en) * | 2005-11-15 | 2011-07-05 | Oncohealth Corporation | Protein chips for HPV detection |
US8080643B2 (en) * | 2006-09-05 | 2011-12-20 | Third Wave Technologies, Inc. | HPV primers |
US8278056B2 (en) | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
US8916342B2 (en) | 2006-11-13 | 2014-12-23 | Oncohealth Corp. | Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers |
US8257916B2 (en) * | 2007-10-31 | 2012-09-04 | Sysmex Corporation | Method for detecting integrated HPV DNA |
JP5306683B2 (ja) * | 2007-10-31 | 2013-10-02 | シスメックス株式会社 | 組み込み型ヒトパピローマウイルスの有無の判定方法 |
EP2521914A4 (en) | 2010-01-08 | 2013-07-10 | Oncohealth Corp | CELL-BASED HPV IMMUNOTESTS HAVE A HIGH PERFORMANCE FOR DIAGNOSIS AND SCANNING OF HPV ASSOCIATED CANCER |
AU2011258501B2 (en) | 2010-05-25 | 2016-07-07 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2524487B1 (fr) * | 1982-04-05 | 1985-11-22 | Pasteur Institut | Fragments d'adn codant pour des polypeptides contenant au moins un determinant antigenique des papillomavirus, notamment du type hpv 1a et polypeptides correspondants |
US4748109A (en) * | 1983-07-01 | 1988-05-31 | Baird Phillip J | Assay method and reagent to determine antibodies to papillomavirus virions |
CA1276575C (fr) * | 1984-11-30 | 1990-11-20 | Sylvie Beaudenon | Sondes a papillomavirus et procede de diagnostic in vitro d'infections a papillomavirus |
FR2593828B2 (fr) * | 1986-01-31 | 1990-05-04 | Pasteur Institut | Sonde a papillomavirus et procede de diagnostic in-vitro d'infections a papillomavirus |
JP2648303B2 (ja) * | 1985-04-04 | 1997-08-27 | ジョージタウン・ユニバーシティ | 型特異的乳頭腫ウイルスdna配列およびペプチド |
FR2586428B1 (fr) * | 1985-08-26 | 1988-11-25 | Pasteur Institut | Polypeptides et anticorps, caracteristiques du papillomavirus et leurs applications au diagnostic in vitro, a la prevention et/ou la lutte contre des infections a papillomavirus |
KR930007580B1 (ko) * | 1986-03-21 | 1993-08-13 | 엥스띠뛰 빠스뙤르 | 유두종 비루스 게놈으로부터 유도된 결정 dna 서열, 그의 시험관내 진단 목적용 용도 및 항원 조성물의 제조 방법 |
US4849332A (en) * | 1987-05-26 | 1989-07-18 | Life Technologies, Inc. | Human papillomavirus 35 nucleic acid hybridization probes and methods for employing the same |
US4849334A (en) * | 1987-06-09 | 1989-07-18 | Life Technologies, Inc. | Human papillomavirus 43 nucleic acid hybridization probes and methods for employing the same |
US4849331A (en) * | 1987-06-09 | 1989-07-18 | Life Technologies, Inc. | Human papillomavirus 44 nucleic acid hybridization probes and methods for employing the same |
US4908306A (en) * | 1987-06-12 | 1990-03-13 | Life Technologies, Inc. | Human papillomavirus 56 nucleic acid hybridization probes and methods for employing the same |
WO1989009940A1 (en) * | 1988-04-04 | 1989-10-19 | Oncor, Inc. | Human papilloma virus typing method and nucleic acid probes used therein |
FR2632956B2 (fr) * | 1988-05-13 | 1991-07-12 | Pasteur Institut | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
US5182377A (en) * | 1988-09-09 | 1993-01-26 | Hoffmann-La Roche Inc. | Probes for detection of human papillomavirus |
CA2052413C (en) * | 1990-09-28 | 2004-07-13 | Jeffrey L. Joseph | Nucleotides sequences useful as type-specific probes, pcr primers and lcr probes for the amplifications and detection of human papilloma virus, and related kits and methods |
IT1244462B (it) * | 1990-12-06 | 1994-07-15 | Sclavo Spa | Oligonucleotidi sintetici utili per la diagnosi di infezione da tipi diversi di virus del gruppo papilloma e loro utilizzazione |
-
1988
- 1988-06-21 FR FR888808324A patent/FR2632956B2/fr not_active Expired - Lifetime
-
1989
- 1989-05-12 DE DE68922336T patent/DE68922336T2/de not_active Expired - Lifetime
- 1989-05-12 ES ES89401342T patent/ES2072308T3/es not_active Expired - Lifetime
- 1989-05-12 EP EP89401342A patent/EP0342128B1/fr not_active Expired - Lifetime
- 1989-05-12 AT AT89401342T patent/ATE121749T1/de not_active IP Right Cessation
- 1989-05-15 JP JP1118845A patent/JPH0235086A/ja active Pending
-
1992
- 1992-09-25 US US07/951,118 patent/US5342930A/en not_active Expired - Lifetime
-
1994
- 1994-05-10 US US08/240,497 patent/US5534439A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/466,291 patent/US5591574A/en not_active Expired - Lifetime
- 1995-12-07 HK HK185095A patent/HK185095A/xx not_active IP Right Cessation
-
1996
- 1996-04-02 US US08/626,347 patent/US5824466A/en not_active Expired - Lifetime
-
1998
- 1998-04-27 JP JP11634998A patent/JP3207389B2/ja not_active Expired - Lifetime
- 1998-08-20 US US09/136,425 patent/US5968522A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5824466A (en) | 1998-10-20 |
ES2072308T3 (es) | 1995-07-16 |
US5342930A (en) | 1994-08-30 |
JPH1128088A (ja) | 1999-02-02 |
US5591574A (en) | 1997-01-07 |
HK185095A (en) | 1995-12-15 |
JP3207389B2 (ja) | 2001-09-10 |
DE68922336D1 (de) | 1995-06-01 |
ATE121749T1 (de) | 1995-05-15 |
FR2632956A2 (fr) | 1989-12-22 |
US5968522A (en) | 1999-10-19 |
US5534439A (en) | 1996-07-09 |
EP0342128A1 (fr) | 1989-11-15 |
FR2632956B2 (fr) | 1991-07-12 |
EP0342128B1 (fr) | 1995-04-26 |
JPH0235086A (ja) | 1990-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE68922336T2 (de) | Sonden für Papilloma-Virus (HPV49, HPV50, HPV54, HPV55), zu diesem Papilloma-Virus genetisch und immunologisch verwandte Produkte und in vitro Methoden zur Diagnose von Papilloma-Virusinfektionen und Herstellung von Antikörpern gegen diese Papilloma-Viren. | |
DE3853678T2 (de) | Verfahren zum nachweis des karzinogenen menschlichen papillomavirus. | |
DE69104380T2 (de) | Vom genom des papillomavirus-hpv-39 abgeleitete dns-sequenzen, deren anwendung in der in vitro-diagnose und zur herstellung einer immunogenenzusammensetzung. | |
DE68918237T2 (de) | DNS-Sequenzen des menschlichen Papillomavirus Typ 52 und Verfahren zu ihrer Verwendung. | |
DE3786357T2 (de) | Sonden für Papilloma-Virus und Verfahren zur Diagnose der Papilloma-Virusinfektionen. | |
DE69226775T2 (de) | Dns-sequenzen von hpv42 papillomavirus :verwendungsmöglichkeit für diagnose | |
DE4415743C2 (de) | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen | |
DE10009143B4 (de) | Nachweis von Humanen Papillomviren | |
DE19526386C1 (de) | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen | |
DE3886450T2 (de) | Aus Nukleinsäuren von menschlichen Papillomaviren bestehende Hybridisierungsproben und Methoden für deren Anwendung. | |
EP2062983A2 (de) | Primer und Sonden zum Nachweis genitaler HPV-Genotypen | |
DE19648962C1 (de) | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen | |
DE19735118C1 (de) | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen | |
EP0972047A2 (de) | Papillomviren-hauptcapsid-proteins und deren verwendung in diagnose, therapie und vakzinierung | |
EP0458668A1 (fr) | Sonde à papillomavirus (HPV66), notamment pour le diagnostic in vitro d'infections à papillomavirus, pouvant s'accompagner de néoplasies génitales, et produits génétiquement et immunologiquement liés à ce papillomavirus | |
DE4332596A1 (de) | Monoklonale Antikörper | |
DE19840263C1 (de) | Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen | |
FR2656627A1 (fr) | Sonde a papillomavirus (hvpv63), notamment pour le diagnostic in vitro d'infections a papillomavirus, pouvant s'accompagner de neoplasies genitales, et produits genetiquement et immunologiquement lies a ce papillomavirus. | |
FR2631341A1 (fr) | Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55 et produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55 et procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE |