DE68917517D1 - Azacyclische Carbonsäurederivate,ihre Herstellung und Verwendung. - Google Patents

Azacyclische Carbonsäurederivate,ihre Herstellung und Verwendung.

Info

Publication number
DE68917517D1
DE68917517D1 DE68917517T DE68917517T DE68917517D1 DE 68917517 D1 DE68917517 D1 DE 68917517D1 DE 68917517 T DE68917517 T DE 68917517T DE 68917517 T DE68917517 T DE 68917517T DE 68917517 D1 DE68917517 D1 DE 68917517D1
Authority
DE
Germany
Prior art keywords
preparation
carboxylic acid
acid derivatives
azacyclic carboxylic
azacyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68917517T
Other languages
English (en)
Other versions
DE68917517T2 (de
Inventor
Lars Jacob Stray Knutsen
Knud Erik Andersen
Anker Steen Jorgensen
Ursula Sonnewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of DE68917517D1 publication Critical patent/DE68917517D1/de
Application granted granted Critical
Publication of DE68917517T2 publication Critical patent/DE68917517T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
DE68917517T 1988-05-18 1989-05-17 Azacyclische Carbonsäurederivate,ihre Herstellung und Verwendung. Expired - Fee Related DE68917517T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK270488A DK270488D0 (da) 1988-05-18 1988-05-18 Hidtil ukendte o-substituerede ketoximer

Publications (2)

Publication Number Publication Date
DE68917517D1 true DE68917517D1 (de) 1994-09-22
DE68917517T2 DE68917517T2 (de) 1994-12-15

Family

ID=8114842

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68917517T Expired - Fee Related DE68917517T2 (de) 1988-05-18 1989-05-17 Azacyclische Carbonsäurederivate,ihre Herstellung und Verwendung.

Country Status (18)

Country Link
US (1) US5039685A (de)
EP (1) EP0342635B1 (de)
JP (1) JP2824661B2 (de)
KR (1) KR900018058A (de)
AT (1) ATE110064T1 (de)
AU (1) AU622178B2 (de)
CA (1) CA1337123C (de)
DE (1) DE68917517T2 (de)
DK (1) DK270488D0 (de)
ES (1) ES2058383T3 (de)
FI (1) FI93955C (de)
IE (1) IE66016B1 (de)
IL (1) IL90313A0 (de)
NO (1) NO177262C (de)
NZ (1) NZ229136A (de)
PH (1) PH26373A (de)
PT (1) PT90607B (de)
ZA (1) ZA893733B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
JP2765876B2 (ja) * 1988-10-24 1998-06-18 科研製薬株式会社 ピリジルケトオキシムエーテル誘導体
DK93791D0 (da) * 1991-05-17 1991-05-17 Novo Nordisk As Nye heterocykliske carboxylsyrer
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
TW266206B (de) * 1993-04-28 1995-12-21 Takeda Pharm Industry Co Ltd
DK74493D0 (da) * 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
DK74393D0 (da) * 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
CA2202578A1 (en) * 1996-04-15 1997-10-15 Mitsuru Shiraishi Hydroxypyridine derivatives, their production and use
AU3104097A (en) * 1996-06-27 1998-01-14 Ciaran Regan Use of nipecotic acid or guvacine derivatives for the manufacture of a medicament for the treatment of postischemic neurodegenerative disorders
EP1142584A4 (de) * 1999-01-12 2003-04-16 Takeda Chemical Industries Ltd Zusammensetzungen zur behandlung häufigen harnlassens sowie harninkontinenz

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235931A (en) * 1967-04-05 1980-11-25 Duphar International Research B.V. Compounds having pharmacological properties
FR2162312B1 (de) * 1971-12-10 1975-02-07 Buzas Andre
US4207319A (en) * 1973-10-19 1980-06-10 Albert Rolland S.A. Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof
FR2248033B1 (de) 1973-10-19 1977-03-11 Cerpha
US4148911A (en) * 1977-07-08 1979-04-10 Societe Anonyme Dite Albert Rolland S.A. Method of treating respiratory disorders
DE2851387A1 (de) * 1977-11-28 1979-06-07 Degussa Aminoaethyloxime mit mindestens einem thienylrest und verfahren zu deren herstellung
AU532700B2 (en) * 1979-04-02 1983-10-13 Sumitomo Chemical Company, Limited Diphenylalkanoether
JPS5626863A (en) * 1979-08-13 1981-03-16 Sumitomo Chem Co Ltd Novel diphenylalkanone oxime derivative
US4722930A (en) * 1980-03-01 1988-02-02 John Wyeth And Brother Limited 3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
FI864246A7 (fi) * 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
DK165692C (da) * 1986-01-07 1993-11-08 Novo Nordisk As Phenylbutenderivater, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat indeholdende disse, samt anvendelse af disse til fremstilling af et medikament nyttigt til inhibering af gaba-optagelse i mennesker

Also Published As

Publication number Publication date
ES2058383T3 (es) 1994-11-01
IL90313A0 (en) 1989-12-15
DK270488D0 (da) 1988-05-18
JPH0217158A (ja) 1990-01-22
US5039685A (en) 1991-08-13
IE891533L (en) 1989-11-18
PT90607A (pt) 1989-11-30
FI93955C (fi) 1995-06-26
NO891970D0 (no) 1989-05-16
NO891970L (no) 1989-11-20
NZ229136A (en) 1992-01-29
PH26373A (en) 1992-06-01
KR900018058A (ko) 1990-12-20
AU622178B2 (en) 1992-04-02
AU3484589A (en) 1989-11-23
JP2824661B2 (ja) 1998-11-11
EP0342635B1 (de) 1994-08-17
NO177262C (no) 1995-08-16
FI892388A0 (fi) 1989-05-18
FI892388A7 (fi) 1989-11-19
ATE110064T1 (de) 1994-09-15
EP0342635A1 (de) 1989-11-23
ZA893733B (en) 1990-02-28
DE68917517T2 (de) 1994-12-15
PT90607B (pt) 1995-03-01
NO177262B (no) 1995-05-08
FI93955B (fi) 1995-03-15
CA1337123C (en) 1995-09-26
IE66016B1 (en) 1995-11-29

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee