DE68916177T2 - Chemisch modifizierte hydrophile Prepolymere und Polymere. - Google Patents

Chemisch modifizierte hydrophile Prepolymere und Polymere.

Info

Publication number
DE68916177T2
DE68916177T2 DE68916177T DE68916177T DE68916177T2 DE 68916177 T2 DE68916177 T2 DE 68916177T2 DE 68916177 T DE68916177 T DE 68916177T DE 68916177 T DE68916177 T DE 68916177T DE 68916177 T2 DE68916177 T2 DE 68916177T2
Authority
DE
Germany
Prior art keywords
polymers
chemically modified
modified hydrophilic
hydrophilic prepolymers
prepolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916177T
Other languages
English (en)
Other versions
DE68916177D1 (de
Inventor
James Anthony Braatz
Aaron Herman Heifetz
Richard Alan Wolfe
Narender Pal Luthra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co Conn
WR Grace and Co
Original Assignee
WR Grace and Co Conn
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co Conn, WR Grace and Co filed Critical WR Grace and Co Conn
Application granted granted Critical
Publication of DE68916177D1 publication Critical patent/DE68916177D1/de
Publication of DE68916177T2 publication Critical patent/DE68916177T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/2805—Compounds having only one group containing active hydrogen
    • C08G18/2815—Monohydroxy compounds
    • C08G18/283—Compounds containing ether groups, e.g. oxyalkylated monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S521/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S521/905—Hydrophilic or hydrophobic cellular product
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S528/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S528/904—Isocyanate polymer having stated hydrophilic or hydrophobic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyethers (AREA)
DE68916177T 1988-11-02 1989-10-27 Chemisch modifizierte hydrophile Prepolymere und Polymere. Expired - Fee Related DE68916177T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/266,445 US4940737A (en) 1988-11-02 1988-11-02 Chemically modified hydrophilic prepolymers and polymers

Publications (2)

Publication Number Publication Date
DE68916177D1 DE68916177D1 (de) 1994-07-21
DE68916177T2 true DE68916177T2 (de) 1994-09-22

Family

ID=23014619

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916177T Expired - Fee Related DE68916177T2 (de) 1988-11-02 1989-10-27 Chemisch modifizierte hydrophile Prepolymere und Polymere.

Country Status (6)

Country Link
US (1) US4940737A (de)
EP (1) EP0367362B1 (de)
JP (1) JPH02209915A (de)
AU (1) AU620930B2 (de)
DE (1) DE68916177T2 (de)
NZ (1) NZ231230A (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US5135866A (en) * 1989-03-03 1992-08-04 W. R. Grace & Co.-Conn. Very low protein nutrient medium for cell culture
US5118779A (en) * 1989-10-10 1992-06-02 Polymedica Industries, Inc. Hydrophilic polyurethane elastomers
JPH0480224A (ja) * 1990-07-23 1992-03-13 Dai Ichi Kogyo Seiyaku Co Ltd 水硬性ポリウレタンプレポリマー組成物
JP3158387B2 (ja) * 1991-02-22 2001-04-23 大日本インキ化学工業株式会社 イソシアヌレート環含有ポリウレタンポリ尿素架橋粒子およびその製造方法
US5403750A (en) * 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
US5496911A (en) * 1993-10-04 1996-03-05 Ecp Enichem Polimeri Netherlands, B.V. Process for the production of polyurea based articles
US5650450A (en) * 1996-01-25 1997-07-22 Foamex L.P. Hydrophilic urethane foam
US5877254A (en) * 1996-07-22 1999-03-02 Film Specialties, Inc. Scratch-resistant anti-fog coating composition incorporating isocyanate-reactive surfactants
DE60137489D1 (de) * 2000-02-03 2009-03-12 Tissuemed Ltd Gerät zum verschliessen einer chirurgischen punktionswunde
JP4573391B2 (ja) * 2000-03-17 2010-11-04 関西ペイント株式会社 含水ゲル、その製造法及びその用途
AU7595701A (en) 2000-07-17 2002-01-30 Harvard College Surfaces that resist the adsorption of biological species
DE60108258T2 (de) * 2000-10-23 2006-03-16 Tissuemed Ltd. Selbstklebende, hydratierbare matrix für therapeutische anwendungen
EP1370249A4 (de) * 2001-02-26 2006-05-03 Univ Duke Neue dendriticpolymere und ihre biomedizinischen anwendungen
US20040068078A1 (en) * 2001-12-12 2004-04-08 Milbocker Michael T. In situ polymerizing medical compositions
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US6939453B2 (en) * 2002-08-14 2005-09-06 Large Scale Proteomics Corporation Electrophoresis process using ionic liquids
GB0220313D0 (en) * 2002-08-31 2002-10-09 Graham Neil Novel thermoplastic hydrogel polmer compositions and methods of producing said compositions
CA2521661A1 (en) * 2003-04-04 2004-10-14 Tissuemed Limited Tissue-adhesive formulations
US7282584B2 (en) 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
DE602004011660T2 (de) 2004-06-16 2009-01-29 Straumann Holding Ag Abdeckmembran
US8133504B2 (en) * 2004-08-03 2012-03-13 Tissuemed Limited Tissue-adhesive materials
EP1813631B1 (de) * 2004-09-30 2011-03-23 Asahi Glass Company, Limited Verfahren zur herstellung von urethanharz und haftklebstoff
KR101181218B1 (ko) 2004-12-24 2012-09-07 에스케이케미칼주식회사 친수성 폴리우레탄 발포체 조성물과 이의 제조방법
US8029774B2 (en) 2005-07-01 2011-10-04 University Of Pittsburgh Wound healing polymeric networks
WO2007035527A2 (en) * 2005-09-15 2007-03-29 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
EP1996243B1 (de) 2006-01-11 2014-04-23 HyperBranch Medical Technology, Inc. Quervernetzte gele mit polyalkyleneimine, deren verwendung als medizinische geräte
WO2007088402A2 (en) 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
EP2143744A1 (de) * 2008-07-09 2010-01-13 Bayer MaterialScience AG Hydrophile, aliphatische Polyurethan-Schäume
WO2011059994A2 (en) * 2009-11-11 2011-05-19 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
EP2286017B1 (de) * 2009-12-14 2017-01-25 Aditya Birla Nuvo Limited Zusammensetzung und verfahren zur herstellung faltenfreier wollkleidungsstücke
GB201106774D0 (en) * 2011-04-21 2011-06-01 Occutec Ltd Polymers for contact lenses
CN109929088B (zh) * 2019-03-20 2021-07-23 嘉兴学院 一种双硫键聚氨酯及其制备方法和应用
CN113061227B (zh) * 2020-01-02 2022-09-20 万华化学集团股份有限公司 一种防水透湿的水性聚氨酯树脂、其制备方法及应用
CN113136020B (zh) * 2020-01-20 2022-08-05 万华化学集团股份有限公司 一种水性聚氨酯聚合物和制备方法、一种单组分水性聚氨酯防水涂料和制备方法及应用

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GB865726A (en) * 1957-08-13 1961-04-19 Bayer Ag Process for the manufacture of plastics from polyhydroxy compounds and polyisocyanates
US3114734A (en) * 1958-06-16 1963-12-17 Thiokol Chemical Corp Mercapto-terminated liquid polyurethane polymer
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US3723393A (en) * 1971-03-25 1973-03-27 Minnesota Mining & Mfg Amide-terminated polyether prepolymers and cured hydrophilic products thereof
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US3939123A (en) * 1974-06-18 1976-02-17 Union Carbide Corporation Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols
DE2621974A1 (de) * 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
US4094744A (en) * 1976-11-18 1978-06-13 W. R. Grace & Co. Water-dispersible protein/polyurethane reaction product
US4226935A (en) * 1978-08-07 1980-10-07 W. R. Grace & Co. Enzymatic diagnostic composition
US4182827A (en) * 1978-08-31 1980-01-08 Union Carbide Corporation Polyurethane hydrogels having enhanced wetting rates
US4293679A (en) * 1979-06-13 1981-10-06 W. R. Grace & Co. Composition and method of controlling solid polyurethane particle size with water reactant
DE3027198A1 (de) * 1980-07-18 1982-02-11 Bayer Ag, 5090 Leverkusen Feste, in wasser dispergierbare, isocyanatgruppen aufweisende kunststoffvorlaeufer, ein verfahren zur herstellung von waessrigen kunststoffdispersionen unter verwendung dieser kunststoffvorlaeufer, sowie die verwendung der kunststoffvorlaeufer als vernetzungsmittel fuer waessrige kunststoffdispersionen
US4439585A (en) * 1980-11-12 1984-03-27 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions as carrier for pharmacological agents
DE3312578A1 (de) * 1983-04-08 1984-10-11 Bayer Ag, 5090 Leverkusen Biologisch aktive zusammensetzung zur abwasser- und abluftreinigung
US4499233A (en) * 1983-05-03 1985-02-12 Nl Industries, Inc. Water dispersible, modified polyurethane and a thickened aqueous composition containing it
US4485227A (en) * 1983-06-16 1984-11-27 Howmedica, Inc. Biocompatible poly-(ether-urethane-urea) and process for its preparation
US4740528A (en) * 1986-07-18 1988-04-26 Kimberly-Clark Corporation Superwicking crosslinked polyurethane foam composition containing amino acid
CA1324857C (en) * 1987-01-12 1993-11-30 Gary M. Carlson Stabilized moisture curable polyurethane coatings

Also Published As

Publication number Publication date
EP0367362A3 (en) 1990-10-03
NZ231230A (en) 1991-10-25
JPH02209915A (ja) 1990-08-21
EP0367362B1 (de) 1994-06-15
US4940737A (en) 1990-07-10
AU620930B2 (en) 1992-02-27
EP0367362A2 (de) 1990-05-09
DE68916177D1 (de) 1994-07-21
AU4390889A (en) 1990-05-10

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