DE68911159T2 - Pyrido[2,3-d]pyrimidinderivate. - Google Patents

Pyrido[2,3-d]pyrimidinderivate.

Info

Publication number
DE68911159T2
DE68911159T2 DE89300046T DE68911159T DE68911159T2 DE 68911159 T2 DE68911159 T2 DE 68911159T2 DE 89300046 T DE89300046 T DE 89300046T DE 68911159 T DE68911159 T DE 68911159T DE 68911159 T2 DE68911159 T2 DE 68911159T2
Authority
DE
Germany
Prior art keywords
pyrido
pyrimidine derivatives
tetrahydropyrido
benzoyl
glutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89300046T
Other languages
English (en)
Other versions
DE68911159D1 (de
Inventor
Edward C Taylor
Chuan Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Princeton University
Original Assignee
Eli Lilly and Co
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co, Princeton University filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE68911159D1 publication Critical patent/DE68911159D1/de
Publication of DE68911159T2 publication Critical patent/DE68911159T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE89300046T 1988-02-05 1989-01-05 Pyrido[2,3-d]pyrimidinderivate. Expired - Fee Related DE68911159T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,908 US4889859A (en) 1988-02-05 1988-02-05 Pyrido[2,3-d]pyrimidine derivatives

Publications (2)

Publication Number Publication Date
DE68911159D1 DE68911159D1 (de) 1994-01-20
DE68911159T2 true DE68911159T2 (de) 1994-04-07

Family

ID=22561620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89300046T Expired - Fee Related DE68911159T2 (de) 1988-02-05 1989-01-05 Pyrido[2,3-d]pyrimidinderivate.

Country Status (7)

Country Link
US (1) US4889859A (de)
EP (1) EP0327190B1 (de)
JP (1) JP2848839B2 (de)
AT (1) ATE98243T1 (de)
CA (1) CA1340792C (de)
DE (1) DE68911159T2 (de)
ES (1) ES2061962T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins
US5030634A (en) * 1990-03-29 1991-07-09 Krumdieck Carlos L 10-deazaaminopterin: a new arthritis remittive drug
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
CA2184783A1 (en) * 1995-09-08 1997-03-09 William J. Gill Nonclassical antifolates
WO1997049705A1 (en) * 1996-06-25 1997-12-31 The Trustees Of Princeton University 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN114478345A (zh) * 2022-02-10 2022-05-13 中瀚(齐河县)生物医药科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI66866C (fi) * 1979-06-14 1984-12-10 Wellcome Found Foerfarande foer framstaellning av antiproliferativa 2,4-diamino-6-(dialkoxibensyl)pyrido(2,3-d)pyrimidiner
US4460591A (en) 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
JP2848839B2 (ja) 1999-01-20
EP0327190A1 (de) 1989-08-09
ES2061962T3 (es) 1994-12-16
ATE98243T1 (de) 1993-12-15
JPH01226886A (ja) 1989-09-11
US4889859A (en) 1989-12-26
EP0327190B1 (de) 1993-12-08
CA1340792C (en) 1999-10-19
DE68911159D1 (de) 1994-01-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee