ES2061962T3 - Derivados de pirido (2,3-d) pirimidina. - Google Patents
Derivados de pirido (2,3-d) pirimidina.Info
- Publication number
- ES2061962T3 ES2061962T3 ES89300046T ES89300046T ES2061962T3 ES 2061962 T3 ES2061962 T3 ES 2061962T3 ES 89300046 T ES89300046 T ES 89300046T ES 89300046 T ES89300046 T ES 89300046T ES 2061962 T3 ES2061962 T3 ES 2061962T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- pirimidina
- pirido
- tetrahydropyrido
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LOS DERIVADOS DE N - (2 - (5, 6, 7, 8 - TETRAHIDRO - PIRIDO - (2, 3, - D) PIRIMIDIN - 6 - IL) - ALQUIL) BENZOIL - L - ACIDO GLUTAMICO SON AGENTES ANTINEOPLASTICOS. ES TIPICO EL N - (2 - FLUORO - 4 - (2 - AMINO - 4 - HIDROXI - 5, 6, 7, 8 - TETRAHIDROPIRIDO - (2, 3 - D) PIRIMIDIN - 6 - IL) ETIL) BENZOIL) - L ACIDO GLUTAMICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/156,908 US4889859A (en) | 1988-02-05 | 1988-02-05 | Pyrido[2,3-d]pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061962T3 true ES2061962T3 (es) | 1994-12-16 |
Family
ID=22561620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89300046T Expired - Lifetime ES2061962T3 (es) | 1988-02-05 | 1989-01-05 | Derivados de pirido (2,3-d) pirimidina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4889859A (es) |
EP (1) | EP0327190B1 (es) |
JP (1) | JP2848839B2 (es) |
AT (1) | ATE98243T1 (es) |
CA (1) | CA1340792C (es) |
DE (1) | DE68911159T2 (es) |
ES (1) | ES2061962T3 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5028608A (en) * | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
US4996207A (en) * | 1990-01-18 | 1991-02-26 | Nair Madhavan G | Three new non-polyglutamatable deazaaminopterins |
US5030634A (en) * | 1990-03-29 | 1991-07-09 | Krumdieck Carlos L | 10-deazaaminopterin: a new arthritis remittive drug |
US5145854A (en) * | 1991-11-27 | 1992-09-08 | Nair Madhavan G | 1-formyl-5,8,10-trideazafolates |
US5594139A (en) * | 1993-01-29 | 1997-01-14 | Agouron Pharmaceuticals, Inc. | Processes for preparing antiproliferative garft-inhibiting compounds |
US5608082A (en) * | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
US5593999A (en) * | 1995-06-07 | 1997-01-14 | Nair; Madhavan G. | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) |
CA2184783A1 (en) * | 1995-09-08 | 1997-03-09 | William J. Gill | Nonclassical antifolates |
WO1997049705A1 (en) * | 1996-06-25 | 1997-12-31 | The Trustees Of Princeton University | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
PT3395372T (pt) | 2009-02-20 | 2022-05-05 | Enhanx Biopharm Inc | Sistema de entrega de medicamentos à base de glutationa |
KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN114478345A (zh) * | 2022-02-10 | 2022-05-13 | 中瀚(齐河县)生物医药科技有限公司 | 一种(r)-2-(2,5-二氟苯基)吡咯烷的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI66866C (fi) * | 1979-06-14 | 1984-12-10 | Wellcome Found | Foerfarande foer framstaellning av antiproliferativa 2,4-diamino-6-(dialkoxibensyl)pyrido(2,3-d)pyrimidiner |
US4460591A (en) | 1982-08-26 | 1984-07-17 | Sri International | 8,10-Dideazaminopterins |
US4684653A (en) * | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
ZA861235B (en) * | 1985-03-08 | 1986-10-29 | Univ Princeton | Pyrido(2,3-d)pyrimidine derivatives |
NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
-
1988
- 1988-02-05 US US07/156,908 patent/US4889859A/en not_active Expired - Lifetime
-
1989
- 1989-01-05 DE DE89300046T patent/DE68911159T2/de not_active Expired - Fee Related
- 1989-01-05 EP EP89300046A patent/EP0327190B1/en not_active Expired - Lifetime
- 1989-01-05 AT AT89300046T patent/ATE98243T1/de not_active IP Right Cessation
- 1989-01-05 ES ES89300046T patent/ES2061962T3/es not_active Expired - Lifetime
- 1989-01-12 CA CA000588042A patent/CA1340792C/en not_active Expired - Fee Related
- 1989-02-03 JP JP1025616A patent/JP2848839B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2848839B2 (ja) | 1999-01-20 |
EP0327190A1 (en) | 1989-08-09 |
ATE98243T1 (de) | 1993-12-15 |
JPH01226886A (ja) | 1989-09-11 |
US4889859A (en) | 1989-12-26 |
EP0327190B1 (en) | 1993-12-08 |
CA1340792C (en) | 1999-10-19 |
DE68911159T2 (de) | 1994-04-07 |
DE68911159D1 (de) | 1994-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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