DE68902576T2 - Verwendung von thiadiazol-oxid-derivaten zur herstellung einer pharmazeutischen zusammensetzung fuer die behandlung von stoerungen der gastrointestinalen mobilitaet. - Google Patents
Verwendung von thiadiazol-oxid-derivaten zur herstellung einer pharmazeutischen zusammensetzung fuer die behandlung von stoerungen der gastrointestinalen mobilitaet.Info
- Publication number
- DE68902576T2 DE68902576T2 DE8989108509T DE68902576T DE68902576T2 DE 68902576 T2 DE68902576 T2 DE 68902576T2 DE 8989108509 T DE8989108509 T DE 8989108509T DE 68902576 T DE68902576 T DE 68902576T DE 68902576 T2 DE68902576 T2 DE 68902576T2
- Authority
- DE
- Germany
- Prior art keywords
- compound
- disorders
- compounds
- treatment
- gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 5
- 230000002496 gastric effect Effects 0.000 title description 9
- XWMXMWHHTIEXRE-UHFFFAOYSA-N thiadiazole 1-oxide Chemical class O=S1C=CN=N1 XWMXMWHHTIEXRE-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 51
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 20
- 206010021518 Impaired gastric emptying Diseases 0.000 claims abstract description 13
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims abstract description 10
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 7
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 4
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- 230000004899 motility Effects 0.000 claims description 13
- 208000001288 gastroparesis Diseases 0.000 claims description 4
- 239000008177 pharmaceutical agent Substances 0.000 claims description 3
- MJQAXXDFXQOPMJ-UHFFFAOYSA-N 1-oxo-3-n-[2-[[5-(piperidin-1-ylmethyl)furan-2-yl]methylsulfanyl]ethyl]-1,2,5-thiadiazole-3,4-diamine Chemical compound NC1=NS(=O)N=C1NCCSCC(O1)=CC=C1CN1CCCCC1 MJQAXXDFXQOPMJ-UHFFFAOYSA-N 0.000 claims description 2
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- IRQVJPHZDYMXNW-UHFFFAOYSA-N metoclopramide dihydrochloride monohydrate Chemical compound O.[Cl-].[Cl-].CC[NH+](CC)CCNC(=O)C1=CC(Cl)=C([NH3+])C=C1OC IRQVJPHZDYMXNW-UHFFFAOYSA-N 0.000 description 2
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- KUNGRZBHIYQKKH-UHFFFAOYSA-N 2-[[5-(piperidin-1-ylmethyl)furan-2-yl]methylsulfanyl]ethanamine Chemical compound O1C(CSCCN)=CC=C1CN1CCCCC1 KUNGRZBHIYQKKH-UHFFFAOYSA-N 0.000 description 1
- ZRSLQBDTGLCFJJ-UHFFFAOYSA-N 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide Chemical compound COC1=NS(=O)(=O)N=C1OC ZRSLQBDTGLCFJJ-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
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- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
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- OJYGBLRPYBAHRT-IPQSZEQASA-N chloralose Chemical compound O1[C@H](C(Cl)(Cl)Cl)O[C@@H]2[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]21 OJYGBLRPYBAHRT-IPQSZEQASA-N 0.000 description 1
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- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 description 1
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- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
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- 239000006194 liquid suspension Substances 0.000 description 1
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- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
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- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 229960000923 metoclopramide hydrochloride Drugs 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- 235000013336 milk Nutrition 0.000 description 1
- 239000013580 millipore water Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
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- 239000000472 muscarinic agonist Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
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- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
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- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 210000001187 pylorus Anatomy 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 238000013222 sprague-dawley male rat Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/193,025 US4829073A (en) | 1988-05-12 | 1988-05-12 | Thiadiazole oxides for treating gastrointestinal motility disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68902576D1 DE68902576D1 (de) | 1992-10-01 |
| DE68902576T2 true DE68902576T2 (de) | 1993-01-21 |
Family
ID=22711984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989108509T Expired - Fee Related DE68902576T2 (de) | 1988-05-12 | 1989-05-11 | Verwendung von thiadiazol-oxid-derivaten zur herstellung einer pharmazeutischen zusammensetzung fuer die behandlung von stoerungen der gastrointestinalen mobilitaet. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4829073A (https=) |
| EP (1) | EP0341722B1 (https=) |
| JP (1) | JPH01313424A (https=) |
| AT (1) | ATE79753T1 (https=) |
| DE (1) | DE68902576T2 (https=) |
| ES (1) | ES2034484T3 (https=) |
| GR (1) | GR3005563T3 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK60493D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
| AU699008B2 (en) * | 1995-05-18 | 1998-11-19 | Zeria Pharmaceutical Co., Ltd. | Aminothiazole derivative, medicament containing the same, and intermediate for preperation of said compound |
| JP4153043B2 (ja) * | 1996-10-24 | 2008-09-17 | ゼリア新薬工業株式会社 | 置換ベンゾイルアミノチアゾール誘導体及びそれを含有する医薬 |
| TWI256314B (en) * | 2000-02-09 | 2006-06-11 | Mitsubishi Pharma Corp | Preventive-therapeutical medicament for gastroesophageal reflux disease |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3175201D1 (en) * | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| US4394508A (en) * | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| US4471122A (en) * | 1981-03-03 | 1984-09-11 | Bristol-Myers Company | Thiadiazole histamine H2 -antagonists |
| US4567191A (en) * | 1983-06-07 | 1986-01-28 | Merck & Co., Inc. | Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors |
-
1988
- 1988-05-12 US US07/193,025 patent/US4829073A/en not_active Expired - Fee Related
-
1989
- 1989-04-13 JP JP1091988A patent/JPH01313424A/ja active Granted
- 1989-05-11 DE DE8989108509T patent/DE68902576T2/de not_active Expired - Fee Related
- 1989-05-11 EP EP89108509A patent/EP0341722B1/en not_active Expired - Lifetime
- 1989-05-11 ES ES198989108509T patent/ES2034484T3/es not_active Expired - Lifetime
- 1989-05-11 AT AT89108509T patent/ATE79753T1/de not_active IP Right Cessation
-
1992
- 1992-08-31 GR GR920401726T patent/GR3005563T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0480004B2 (https=) | 1992-12-17 |
| US4829073A (en) | 1989-05-09 |
| EP0341722A2 (en) | 1989-11-15 |
| ES2034484T3 (es) | 1993-04-01 |
| ATE79753T1 (de) | 1992-09-15 |
| DE68902576D1 (de) | 1992-10-01 |
| EP0341722B1 (en) | 1992-08-26 |
| JPH01313424A (ja) | 1989-12-18 |
| EP0341722A3 (en) | 1990-10-10 |
| GR3005563T3 (https=) | 1993-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |