DE683866C - Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide - Google Patents

Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide

Info

Publication number
DE683866C
DE683866C DEL94408D DEL0094408D DE683866C DE 683866 C DE683866 C DE 683866C DE L94408 D DEL94408 D DE L94408D DE L0094408 D DEL0094408 D DE L0094408D DE 683866 C DE683866 C DE 683866C
Authority
DE
Germany
Prior art keywords
aminobenzenesulfonamide
aqueous solutions
production
parts
durable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEL94408D
Other languages
German (de)
Inventor
Dr Johannes Riesenberg
Dr Irene Weindling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharma Dr Laboschin G M B
Original Assignee
Labopharma Dr Laboschin G M B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharma Dr Laboschin G M B filed Critical Labopharma Dr Laboschin G M B
Priority to DEL94408D priority Critical patent/DE683866C/en
Application granted granted Critical
Publication of DE683866C publication Critical patent/DE683866C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung haltbarer wäßriger Lösungen von p-Aminobenzolsulfonamid Das therapeutisch wirksame p-Aminobenzolsulfonamid weist den Nachteil auf, daß es nur in heißem Wasser löslich ist, aber beim Ablkühlen wieder ausfällt. Man kann hiermit infolgedessen keine haltbaren Lösungen in tropfbarer bzw. injizierbarer Form herstellen.Process for the preparation of stable aqueous solutions of p-aminobenzenesulfonamide The therapeutically active p-aminobenzenesulfonamide has the disadvantage that it is only soluble in hot water, but precipitates again on cooling. One can consequently no long-lasting solutions in drip or injectable Make shape.

Durch das Verfahren der vorliegenden Erfindung gelingt es nun, haltbare wäßrige Lösungen des p-Aminobsenzolsulfonamids in für therapeutische Zwecke ausreichender Konzentration unter Verwendung von geeigneten Lösungsvermittlern zu erhalten. The method of the present invention now makes it possible to obtain durable aqueous solutions of the p-aminobenzenesulfonamide in sufficient for therapeutic purposes To obtain concentration using suitable solubilizers.

Es wurde gefunden, daß die Herstellung einer wäßrigen, hitzebeständigen und haltbar, p p-Aminobenzolsulfonamidlösung dadurch möglich wird, daß man p-Aminobenzolsulfonamid mit Glucose und Hexamethylentetramin zusammen verreibt und in der Wärme in Wasser löst. It has been found that the preparation of an aqueous, heat-resistant and durable, p-aminobenzenesulfonamide solution is made possible by using p-aminobenzenesulfonamide rubbed together with glucose and hexamethylenetetramine and in the warmth in water solves.

Die lösungsvermittelnden Zusatzstoffe wirken hierbei nicht störend, da sile zum T, eil selbst günstige therapeutische Eigenschaften besitzen, die die Wirkung des p-Aminoblenzolsulfonamids unterstützen. The solubilizing additives do not have a disruptive effect here, because they themselves have beneficial therapeutic properties that the Support the effect of p-aminoblenesulfonamide.

Zur Herstellung der Lösungen genügen im allgemeinen mengen von 2,5% p-Aminobenzolsulfonamid, 10% Glucose und 7,5% Hexamethylentetramin. An Stelle von Glucose kann man auch gleiche Mengen der Disaccharide: Saccharose, Lactose sowie - Maltose verwenden, ferner auch folgender Monosaccharide der hexosereihe: Fructose und Invertzucker (das Gemisch von Glucose und Fructose) und auch der Hexite: Mannit und Sorbit sowie auch der Gemische der genannten Stoffe. For the preparation of the solutions, amounts of 2.5% are generally sufficient p-aminobenzenesulfonamide, 10% glucose and 7.5% hexamethylenetetramine. Instead of Glucose can also have equal amounts of the disaccharides: sucrose, lactose as well - Use maltose, also the following monosaccharides of the hexose series: fructose and invert sugar (the mixture of glucose and fructose) and also the hexite: mannitol and Sorbitol as well as mixtures of the substances mentioned.

Die erhaltenen Lösungen eignen sich zur Verwendung in tropibarer und injizierbarer Form. The solutions obtained are suitable for use in tropibarer and injectable form.

Beispiele 1. 1 Teil p-aminobenzolsulfonamid, 4 Teile Glucose und 3 Teile Hexamethylentetramin werden verrieben und in 40 Teilen Wasser heiß gelöst. Die Lösung bleibt nachdemAbkühlen unverändert. Bei tiefen Temperaturen tritt eine leichte Trübung auf, die aber nach Erwärmen auf Zimmertemperatur wieder verschwindet. Examples 1. 1 part of p-aminobenzenesulfonamide, 4 parts of glucose and 3 parts of hexamethylenetetramine are triturated and dissolved in 40 parts of hot water. The solution remains unchanged after cooling. At low temperatures a slight cloudiness, which disappears again after warming to room temperature.

2. I Teil p-Aminobenzolsulfonamid, 4 Teile Milchzucker und 3 Teile Hexamethylentetramin werden wie oben behandelt. 2. I part of p-aminobenzenesulfonamide, 4 parts of milk sugar and 3 parts Hexamethylenetetramine are treated as above.

3. I Teil p-Aminobenzolsulfonamid, 4 Teile Mannit und 4 Teile Hexdamethylenetramin werden in 40 Teilen einer Mischung aus 15% Alkohol, 12,5% Glycerin und 72,5% Wasser in der Wärme gelöst. Die Lösung bleibt nach dem Abkühlen unverändert. 3. I part of p-aminobenzenesulfonamide, 4 parts of mannitol and 4 parts of hexdamethylene tetramine are in 40 parts of a mixture of 15% alcohol, 12.5% glycerin and 72.5% water dissolved in the warmth. The solution remains unchanged after cooling.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von haltbaren wäßrigen Lösungen von p-Aminobenzolsulfonamid, gekennzeichnet durch die Verwendung von hexamethylentetramin neben Zuckern und/oder Hexiten als Lösungsvermittler. PATENT CLAIM: Process for the production of durable aqueous Solutions of p-aminobenzenesulfonamide, characterized by the use of hexamethylenetetramine in addition to sugars and / or hexites as solubilizers.
DEL94408D 1938-03-06 1938-03-06 Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide Expired DE683866C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEL94408D DE683866C (en) 1938-03-06 1938-03-06 Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEL94408D DE683866C (en) 1938-03-06 1938-03-06 Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide

Publications (1)

Publication Number Publication Date
DE683866C true DE683866C (en) 1939-11-17

Family

ID=7287873

Family Applications (1)

Application Number Title Priority Date Filing Date
DEL94408D Expired DE683866C (en) 1938-03-06 1938-03-06 Process for the production of durable aqueous solutions of p-aminobenzenesulfonamide

Country Status (1)

Country Link
DE (1) DE683866C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2613170A (en) * 1944-03-02 1952-10-07 Physiological Chemicals Compan Calcium sulfanilamide preparations
DE1056136B (en) * 1956-12-21 1959-04-30 Bayer Ag Process for the preparation of a molecular compound from p-aminobenzenesulfonylthiourea (sulfathiourea) and hexamethylenetetramine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2613170A (en) * 1944-03-02 1952-10-07 Physiological Chemicals Compan Calcium sulfanilamide preparations
DE1056136B (en) * 1956-12-21 1959-04-30 Bayer Ag Process for the preparation of a molecular compound from p-aminobenzenesulfonylthiourea (sulfathiourea) and hexamethylenetetramine

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