DE529423C - Process for the production of concentrated aqueous solutions of tribromomethyl alcohol - Google Patents
Process for the production of concentrated aqueous solutions of tribromomethyl alcoholInfo
- Publication number
- DE529423C DE529423C DET36063D DET0036063D DE529423C DE 529423 C DE529423 C DE 529423C DE T36063 D DET36063 D DE T36063D DE T0036063 D DET0036063 D DE T0036063D DE 529423 C DE529423 C DE 529423C
- Authority
- DE
- Germany
- Prior art keywords
- aqueous solutions
- alcohol
- concentrated aqueous
- production
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung konzentrierter wäßriger Lösungen des Tribromäthylalkohols Bei Verwendung. des Tribromäthylalkohols als rektales Dämmetschlafmittel oder Narkotikum ist die Auflösung des festen Produkts in Wasser mit erheblichen Schwierigkeiten verbunden, da die Auflösung im kalten Wasser nur sehr langsam vor sich geht und bei erwärmtem Wasser die Gefahr einer Zersetzung vorhanden ist, wenn das Wasser über eine besämmte Temperatur hinaus erwärmt wird.Process for the preparation of concentrated aqueous solutions of tribromoethyl alcohol Using. of tribromoethyl alcohol as a rectal sleep aid or narcotic dissolving the solid product in water is with considerable difficulty connected, since the dissolution in cold water is very slow and with heated water there is a risk of decomposition if the water is heated beyond an insulated temperature.
Um nun,eine wäßrige Lösung des Tribromäthylalkohols zu erhalten" die die geschilderten Nachteile nicht mehr besitzt, hat man bereits den Tribromäthylalkohol mit tertiären Alkoholen, wie Amylenhydrat, oder mit sekundären Alkoho'len behandelt.In order now to obtain an aqueous solution of tribromoethyl alcohol "the no longer has the disadvantages described, one already has tribromoethyl alcohol treated with tertiary alcohols, such as amylene hydrate, or with secondary alcohols.
Es wurde nun gefunden, daß sich konzentrierte wäßrige Lösungen von Tribromäthylalkohol herstellen lassen, wenn man Tribromäthylalkohol mit buttersaurem Ammonium zusammen auflöst. In reinem Wasser löst sich Tribromäthylalkohol bis zu 3 v. H. Durch Zusatz von bu-tt-ersaurem Ammonium löst sich aber i g Tribromäthylalkohol in 0,5 ccm Wasser schon bei 3 5' bis 40' C restlos auf, und zwar sind in dem vorliegenden Falle nur o,5 bis i g des buttersauren Ammoniums zur Erhöhung der Löslichkeit erforderlich, wodurch auch die therapeutische Verwendbarkeit des Tribromäthylalkohols# erleichtertwird.It has now been found that concentrated aqueous solutions of tribromoethyl alcohol can be prepared if tribromoethyl alcohol is dissolved together with butyrate ammonium. Tribromoethyl alcohol dissolves up to 3 % in pure water. H. However, by adding butt-acidic ammonium, 1 g of tribromoethyl alcohol dissolves completely in 0.5 cc of water at 35 to 40 ° C , and in the present case only 0.5 to 1 g of it are dissolved butyric acid ammonium is required to increase the solubility, which also facilitates the therapeutic use of tribromoethyl alcohol #.
Analog dem obigen Beispiel lassen sich die Lösungen auch mit anderen Alkalisalzen der Buttersäure herstellen, z. B. Natriumbutyrat 2,o, Tribromäthylalkohol i,o, Wasser 2,o; Kaliunibutyrat i,o, Tribromäthylalkohol i,o, Wasser 0, 5. Analogously to the above example, the solutions can also be prepared with other alkali salts of butyric acid, e.g. B. sodium butyrate 2, o, tribromoethyl alcohol i, o, water 2, o; Potassium butyrate i, o, tribromoethyl alcohol i, o, water 0.5 .
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET36063D DE529423C (en) | 1928-12-05 | 1928-12-05 | Process for the production of concentrated aqueous solutions of tribromomethyl alcohol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET36063D DE529423C (en) | 1928-12-05 | 1928-12-05 | Process for the production of concentrated aqueous solutions of tribromomethyl alcohol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE529423C true DE529423C (en) | 1931-07-13 |
Family
ID=7559581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DET36063D Expired DE529423C (en) | 1928-12-05 | 1928-12-05 | Process for the production of concentrated aqueous solutions of tribromomethyl alcohol |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE529423C (en) |
-
1928
- 1928-12-05 DE DET36063D patent/DE529423C/en not_active Expired
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