DE632279C - Process for the production of aseptic aqueous hexamethylenetetramine solutions - Google Patents

Process for the production of aseptic aqueous hexamethylenetetramine solutions

Info

Publication number
DE632279C
DE632279C DEI44195D DEI0044195D DE632279C DE 632279 C DE632279 C DE 632279C DE I44195 D DEI44195 D DE I44195D DE I0044195 D DEI0044195 D DE I0044195D DE 632279 C DE632279 C DE 632279C
Authority
DE
Germany
Prior art keywords
hexamethylenetetramine
solutions
production
aseptic aqueous
aqueous hexamethylenetetramine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI44195D
Other languages
German (de)
Inventor
Dr Max Bockmuehl
Dr Gustav Ehrhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI44195D priority Critical patent/DE632279C/en
Application granted granted Critical
Publication of DE632279C publication Critical patent/DE632279C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung von keimfreien wäßrigen Hexamethylentetraminlösungen Gegenstand des Patents 574 973 ist ein Verfahren zur Herstellung von keimfreien Hexamethylentetraminlösungen, welches dadurch gekennzeichnet ist, daß man wäßrige Lösungen von camphersaurem Hexamethylentetramin mit oder ohne Zusatz von Hexamethylentetramin in geschlossenen Gefäßen erhitzt.Process for the preparation of sterile aqueous hexamethylenetetramine solutions The subject of the patent 574 973 is a process for the production of aseptic Hexamethylenetetramine solutions, which is characterized in that aqueous Solutions of camphoric hexamethylenetetramine with or without the addition of hexamethylenetetramine heated in closed vessels.

Es wurde nun gefunden, daß die Sterilisierbarkeit von Hexamethylentetraminlösungen durch Erhitzen nicht auf -das camphersaure Hexamethylentetramin beschränkt ist, sondern daß auch andere Salze des Hexamethylentetramins, wie z. B. das sulfosalicylsaure, das methylencitronensaure Hexamethylentetramin und andere, durch Erhitzen in geschlossenen Gefäßen sterilisiert werden können, ohne daß eine Zersetzung eintritt. Den wäßrigen Lösungen der Salze kann man gegebenenfalls noch freies Hexamethylentetramin zusetzen. Man hat bereits Lösungen von Salzen des Hexamethylentetramins in offenen Gefäßen erhitzt. Dabei tritt jedoch im Gegensatz zu dem Erhitzen in geschlossenen Gefäßen Zersetzung ein, die sich in Gewichtsverlusten der gelösten Substanz sowie in alkalischer Reaktion der, ursprünglich sauer reagierenden Lösung geltend macht.It has now been found that the sterilizability of hexamethylenetetramine solutions by heating is not limited to -das camphoric hexamethylenetetramine, but that other salts of hexamethylenetetramine, such as. B. sulfosalicylic acid, methylenecitric acid, hexamethylenetetramine and others can be sterilized by heating in closed vessels without decomposition. If appropriate, free hexamethylenetetramine can also be added to the aqueous solutions of the salts. Solutions of salts of hexamethylenetetramine have already been heated in open vessels. However, in this case closed vessels occurs in contrast to a heating decomposition, which asserts itself in weight loss of the solute as well as in an alkaline reaction of the originally acidic solution.

Claims (1)

PATENTANSPRUCH; Verfahren zur Herstellung von keimfreien wäßrigen Hexamethylentetraminlösungen gemäß Patent 574973, dadurch gekennzeichnet, daß man hier an Stelle von camphersaurem Hexamethylentetramin andere Salze des Hexamethylentetramins,, gegebenenfalls unter Zusatz von Hexamethylentetramin, in wäßriger Lösung im geschlossenen Gefäß erhitzt.PATENT CLAIM; Process for the production of sterile aqueous hexamethylenetetramine solutions according to patent 574973, characterized in that instead of camphoric hexamethylenetetramine other salts of hexamethylenetetramine, optionally with the addition of hexamethylenetetramine, are heated in an aqueous solution in a closed vessel.
DEI44195D 1932-04-13 1932-04-13 Process for the production of aseptic aqueous hexamethylenetetramine solutions Expired DE632279C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI44195D DE632279C (en) 1932-04-13 1932-04-13 Process for the production of aseptic aqueous hexamethylenetetramine solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI44195D DE632279C (en) 1932-04-13 1932-04-13 Process for the production of aseptic aqueous hexamethylenetetramine solutions

Publications (1)

Publication Number Publication Date
DE632279C true DE632279C (en) 1936-07-06

Family

ID=7191223

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI44195D Expired DE632279C (en) 1932-04-13 1932-04-13 Process for the production of aseptic aqueous hexamethylenetetramine solutions

Country Status (1)

Country Link
DE (1) DE632279C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3015068A1 (en) * 1980-04-18 1981-10-29 Claudius Peters Ag, 2000 Hamburg Silo with two storage sPaces separated by wall - has outlet chamber of one below outlet cone of other space

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3015068A1 (en) * 1980-04-18 1981-10-29 Claudius Peters Ag, 2000 Hamburg Silo with two storage sPaces separated by wall - has outlet chamber of one below outlet cone of other space

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