DE631176C - Process for the preparation of aqueous solutions of medicines - Google Patents

Process for the preparation of aqueous solutions of medicines

Info

Publication number
DE631176C
DE631176C DEI41974D DEI0041974D DE631176C DE 631176 C DE631176 C DE 631176C DE I41974 D DEI41974 D DE I41974D DE I0041974 D DEI0041974 D DE I0041974D DE 631176 C DE631176 C DE 631176C
Authority
DE
Germany
Prior art keywords
aqueous solutions
preparation
medicines
phenyl
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI41974D
Other languages
German (de)
Inventor
Dr Max Bockmuehl
Dr Leonhard Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI41974D priority Critical patent/DE631176C/en
Application granted granted Critical
Publication of DE631176C publication Critical patent/DE631176C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Darstellung wäßriger Lösungen von Arzneimitteln Im Patent 585 532 ist ein Verfahren zur Darstellung wäßriger Lösungen von i-Phenyl-2 # 3 - dialkyl-q.-dialkylaminopyrazolonen mit i-phenyl-2 #3-dialkylpyrazolon-4-aminomethansulfonsauren Salzen und deren Derivaten beschrieben, -welches durch die Verwendung von Urethanen der niederen Alkohole als Lösungsvermittler gekennzeichnet ist.Process for the preparation of aqueous solutions of pharmaceuticals In the patent 585 532 is a method for the preparation of aqueous solutions of i-phenyl-2 # 3 - dialkyl-q.-dialkylaminopyrazolones with i-phenyl-2 # 3-dialkylpyrazolone-4-aminomethanesulfonic acids Salts and their derivatives described -which through the use of urethanes of the lower alcohols is characterized as solubilizers.

Es wurde nun gefunden, daß auch die Löslichkeit schlafmachend wirkender Säureamide in wäßrigen Lösungen von i-phenyl-2 # 3-dialkylpyrazolon - 4 - aminomethansulfonsauren Salzen oder deren Derivaten durch Zusatz von Urethanen erhöht wird. Es können auf diese Weise die als lieber- und schmerzstillende Mittel bekannten i-phenyl-2 # 3-dialkylpyrazolon-4-aminomethansulfonsauren Salze zusammen mit schlafmachend wirkenden Säureamiden, die bisher wegen ihrer schweren Löslichkeit nur peroral anwendbar waren, auf parenteralem Wege angewandt werden. Beispiele i. io g Diäthylallylacetamid und. 4o g i - phenyl - 2 # 3 - dimethylpyrazolon - 4-methylaminomethansulfonsaures Natrium werden nach Zusatz von 35 g Urethan in Wasser zu ioo Volumteilen gelöst. Die Lösung enthält i o % Diäthylallylacetamid, während die Löslichkeit dieses Stoffes in Wasser i : i ao beträgt.It has now been found that the solubility also has a sleep-inducing effect Acid amides in aqueous solutions of i-phenyl-2 # 3-dialkylpyrazolon - 4 - aminomethanesulfonic acids Salts or their derivatives is increased by adding urethanes. It can on in this way the i-phenyl-2 # 3-dialkylpyrazolon-4-aminomethanesulphonic acids known as preferential and analgesic agents Salts together with sleep-inducing acid amides, which were previously used because of their heavy Solubility could only be used orally, can be used by the parenteral route. Examples i. io g diethylallylacetamide and. 40 g of i-phenyl-2 # 3-dimethylpyrazolone - Sodium 4-methylaminomethanesulfonic acid is converted into Water dissolved to 100 parts by volume. The solution contains 10% diethylallylacetamide, while the solubility of this substance in water is i: i ao.

2. io g Diäthylallylacetamid und 4o g i - phenyl - 2 # 3 - dimethylpyrazolon - 4 - aminomethansulfonsaures Natrium -werden nach Zusatz von 3o g Urethan in Wasser zu i oo Volumteilen gelöst.2. 10 g diethyl allylacetamide and 40 g i - phenyl - 2 # 3 - dimethylpyrazolone - 4 - Sodium aminomethanesulfonic acid becomes after the addition of 30 g urethane in water solved to i oo parts by volume.

Claims (1)

PATEN TAIlsi'RUCI3: Abänderung des Verfahrens des Patents 585 532, dadurch gekennzeichnet, daßman an Stelle von i-Phenyl-2 # 3-dialkyl-4-dialkylaminopyrazolonen schlafmachend wirkende Säureamide verwendet. PATEN TAIlsi'RUCI3: Modification of the method of patent 585 532, characterized in that sleep-inducing acid amides are used in place of i-phenyl-2 # 3-dialkyl-4-dialkylaminopyrazolones.
DEI41974D 1931-07-01 1931-07-01 Process for the preparation of aqueous solutions of medicines Expired DE631176C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI41974D DE631176C (en) 1931-07-01 1931-07-01 Process for the preparation of aqueous solutions of medicines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI41974D DE631176C (en) 1931-07-01 1931-07-01 Process for the preparation of aqueous solutions of medicines

Publications (1)

Publication Number Publication Date
DE631176C true DE631176C (en) 1936-06-15

Family

ID=7190669

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI41974D Expired DE631176C (en) 1931-07-01 1931-07-01 Process for the preparation of aqueous solutions of medicines

Country Status (1)

Country Link
DE (1) DE631176C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE903624C (en) * 1952-05-08 1954-02-08 Aschaffenburger Zellstoffwerke Process for the preparation of durable, injectable solutions of 1-phenyl-2, 3-dialkyl-4-dialkylamino-5-pyrazolones
DE937373C (en) * 1952-11-08 1956-01-05 Hoechst Ag Process for the production of aqueous pharmaceutical solutions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE903624C (en) * 1952-05-08 1954-02-08 Aschaffenburger Zellstoffwerke Process for the preparation of durable, injectable solutions of 1-phenyl-2, 3-dialkyl-4-dialkylamino-5-pyrazolones
DE937373C (en) * 1952-11-08 1956-01-05 Hoechst Ag Process for the production of aqueous pharmaceutical solutions

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