DE871496C - Process for the preservation of concentrated solutions of p-aminobenzene sulfonamide or its decoctions - Google Patents
Process for the preservation of concentrated solutions of p-aminobenzene sulfonamide or its decoctionsInfo
- Publication number
- DE871496C DE871496C DEV1853D DEV0001853D DE871496C DE 871496 C DE871496 C DE 871496C DE V1853 D DEV1853 D DE V1853D DE V0001853 D DEV0001853 D DE V0001853D DE 871496 C DE871496 C DE 871496C
- Authority
- DE
- Germany
- Prior art keywords
- preservation
- concentrated solutions
- decoctions
- aminobenzene sulfonamide
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Haltbarmachung konzentrierter Lösungen des p-Aminobenzolsulfonamids bzw. dessen Abkömmlingen Konzentrierte Lösungen des p-Aminobenzolsulfonamids und solche seiner Abkömmlinge, wie sie beispielsweise mit Hilfe von Acetamid oder Formamid alsLösungsvermittlerhergestellt werden, neigen bei längerer Aufbewahrung zum Auskristallisieren.Process for the preservation of concentrated solutions of p-aminobenzenesulfonamide or its derivatives Concentrated solutions of p-aminobenzene sulfonamide and those of its descendants, for example with the help of acetamide or formamide are produced as solubilizers, tend to crystallize out after prolonged storage.
Es wurde nun die überraschende und in keiner Weise vorauszusehende Beobachtung gemacht, daß durch mehrmaliges Erhitzen derartiger Lösungen auf So bis go° oder darüber in kurzen Zeitabständen eine völlige Haltbarkeit erzielt werden kann. Auch bei sehr starker Abkühlung und jahrelanger Aufbewahrung bleibt bei derartigen mehrfach erhitzten Lösungen die völlige Haltbarkeit erhalten.It now became the most surprising and in no way predictable Observation made that by repeatedly heating such solutions to So to go ° or above, complete durability can be achieved in short time intervals can. Even with very strong cooling and storage for years, it remains with such Repeatedly heated solutions retain their full shelf life.
Die auf die beschriebene Weise erzielte Haltbarkeit der Lösungen ist für praktische Zwecke um so wichtiger, als einmal gebildete Kristalle sich nur sehr schwer auflösen und nicht durch schwaches Erwärmen, wie dies bei manchen Ampullenlösungen möglich ist, wieder in Lösung gebracht werden können.The shelf life of the solutions achieved in the manner described is For practical purposes it is all the more important that crystals, once formed, only differ greatly Difficult to dissolve and not by gentle warming, as is the case with some ampoule solutions is possible, can be brought back into solution.
Beispiel Eine mit Hilfe von Formamid als Lösungsvermittler hergestellte Lösung, die in roo ccm ro g p-Aminobenzolsulfonamid und 22,8 g p-Aminobenzolsulfonamidosulfosalicylat enthält, wird in Ampullen abgefüllt. Diese werden durch Erhitzen auf 9o° sterilisiert; dieser Vorgang wird nach 2 und nach q. Tagen wiederholt. Die so erhaltenen Ampullen sind haltbar und können sowohl für intramuskuläre und intravenöse Anwendung benutzt werden. -Example One produced with the help of formamide as a solubilizer Solution that is in roo ccm ro g p-aminobenzenesulfonamide and 22.8 g p-aminobenzenesulfonamidosulfosalicylate contains, is filled into ampoules. These are sterilized by heating to 90 °; this process is carried out after 2 and after q. Days repeated. The ampoules thus obtained are durable and can be used for both intramuscular and intravenous use will. -
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV1853D DE871496C (en) | 1944-10-03 | 1944-10-03 | Process for the preservation of concentrated solutions of p-aminobenzene sulfonamide or its decoctions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV1853D DE871496C (en) | 1944-10-03 | 1944-10-03 | Process for the preservation of concentrated solutions of p-aminobenzene sulfonamide or its decoctions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE871496C true DE871496C (en) | 1953-03-23 |
Family
ID=7569830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEV1853D Expired DE871496C (en) | 1944-10-03 | 1944-10-03 | Process for the preservation of concentrated solutions of p-aminobenzene sulfonamide or its decoctions |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE871496C (en) |
-
1944
- 1944-10-03 DE DEV1853D patent/DE871496C/en not_active Expired
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