DE836079C - Process for the production of durable solutions from sulfonamides and hexamethylenetetramine - Google Patents

Process for the production of durable solutions from sulfonamides and hexamethylenetetramine

Info

Publication number
DE836079C
DE836079C DEV2329A DEV0002329A DE836079C DE 836079 C DE836079 C DE 836079C DE V2329 A DEV2329 A DE V2329A DE V0002329 A DEV0002329 A DE V0002329A DE 836079 C DE836079 C DE 836079C
Authority
DE
Germany
Prior art keywords
sulfonamides
hexamethylenetetramine
production
durable solutions
durable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEV2329A
Other languages
German (de)
Inventor
Dr Werner Ursum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INH APOTH E RATH
Vial & Uhlmann
Original Assignee
INH APOTH E RATH
Vial & Uhlmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INH APOTH E RATH, Vial & Uhlmann filed Critical INH APOTH E RATH
Priority to DEV2329A priority Critical patent/DE836079C/en
Application granted granted Critical
Publication of DE836079C publication Critical patent/DE836079C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung haltbarer Lösungen aus Sulfonamiden und Hexamethylentetramin Es wurde gefunden, daß man zu therapeutisch äußerst wirksamen Verbindungen aus Sulfonamiden und Hexamethylentetramin dadurch gelangen kann, daß man ein oder mehrere Sulfonamide bzw. deren Salze einesteils und Hexamethylentetramin andernteils in Wasser zusammengibt, wobei zunächst schwer lösliche Verbindungen entstehen; die schwer löslichen Zwischenverbindungen werden längere Zeit und wiederholt erhitzt, wobei die Schiffschen Basen in @ (isung gehen und aus den schwer löslichen Bestandteilen sich haltbare und leicht lösliche Verbindungen bilden. Unter wiederholtem Erhitzen im Sinne der Erfindung ist ein unterbrochenes Erhitzen zu verstehen, z. B. in der Weise, daß der Ansatz auf Temperaturen zwischen etwa 60 und 100° gebracht wird, was auf dem Wasserbad geschehen kann, und die Erhitzung mehrere Stunden im angegebenen Temperaturbereich vorgenommen wird, worauf der Ansatz abgekühlt oder stehengelassen und dann der Erhitzungsvorgang in Zeitabständen von etwa einem Tag wiederholt wird.Process for making durable solutions from sulfonamides and Hexamethylenetetramine It has been found to be extremely effective therapeutically Compounds of sulfonamides and hexamethylenetetramine can get through that one or more sulfonamides or their salts on the one hand and hexamethylenetetramine on the other hand merges in water, initially with poorly soluble compounds develop; the poorly soluble intermediate compounds are repeated for a long time heated, whereby the Schiff bases go into @ (isung and from the poorly soluble Constituents form durable and easily soluble compounds. Under repeated Heating in the context of the invention is to be understood as an interrupted heating, z. B. in such a way that the approach is brought to temperatures between about 60 and 100 ° what can be done on the water bath, and heating for several hours in the specified temperature range is made, whereupon the batch cooled or left to stand and then the heating process at intervals of about one day is repeated.

B e i s p i e l 1400 g Hexamethylentetramin werden mit 400 g sulfosalicylsaurem p-Aminobenzolsulfonamid in Gegenwart von 7 1 Wasser auf 90° erhitzt. Es entsteht allmählich eine klare Lösung, die an den darauffolgenden heiden Tagen je 3 Stunden auf diesell>e Temperatur erhitzt wird. Die gewonnene lösung ist von klarer Beschaffenheit und hat sich als äußerst wirksam, insbesondere gegen Coliinfektionen erwiesen. Sie kann auch intravenös appliziert werden. For example, 1400 g of hexamethylenetetramine are mixed with 400 g sulfosalicylic acid p-Aminobenzenesulfonamide heated to 90 ° in the presence of 7 l of water. It arises gradually a clear solution, which on the following two days each 3 hours heated to diesel temperature. The solution obtained is clear in nature and has been shown to be extremely effective, especially against coliform infections. she can also be administered intravenously.

Claims (1)

P A T E N T A N S P R U C H . P A T E N T A N S P R U C H. Verfahren zur Herstellung haltbarer Lösungen aus Sulfonamiden und Hexamethylentetram.in, dadurch gekennzeichnet, daß ein oder mehrere Sulfonamide bzw. deren Salze einesteils und Hexamethylentetramin anderntejls in Wasser zusammengebracht und der Ansatz swiederholt und längere Zeit erhitzt wird. Process for making durable solutions from sulfonamides and Hexamethylenetetram.in, characterized in that one or more sulfonamides or their salts, on the one hand, and hexamethylenetetramine, on the other, brought together in water and the approach is repeated and heated for a long time.
DEV2329A 1950-09-17 1950-09-17 Process for the production of durable solutions from sulfonamides and hexamethylenetetramine Expired DE836079C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEV2329A DE836079C (en) 1950-09-17 1950-09-17 Process for the production of durable solutions from sulfonamides and hexamethylenetetramine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEV2329A DE836079C (en) 1950-09-17 1950-09-17 Process for the production of durable solutions from sulfonamides and hexamethylenetetramine

Publications (1)

Publication Number Publication Date
DE836079C true DE836079C (en) 1952-04-07

Family

ID=7570065

Family Applications (1)

Application Number Title Priority Date Filing Date
DEV2329A Expired DE836079C (en) 1950-09-17 1950-09-17 Process for the production of durable solutions from sulfonamides and hexamethylenetetramine

Country Status (1)

Country Link
DE (1) DE836079C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1056136B (en) * 1956-12-21 1959-04-30 Bayer Ag Process for the preparation of a molecular compound from p-aminobenzenesulfonylthiourea (sulfathiourea) and hexamethylenetetramine
EP0037501A1 (en) * 1980-03-25 1981-10-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pharmaceutical preparations and manufacature

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1056136B (en) * 1956-12-21 1959-04-30 Bayer Ag Process for the preparation of a molecular compound from p-aminobenzenesulfonylthiourea (sulfathiourea) and hexamethylenetetramine
EP0037501A1 (en) * 1980-03-25 1981-10-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pharmaceutical preparations and manufacature

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