DE377588C - Process for the preparation of a salt-like compound of codeine - Google Patents

Process for the preparation of a salt-like compound of codeine

Info

Publication number
DE377588C
DE377588C DEH91030D DEH0091030D DE377588C DE 377588 C DE377588 C DE 377588C DE H91030 D DEH91030 D DE H91030D DE H0091030 D DEH0091030 D DE H0091030D DE 377588 C DE377588 C DE 377588C
Authority
DE
Germany
Prior art keywords
compound
codeine
salt
preparation
codeire
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEH91030D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
O HINSBERG DR
Original Assignee
O HINSBERG DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by O HINSBERG DR filed Critical O HINSBERG DR
Priority to DEH91030D priority Critical patent/DE377588C/en
Application granted granted Critical
Publication of DE377588C publication Critical patent/DE377588C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Darstellung einer salzartigen Verbindung des Codeins. Verbindungen des Codeins mit Phenolen sind bisher nicht bekannt und scheinen auch im allgemeinen nicht existenzfähig zu sein. Eine Ausnahme macht, wie gefunden wurde, das p-Acetamidophenol, welches sich mit Codeire in wässeriger oder alkoholischer Lösung zu einer gut charakterisierten Verbindung vereinigt. Sie hat die Zusammensetzung: Codeire (z Mol.) -f- p-Acetamidophenol (r Mol.) - C1$ H2103 N + CG H4 (O H) # (N H - C O C H3) . Beispiel.Process for the preparation of a salt-like compound of codeine. Compounds of codeine with phenols are not yet known and also appear to be generally not being able to exist. An exception is made, as was found, the p-acetamidophenol, which is associated with Codeire in aqueous or alcoholic Solution combined into a well-characterized compound. It has the composition: Codeire (z Mol.) -F- p-Acetamidophenol (r Mol.) - C1 $ H2103 N + CG H4 (O H) # (N H - C O C H3). Example.

r Gewichtsteil Codeire wird gemeinsam Mit o,52 Teilen p-Acetamidophenol in verdünntem Alkohol aufgelöst. Beim Verdunsten der Lösung scheidet sich das Additionprodukt zunächst ölig aus. Es wird nach dem Abgießen der Mutterlaugen und Verweilen im Exsikkator fest und kann durch Umlösen aus heißem Wasser gereinigt werden. Die im Exsikkator getrocknete Verbindung schmilzt unter vorheriger Sinterung bei 1250. Die Zusammensetzung t Codeire -E- z p-Acetamidophenol geht daraus hervor, daß bei Anwendung von mehr als r Mol.-Gew. p-Acetamidophenol auf z Mol. Codeire ersteres aus der Lösung zum Teil unverändert auskristallisiert.r part by weight of Codeire is combined with 0.52 parts of p-acetamidophenol dissolved in diluted alcohol. When the solution evaporates, the addition product separates initially oily. It becomes after the mother liquors have been poured off and left in the desiccator solid and can be cleaned by dissolving in hot water. The one in the desiccator dried compound melts with prior sintering at 1250. The composition t Codeire -E- z p-Acetamidophenol shows that when using more as r mol. wt. p-Acetamidophenol to z mol. Codeire the former from the solution to Part crystallized out unchanged.

Die Verbindung soll therapeutische Verwendung finden.The compound is intended to find therapeutic use.

Claims (1)

PATENT-ANSPRUcH: Verfahren zur Darstellung einer salzartigen Verbindung des Codeins, dadurch gekennzeichnet, daß äquivalente Mengen Codeire und p-Acetamidophenol mit oder ohne Lösungsmittel zusammengebracht werden.PATENT CLAIM: Process for the preparation of a salt-like compound of codeine, characterized in that equivalent amounts of codeire and p-acetamidophenol be brought together with or without a solvent.
DEH91030D 1922-08-29 1922-08-29 Process for the preparation of a salt-like compound of codeine Expired DE377588C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEH91030D DE377588C (en) 1922-08-29 1922-08-29 Process for the preparation of a salt-like compound of codeine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEH91030D DE377588C (en) 1922-08-29 1922-08-29 Process for the preparation of a salt-like compound of codeine

Publications (1)

Publication Number Publication Date
DE377588C true DE377588C (en) 1923-06-22

Family

ID=7166055

Family Applications (1)

Application Number Title Priority Date Filing Date
DEH91030D Expired DE377588C (en) 1922-08-29 1922-08-29 Process for the preparation of a salt-like compound of codeine

Country Status (1)

Country Link
DE (1) DE377588C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190947A (en) * 1990-08-23 1993-03-02 Ciba-Geigy Corporation Codeine salt of a substituted carboxylic acid, its use and pharmaceutical compositions thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190947A (en) * 1990-08-23 1993-03-02 Ciba-Geigy Corporation Codeine salt of a substituted carboxylic acid, its use and pharmaceutical compositions thereof

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