DE60336018D1 - Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren - Google Patents
Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahrenInfo
- Publication number
- DE60336018D1 DE60336018D1 DE60336018T DE60336018T DE60336018D1 DE 60336018 D1 DE60336018 D1 DE 60336018D1 DE 60336018 T DE60336018 T DE 60336018T DE 60336018 T DE60336018 T DE 60336018T DE 60336018 D1 DE60336018 D1 DE 60336018D1
- Authority
- DE
- Germany
- Prior art keywords
- hypertensive
- manufacturing process
- peg chains
- reacting
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001554 Hemoglobins Human genes 0.000 title abstract 3
- 108010054147 Hemoglobins Proteins 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 title 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43614902P | 2002-12-23 | 2002-12-23 | |
| PCT/US2003/040407 WO2004058291A1 (en) | 2002-12-23 | 2003-12-18 | Modified hemoglobin and methods of making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60336018D1 true DE60336018D1 (de) | 2011-03-24 |
Family
ID=32682349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336018T Expired - Lifetime DE60336018D1 (de) | 2002-12-23 | 2003-12-18 | Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7501499B2 (de) |
| EP (1) | EP1585538B1 (de) |
| JP (1) | JP2006514652A (de) |
| KR (1) | KR101086138B1 (de) |
| CN (1) | CN1741812B (de) |
| AT (1) | ATE497776T1 (de) |
| AU (1) | AU2003299700B2 (de) |
| BR (1) | BR0317721A (de) |
| CA (1) | CA2511494A1 (de) |
| DE (1) | DE60336018D1 (de) |
| ES (1) | ES2360215T3 (de) |
| MX (1) | MXPA05006702A (de) |
| MY (1) | MY135256A (de) |
| SA (1) | SA04250032B1 (de) |
| TW (1) | TW200505941A (de) |
| WO (1) | WO2004058291A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1465643T1 (sl) * | 2002-01-11 | 2008-06-30 | Sangart Inc | Postopki in sestavki za transport kisika z visokoafiniteto za kisik |
| US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US7144989B2 (en) | 2002-03-25 | 2006-12-05 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
| US7521174B2 (en) * | 2003-12-05 | 2009-04-21 | Albert Einstein College Of Medicine Of Yeshiva University | Universal red blood cells, methods of preparing same, and uses thereof |
| AU2005279780B2 (en) * | 2004-08-31 | 2011-02-03 | Sangart, Inc. | Methods to enhance hemodynamic stability using oxygen carrying compositions |
| US20060134694A1 (en) * | 2004-12-22 | 2006-06-22 | Intel Corporation | Methods of protein profiling by thiolation |
| WO2006096774A2 (en) | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
| WO2007050121A2 (en) * | 2005-05-11 | 2007-05-03 | Albert Einstein College Of Medicine Of Yeshiva University | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
| WO2007058678A2 (en) | 2005-06-10 | 2007-05-24 | Albert Einstein College Of Medicine Of Yeshiva University | Uses of pegylated albumin |
| WO2006135740A1 (en) * | 2005-06-10 | 2006-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated hemoglobin and albumin and uses thereof |
| US7795401B2 (en) * | 2006-09-06 | 2010-09-14 | National Chung Cheng University | Modified hemoglobin with allosteric effector conjugated |
| US8697645B2 (en) * | 2007-03-13 | 2014-04-15 | Albert Einstein College Of Medicine Of Yeshiva University | Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders |
| CN101306196B (zh) * | 2008-07-03 | 2011-05-11 | 中国科学院长春应用化学研究所 | 一种生物降解的键合了血红蛋白分子的纳米粒子及制法 |
| US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| NZ597022A (en) | 2009-06-09 | 2014-05-30 | Prolong Pharmaceuticals Llc | Hemoglobin compositions |
| US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| CA2791122C (en) * | 2010-02-25 | 2019-08-27 | Sangart, Inc. | Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios |
| US7989593B1 (en) | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US8048856B1 (en) | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
| US7932356B1 (en) | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
| US8084581B1 (en) | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
| US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
| CN104379160A (zh) | 2012-03-29 | 2015-02-25 | 桑加特公司 | 双阿司匹林交联聚乙二醇化血红蛋白 |
| KR102076874B1 (ko) | 2012-04-03 | 2020-02-12 | 쉰들러, 윌리엄 | 숙신이미드-활성화 나이트록실 화합물 및 단백질의 나이트록실화를 위한 이의 사용 방법 |
| CN105188761B (zh) * | 2013-03-15 | 2020-05-15 | 桑加特公司 | 聚环氧烷戊酸酯血红蛋白缀合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US5900402A (en) * | 1997-05-29 | 1999-05-04 | Enzon, Inc. | Method of reducing side effects associated with administration of oxygen-carrying proteins |
| US6773613B1 (en) | 1998-10-15 | 2004-08-10 | Sangart, Inc. | Method for production of stroma-free hemoglobin |
| US7019117B2 (en) | 2001-07-19 | 2006-03-28 | Albert Einstein College Of Medicine Of Yeshiva University | Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| WO2003059286A2 (en) | 2002-01-11 | 2003-07-24 | Sangart, Inc. | Methods and compositions for oxygen transport comprising modified hemoglobin in plasma |
| US7144989B2 (en) | 2002-03-25 | 2006-12-05 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
| US7521174B2 (en) | 2003-12-05 | 2009-04-21 | Albert Einstein College Of Medicine Of Yeshiva University | Universal red blood cells, methods of preparing same, and uses thereof |
| WO2007050121A2 (en) | 2005-05-11 | 2007-05-03 | Albert Einstein College Of Medicine Of Yeshiva University | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
-
2003
- 2003-12-18 MX MXPA05006702A patent/MXPA05006702A/es active IP Right Grant
- 2003-12-18 JP JP2004563778A patent/JP2006514652A/ja active Pending
- 2003-12-18 CA CA002511494A patent/CA2511494A1/en not_active Abandoned
- 2003-12-18 EP EP03799982A patent/EP1585538B1/de not_active Expired - Lifetime
- 2003-12-18 KR KR1020057011737A patent/KR101086138B1/ko not_active IP Right Cessation
- 2003-12-18 DE DE60336018T patent/DE60336018D1/de not_active Expired - Lifetime
- 2003-12-18 AU AU2003299700A patent/AU2003299700B2/en not_active Ceased
- 2003-12-18 US US10/538,976 patent/US7501499B2/en not_active Expired - Fee Related
- 2003-12-18 AT AT03799982T patent/ATE497776T1/de not_active IP Right Cessation
- 2003-12-18 BR BR0317721-1A patent/BR0317721A/pt not_active IP Right Cessation
- 2003-12-18 WO PCT/US2003/040407 patent/WO2004058291A1/en active Application Filing
- 2003-12-18 ES ES03799982T patent/ES2360215T3/es not_active Expired - Lifetime
- 2003-12-18 CN CN2003801091578A patent/CN1741812B/zh not_active Expired - Fee Related
- 2003-12-22 MY MYPI20034947A patent/MY135256A/en unknown
- 2003-12-23 TW TW092136572A patent/TW200505941A/zh unknown
-
2004
- 2004-03-09 SA SA04250032A patent/SA04250032B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1585538A4 (de) | 2007-11-21 |
| ES2360215T3 (es) | 2011-06-01 |
| BR0317721A (pt) | 2005-12-06 |
| CA2511494A1 (en) | 2004-07-15 |
| SA04250032B1 (ar) | 2007-07-31 |
| MXPA05006702A (es) | 2005-09-30 |
| TW200505941A (en) | 2005-02-16 |
| EP1585538A1 (de) | 2005-10-19 |
| AU2003299700B2 (en) | 2009-03-26 |
| US7501499B2 (en) | 2009-03-10 |
| CN1741812B (zh) | 2013-04-24 |
| ATE497776T1 (de) | 2011-02-15 |
| EP1585538B1 (de) | 2011-02-09 |
| WO2004058291A1 (en) | 2004-07-15 |
| US20060135753A1 (en) | 2006-06-22 |
| MY135256A (en) | 2008-03-31 |
| KR20050084460A (ko) | 2005-08-26 |
| AU2003299700A1 (en) | 2004-07-22 |
| JP2006514652A (ja) | 2006-05-11 |
| CN1741812A (zh) | 2006-03-01 |
| KR101086138B1 (ko) | 2011-11-25 |
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