DE60335608D1 - Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung - Google Patents
Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendungInfo
- Publication number
- DE60335608D1 DE60335608D1 DE60335608T DE60335608T DE60335608D1 DE 60335608 D1 DE60335608 D1 DE 60335608D1 DE 60335608 T DE60335608 T DE 60335608T DE 60335608 T DE60335608 T DE 60335608T DE 60335608 D1 DE60335608 D1 DE 60335608D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- therapeutics
- delivery
- materials
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36035002P | 2002-02-27 | 2002-02-27 | |
| PCT/US2003/005937 WO2003072143A1 (en) | 2002-02-27 | 2003-02-27 | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60335608D1 true DE60335608D1 (de) | 2011-02-17 |
Family
ID=27766225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60335608T Expired - Lifetime DE60335608D1 (de) | 2002-02-27 | 2003-02-27 | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7138105B2 (https=) |
| EP (1) | EP1478406B1 (https=) |
| JP (1) | JP2005524657A (https=) |
| AT (1) | ATE494010T1 (https=) |
| AU (1) | AU2003219922B2 (https=) |
| CA (1) | CA2476589C (https=) |
| DE (1) | DE60335608D1 (https=) |
| WO (1) | WO2003072143A1 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| CA2480408A1 (en) * | 2002-02-26 | 2003-09-04 | Masahiro Murakami | A method for encapsulating metal complex in liposomes |
| US20100069293A1 (en) * | 2002-02-27 | 2010-03-18 | Pharmain Corporation | Polymeric carrier compositions for delivery of active agents, methods of making and using the same |
| US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| DE60335608D1 (de) | 2002-02-27 | 2011-02-17 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
| US7629049B2 (en) * | 2002-10-18 | 2009-12-08 | Medasorb, Inc. | Hemocompatible polymer systems and related devices |
| WO2005010080A1 (ja) * | 2003-07-28 | 2005-02-03 | Teijin Limited | 温度応答性ハイドロゲル |
| US20060246137A1 (en) * | 2003-07-30 | 2006-11-02 | Laurence Hermitte | Complex matrix for biomedical use |
| ATE365034T1 (de) * | 2003-09-10 | 2007-07-15 | Cristalia Prod Quimicos Farm | Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether- verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindung |
| EA018643B1 (ru) * | 2004-02-23 | 2013-09-30 | Цайтэн Чжан | Раствор металлсодержащего хелатного полимера и его применение (варианты) |
| JP2007527431A (ja) * | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| BRPI0508410B8 (pt) * | 2004-03-03 | 2021-05-25 | Revance Therapeutics Inc | composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas |
| WO2005112977A2 (en) * | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| BRPI0404983A (pt) * | 2004-09-03 | 2006-05-02 | Nanocore Biotecnologia Ltda | composições imunogênicas |
| AU2006204045B2 (en) * | 2005-01-05 | 2010-10-14 | Board Of Regents, The University Of Texas System | Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| US20090291508A1 (en) * | 2008-05-20 | 2009-11-26 | Rapid Pathogen Screening Inc. | Nanoparticles in diagnostic tests |
| ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| EP1841471B1 (de) * | 2005-09-09 | 2010-07-28 | Aesculap AG | Antimikrobielles medizintechnisches produkt, verfahren zu seiner herstellung und verwendung |
| JP4670583B2 (ja) * | 2005-10-20 | 2011-04-13 | チッソ株式会社 | 水溶性カチオン性磁気微粒子を用いた脂質ベシクルの分離又は検出方法 |
| ES2548240T3 (es) | 2005-12-01 | 2015-10-15 | Pronai Therapeutics, Inc. | Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas |
| KR101529318B1 (ko) * | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| EP2359808B1 (en) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Osmotic delivery systems and piston assemblies |
| US9604196B2 (en) | 2006-11-20 | 2017-03-28 | Cytosorbent, Inc. | Size-selective hemocompatible polymer system |
| WO2008064311A2 (en) * | 2006-11-21 | 2008-05-29 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
| US20100004124A1 (en) * | 2006-12-05 | 2010-01-07 | David Taft | Systems and methods for delivery of materials for agriculture and aquaculture |
| EP2500015A1 (en) * | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
| US20090263346A1 (en) * | 2006-12-05 | 2009-10-22 | David Taft | Systems and methods for delivery of drugs |
| US8399007B2 (en) * | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
| US20090246155A1 (en) * | 2006-12-05 | 2009-10-01 | Landec Corporation | Compositions and methods for personal care |
| WO2008128058A1 (en) * | 2007-04-13 | 2008-10-23 | The Trustees Of The University Of Pennsylvania | New gallium bisaminothiolate complexes for myocardial imaging |
| WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| WO2009079066A2 (en) * | 2007-09-26 | 2009-06-25 | Aparna Biosciences | Therapeutic and vaccine polyelectrolyte nanoparticle compositions |
| US8114883B2 (en) * | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
| US20090176892A1 (en) | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| WO2009114520A2 (en) * | 2008-03-10 | 2009-09-17 | Pharmain Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
| SI2341905T2 (sl) * | 2008-09-04 | 2024-02-29 | Amylin Pharmaceuticals, Llc | Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev |
| JP5820378B2 (ja) | 2009-09-09 | 2015-11-24 | ファーマイン コーポレーションPharmain Corporation | 治療剤の送達のための陰イオンコア組成物およびその製造ならびに使用方法 |
| RU2547990C2 (ru) | 2009-09-28 | 2015-04-10 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| DK2343051T3 (da) | 2010-01-05 | 2014-10-27 | Nat Univ Dong Hwa | Anti-cancer formulering |
| EP2538956A4 (en) * | 2010-02-22 | 2015-04-22 | Edge Therapeutics Inc | METHODS AND COMPOSITIONS FOR TREATING HEMORRHAGIC BRAIN DISORDERS |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| RU2606169C2 (ru) | 2011-04-05 | 2017-01-10 | Эдж Терапьютикс | Система интравентрикулярной доставки лекарственного средства для улучшения исхода после повреждения головного мозга, нарушающего мозговое кровообращение |
| US8785569B2 (en) * | 2011-11-22 | 2014-07-22 | Original Biomedicals Co., Ltd. | Drug carrier with chelating complex micelles and the application thereof |
| CA2890725A1 (en) | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| MX380982B (es) | 2014-09-24 | 2025-03-12 | Colgate Palmolive Co | Biodisponibilidad de iones de metal. |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| RU2730996C2 (ru) | 2015-06-03 | 2020-08-26 | Интарсия Терапьютикс, Инк. | Системы установки и извлечения имплантата |
| CN105054074A (zh) * | 2015-07-01 | 2015-11-18 | 浙江海洋学院 | 一种鱼糜酶解肽亚铁螯合物抗氧化微胶囊及其制备工艺 |
| JP6852079B2 (ja) * | 2015-10-09 | 2021-03-31 | デベデック フランツ レ | 架橋粒子 |
| KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス,インコーポレイティド | Glp-1受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| US11905377B2 (en) | 2019-01-17 | 2024-02-20 | Pendant Biosciences, Inc. | Factors controlling drug release in cross-linked poly(valerolactone) based matrices |
| JP7691701B2 (ja) * | 2019-06-18 | 2025-06-12 | マックス-プランク-ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 金属錯体試薬を介するHisタグ付タンパク質などの標的分子への標識および/または担体の部位特異的、速度論的に不活性なコンジュゲーション |
| MX2022014143A (es) * | 2020-05-12 | 2022-11-30 | Basf Se | Uso de polimero carboximetilado de lisinas como agente dispersante y composiciones que comprenden el mismo. |
| WO2025207519A1 (en) * | 2024-03-23 | 2025-10-02 | Texas Tech University System | Biocompatible and biodegradable polymer nanodiscs as lipoprotein-mimicking nanocarriers with high stability and long circulation time for drug delivery |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5527524A (en) | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US4857311A (en) * | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US5681543A (en) | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
| US5776894A (en) | 1988-12-05 | 1998-07-07 | Novartis Ag | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors |
| US5554388A (en) | 1989-02-25 | 1996-09-10 | Danbiosyst Uk Limited | Systemic drug delivery compositions comprising a polycationi substance |
| US5744166A (en) | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| EP0610441A4 (en) | 1991-10-29 | 1996-01-10 | Clover Cons Ltd | CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS. |
| US5770563A (en) | 1991-12-06 | 1998-06-23 | The United States Of America As Represented By The Department Of Health And Human Services | Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof |
| US6113946A (en) | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| WO1993019768A1 (en) | 1992-04-03 | 1993-10-14 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system |
| DE69332952T2 (de) | 1992-09-04 | 2004-02-19 | The General Hospital Corp., Boston | Diagnostische und therapeutische Einheiten enthaltende biokompatible Polymere |
| US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| US5763585A (en) * | 1993-10-13 | 1998-06-09 | Anergen, Inc. | Method of making MHC-peptide complexes using metal chelate affinity chromatography |
| IL112920A (en) | 1994-03-07 | 2003-04-10 | Dow Chemical Co | Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof |
| EP0804249A2 (en) | 1994-03-15 | 1997-11-05 | Brown University Research Foundation | Polymeric gene delivery system |
| US5466467A (en) * | 1994-03-30 | 1995-11-14 | The United States Of America As Represented By The Secretary Of The Navy | Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes |
| GB9409496D0 (en) | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| US20010006943A1 (en) | 1994-12-23 | 2001-07-05 | Ejvind Jensen | Protracted GLP-1 compositions |
| US5834428A (en) | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US5929031A (en) | 1995-05-02 | 1999-07-27 | Baxter Biotech Technology Sarl | Storage stable hemoglobin solutions |
| US5855610A (en) * | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| CA2224253A1 (en) * | 1995-06-09 | 1996-12-27 | Martin J. Macphee | Chitin hydrogels, methods of their production and use |
| MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
| US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| WO1997014740A1 (en) * | 1995-10-19 | 1997-04-24 | Receptagen Corporation | Discrete-length polyethylene glycols |
| CN1304058C (zh) | 1996-03-12 | 2007-03-14 | Pg-Txl有限公司 | 水溶性紫杉醇产品 |
| US6254854B1 (en) * | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| JPH10158195A (ja) | 1996-11-28 | 1998-06-16 | Res Inst For Prod Dev | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| GEP20022707B (en) | 1997-07-18 | 2002-06-25 | Infimed Inc Us | Biodegrading Macromers for the Controlled Release of Biologically Active Substances |
| DE19740069A1 (de) * | 1997-09-12 | 1999-03-18 | Clariant Gmbh | Mischungen von langkettigen Phosphorsäurealkylestern |
| US6468532B1 (en) | 1998-01-22 | 2002-10-22 | Genentech, Inc. | Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| US6509323B1 (en) * | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| DE69941510D1 (de) | 1998-08-10 | 2009-11-19 | Us Gov Nat Inst Health | Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung |
| IL140892A0 (en) * | 1998-08-12 | 2002-02-10 | Yissum Res Dev Co | Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| JP2002534363A (ja) * | 1999-01-08 | 2002-10-15 | エミスフェアー・テクノロジーズ・インク | ポリマー性デリバリー剤及びデリバリー剤化合物 |
| US6365173B1 (en) | 1999-01-14 | 2002-04-02 | Efrat Biopolymers Ltd. | Stereocomplex polymeric carriers for drug delivery |
| US6395299B1 (en) * | 1999-02-12 | 2002-05-28 | Biostream, Inc. | Matrices for drug delivery and methods for making and using the same |
| DE60041255D1 (de) | 1999-04-28 | 2009-02-12 | Eidgenoess Tech Hochschule | Polyionische beschichtungen für analytische und sensor-vorrichtungen |
| AU1087701A (en) | 1999-10-15 | 2001-04-30 | Canji, Inc. | Targeted vectors |
| US6569832B1 (en) | 1999-11-12 | 2003-05-27 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
| US6593308B2 (en) * | 1999-12-03 | 2003-07-15 | The Regents Of The University Of California | Targeted drug delivery with a hyaluronan ligand |
| CN1487836A (zh) | 2000-03-14 | 2004-04-07 | 埃米林药品公司 | 胰高糖素样肽1(7-36)对胃窦幽门十二指肠能动性的影响 |
| US6998137B2 (en) | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| US6589549B2 (en) | 2000-04-27 | 2003-07-08 | Macromed, Incorporated | Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles |
| IL152804A0 (en) | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| CN103356996A (zh) | 2000-05-19 | 2013-10-23 | 埃米林药品公司 | Glp-1用于制备治疗急性冠脉综合征的药物的用途 |
| US6338859B1 (en) * | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
| JP5610659B2 (ja) | 2000-07-21 | 2014-10-22 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 多成分生物学的輸送システム |
| US20040092432A1 (en) | 2000-08-24 | 2004-05-13 | Thomas Jefferson University | Peptide compositions with effects on cerebral health |
| US6521736B2 (en) * | 2000-09-15 | 2003-02-18 | University Of Massachusetts | Amphiphilic polymeric materials |
| NZ519752A (en) | 2000-10-20 | 2005-04-29 | Amylin Pharmaceuticals Inc | Treatment of hibernating myocardium and diabetic cardiomyopathy with a GLP-1 peptide |
| US20020132254A1 (en) * | 2000-11-30 | 2002-09-19 | Twu Jesse J. | Molecular labeling and assay systems using poly (amino acid)-metal ion complexes as linkers |
| AU2002228608A1 (en) | 2000-12-13 | 2002-06-24 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| AU3938402A (en) | 2000-12-13 | 2002-06-24 | Lilly Co Eli | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| ITMI20011057A1 (it) | 2001-05-22 | 2002-11-22 | Bracco Imaging Spa | Preparazione ed uso di peptidi ciclici e ramificati e loro deriati marcati come agenti terapeutici agonisti o antagonisti della colecistochi |
| AU2002308706A1 (en) | 2001-06-01 | 2002-12-16 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| WO2003002136A2 (en) | 2001-06-28 | 2003-01-09 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| AU2002322403A1 (en) | 2001-08-23 | 2003-03-10 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| CN1561224A (zh) | 2001-10-01 | 2005-01-05 | 伊莱利利公司 | 降低与严重疾病相关的死亡率和发病率的方法 |
| US7041646B2 (en) | 2001-10-05 | 2006-05-09 | Bayer Pharmaceuticals Corporation | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists |
| KR20040058324A (ko) | 2001-11-26 | 2004-07-03 | 다이이찌 산토리 파마 가부시키가이샤 | 경비흡수용 의약 조성물 |
| PL209734B1 (pl) | 2002-02-20 | 2011-10-31 | Emisphere Tech Inc | Preparat farmaceutyczny zawierający związek GLP-1 i czynnik dostarczający oraz jego zastosowanie |
| DE60335608D1 (de) | 2002-02-27 | 2011-02-17 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
| US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| WO2004005342A1 (en) | 2002-07-04 | 2004-01-15 | Zealand Pharma A/S | Glp-1 and methods for treating diabetes |
| JP2006501820A (ja) | 2002-09-06 | 2006-01-19 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 修飾glp−1受容体アゴニストおよびそれらの薬理学的使用法 |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US20040209803A1 (en) | 2002-12-19 | 2004-10-21 | Alain Baron | Compositions for the treatment and prevention of nephropathy |
| CN1767815A (zh) | 2003-03-31 | 2006-05-03 | 阿尔萨公司 | 非水单相载体和使用这类载体的制剂 |
| EP1631308B1 (en) | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| KR101308912B1 (ko) | 2003-06-03 | 2013-09-23 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
| ES2375056T3 (es) | 2003-06-03 | 2012-02-24 | Novo Nordisk A/S | Composiciones pept�?dicas farmacéuticas estabilizadas. |
| US20060247167A1 (en) | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| EP1694278A4 (en) | 2003-12-16 | 2009-08-12 | Ipsen Pharma | GLP-1 PHARMACEUTICAL COMPOSITIONS |
| US8372966B2 (en) | 2003-12-19 | 2013-02-12 | University Of Cincinnati | Oligonucleotide decoys and methods of use |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US20050143303A1 (en) | 2003-12-26 | 2005-06-30 | Nastech Pharmaceutical Company Inc. | Intranasal administration of glucose-regulating peptides |
| US20060074025A1 (en) | 2003-12-26 | 2006-04-06 | Nastech Pharmaceutical Company Inc. | Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability |
| JP2007527431A (ja) | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| FR2867679B1 (fr) | 2004-03-17 | 2008-08-22 | Oreal | Composition cosmetiques comprenant des polyamines modifiees et utilisations desdites compositions. |
| US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| ES2547220T3 (es) | 2004-04-20 | 2015-10-02 | Dendritic Nanotechnologies, Inc. | Polímeros dendríticos con amplificación y funcionalidad interior mejoradas |
| WO2005112977A2 (en) | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| WO2006080951A2 (en) | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
| WO2006014425A1 (en) | 2004-07-02 | 2006-02-09 | Biovalve Technologies, Inc. | Methods and devices for delivering glp-1 and uses thereof |
| RU2527893C2 (ru) | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| US7285529B2 (en) | 2005-02-28 | 2007-10-23 | Gene Tools, Llc | Embedder compositions and methods for detecting and killing cells in acidic areas of tumors |
| US20090202497A1 (en) | 2005-08-23 | 2009-08-13 | The General Hospital Corporation | Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes |
| WO2007030706A1 (en) | 2005-09-08 | 2007-03-15 | New England Medical Center Hospitals, Inc. | Fragments of the glucagon-like peptide-i and uses thereof |
| ES2625109T3 (es) | 2005-10-25 | 2017-07-18 | Starpharma Pty Limited | Compuestos macromoleculares que tienen estequiometría controlada |
| US8202837B2 (en) | 2005-11-04 | 2012-06-19 | Glaxosmithkline Llc | Methods for administering hypoglycemic agents |
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| JP5989294B2 (ja) | 2006-01-20 | 2016-09-07 | スターファーマ・プロプライエタリー・リミテッドStarpharma Pty Ltd | 修飾高分子 |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
-
2003
- 2003-02-27 DE DE60335608T patent/DE60335608D1/de not_active Expired - Lifetime
- 2003-02-27 EP EP03716207A patent/EP1478406B1/en not_active Expired - Lifetime
- 2003-02-27 WO PCT/US2003/005937 patent/WO2003072143A1/en not_active Ceased
- 2003-02-27 US US10/378,100 patent/US7138105B2/en not_active Expired - Lifetime
- 2003-02-27 AT AT03716207T patent/ATE494010T1/de not_active IP Right Cessation
- 2003-02-27 AU AU2003219922A patent/AU2003219922B2/en not_active Expired
- 2003-02-27 JP JP2003570887A patent/JP2005524657A/ja active Pending
- 2003-02-27 CA CA2476589A patent/CA2476589C/en not_active Expired - Lifetime
-
2006
- 2006-07-05 US US11/428,803 patent/US7790140B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2476589C (en) | 2014-02-25 |
| US20030224974A1 (en) | 2003-12-04 |
| WO2003072143A1 (en) | 2003-09-04 |
| AU2003219922A1 (en) | 2003-09-09 |
| EP1478406B1 (en) | 2011-01-05 |
| EP1478406A1 (en) | 2004-11-24 |
| EP1478406A4 (en) | 2006-01-11 |
| US20060239924A1 (en) | 2006-10-26 |
| US7790140B2 (en) | 2010-09-07 |
| JP2005524657A (ja) | 2005-08-18 |
| WO2003072143A9 (en) | 2004-03-04 |
| CA2476589A1 (en) | 2003-09-04 |
| US7138105B2 (en) | 2006-11-21 |
| AU2003219922B2 (en) | 2009-09-10 |
| ATE494010T1 (de) | 2011-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60335608D1 (de) | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung | |
| DE60021729D1 (de) | Photosensibilisatoren enthaltende antimikrobielle zusammensetzung, gegenstände und verfahren zur verwendung | |
| DE60043229D1 (de) | Zusammensetzung zur gefässbeschichtung | |
| ATE547101T1 (de) | Verfahren zur verwendung von diketopiperazinen und zusammensetzungen, die diese enthalten | |
| DE602004031134D1 (de) | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa | |
| DE60314865D1 (de) | Verfahren zur herstellung von modifiziertem polymer, danach erhaltenes modifiziertes polymer und kautschukzusammensetzung | |
| ATE520781T1 (de) | Verfahren zur veränderung des gehalts von speicherstoffen in pflanzen | |
| ATE537826T1 (de) | Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung | |
| ATE233762T1 (de) | Bicyclische polyamiosaure metallkomplexe, verfahren zu ihrer herstellung und ihre verwendung für medizinische bilderzeugung | |
| DE60143635D1 (de) | Blockpolymer, Verfahren zur Herstellung von Polymer und Festpolymerelektrolytbrennstoffzelle | |
| DE602004012796D1 (de) | Dichtungsprofil, Verfahren zu seiner Herstellung und Formwerkzeug zur Verwendung in diesem Verfahren | |
| DE69939475D1 (de) | Blockpolymerzusammensetzung, verfahren zu dessen herstellung und druckempfindliche klebstoffzusammensetzung | |
| DE60218524D1 (de) | Verfahren zur herstellung von wasserlöslichen methacrylpolymeren, wasserlösliche methacrylpolymere und deren verwendung | |
| GB0307834D0 (en) | Composition | |
| UA88463C2 (ru) | Фармацевтическая композиция, которая содержит соединение 1, и процесс лечения вич-инфекции | |
| PL1654253T3 (pl) | Podstawione pochodne 3-pirolidynoindolu | |
| DE60206931D1 (de) | Polyetherpolymer, verfahren zu seiner herstellung, zusammensetzung für polymerfestelektrolyt und verwendung davon | |
| DE50101007D1 (de) | Elektrolyt und verfahren zur abscheidung von zinn-silber-legierungsschichten | |
| DE60041418D1 (de) | Zusammensetzung für hydrogele, hydrogel und dessen verwendung | |
| DE50100858D1 (de) | Verfahren zur Herstellung von Uretdionpolysocyanaten mit verbesserter Monomerenstabilität | |
| DE602004020874D1 (de) | Zusammensetzungen enthaltend hohe konzentration von kontrastmittel zur embolisierung von blutgefassen | |
| UA83203C2 (uk) | Тіазол-(бі)циклоалкілкарбоксаніліди, засіб на їх основі та застосування для боротьби з небажаними мікроорганізмами | |
| ATE480265T1 (de) | Verwendung von zahnfleischfibroblasten zur behandlung von vaskulären zellen | |
| DE50114980D1 (de) | Verfahren zur Herstellung und Verwendung von wasserlöslichen oder wasserdispergierbaren polyetherhaltigen Polymerisaten | |
| DE60028671D1 (de) | Verbesserte Polymerzusammensetzung und Verfahren zur Herstellung von Vulkanisaten damit |