ATE365034T1 - Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether- verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindung - Google Patents
Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether- verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindungInfo
- Publication number
- ATE365034T1 ATE365034T1 AT04737744T AT04737744T ATE365034T1 AT E365034 T1 ATE365034 T1 AT E365034T1 AT 04737744 T AT04737744 T AT 04737744T AT 04737744 T AT04737744 T AT 04737744T AT E365034 T1 ATE365034 T1 AT E365034T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- fluorether
- stabilizing
- degradation
- stable pharmaceutical
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000015556 catabolic process Effects 0.000 title abstract 3
- 238000006731 degradation reaction Methods 0.000 title abstract 3
- 239000003381 stabilizer Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 206010002091 Anaesthesia Diseases 0.000 title 1
- 230000037005 anaesthesia Effects 0.000 title 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 229940058015 1,3-butylene glycol Drugs 0.000 abstract 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000019437 butane-1,3-diol Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229940051250 hexylene glycol Drugs 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR0303489A BR0303489A (pt) | 2003-09-10 | 2003-09-10 | Composição farmacêutica estabilizada de composto flúor-éter e método para inibir a degradação de composto flúor-éter. uso de agente estabilizante para inibir a degradação de composto flúor éter |
| BRPI0405842A BRPI0405842B8 (pt) | 2004-07-29 | 2004-07-29 | composição farmacêutica estabilizada de composto flúor-éter para uso anestésico. método para estabilizar um composto flúor-éter. uso de agente estabilizante para impedir a degradação de composto flúor éter. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365034T1 true ATE365034T1 (de) | 2007-07-15 |
Family
ID=37450729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04737744T ATE365034T1 (de) | 2003-09-10 | 2004-08-20 | Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether- verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7816409B2 (de) |
| EP (1) | EP1663186B1 (de) |
| JP (1) | JP4253343B2 (de) |
| AT (1) | ATE365034T1 (de) |
| DE (1) | DE602004007149T2 (de) |
| ES (1) | ES2289524T3 (de) |
| HK (1) | HK1108633A1 (de) |
| MX (1) | MXPA06000803A (de) |
| PL (1) | PL1663186T3 (de) |
| PT (1) | PT1663186E (de) |
| WO (1) | WO2005023175A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06000803A (es) | 2003-09-10 | 2006-08-23 | Cristalia Prod Quimicos Farm | Composicion farmaceutica estable del compuesto de fluoroeter para uso anestesico, metodo para estabilizar un compuesto de fluoroeter, uso del agente estabilizador para evitar la degradacion de un compuesto de fluoroeter. |
| AP2007004229A0 (en) * | 2005-04-18 | 2007-12-31 | Minrad Inc | Preparation of sevoflurane with negligible water content |
| PL2244737T3 (pl) | 2008-01-22 | 2020-05-18 | The Board Of Regents Of The University Of Texas System | Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu |
| AU2015200210B2 (en) * | 2008-01-22 | 2016-08-11 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| US20090275785A1 (en) | 2008-05-01 | 2009-11-05 | Barry Jones | Distillation Method For The Purification Of Sevoflurane And The Maintenance Of Certain Equipment That May Be Used In The Distillation Process |
| AU2010245932B2 (en) * | 2009-05-05 | 2015-08-06 | Board Of Regents, The University Of Texas System | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
| US9102604B1 (en) | 2010-02-15 | 2015-08-11 | Baxter International Inc. | Methods for cleaning distilling columns |
| ES2873964T3 (es) * | 2013-03-15 | 2021-11-04 | Newvapogen Inc | Nuevas composiciones analgésicas |
| CN105106182B (zh) * | 2015-09-21 | 2017-12-29 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
| CN105193774B (zh) * | 2015-09-21 | 2018-01-16 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3216897A (en) * | 1961-11-02 | 1965-11-09 | Air Reduction | Injectable anesthetic |
| US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
| US6162443A (en) * | 1998-01-09 | 2000-12-19 | Abbott Laboratories | Container for an inhalation anesthetic |
| US6074668A (en) | 1998-01-09 | 2000-06-13 | Abbott Laboratories | Container for an inhalation anesthetic |
| US6271422B1 (en) * | 2000-06-01 | 2001-08-07 | Abbott Laboratories | Method for fluoromethylation of alcohols via halogenative decarboxylation |
| ATE429947T1 (de) * | 2001-08-29 | 2009-05-15 | Pharmakodex Ltd | Vorrichtung zur topischen verabreichung |
| GB0124071D0 (en) | 2001-10-08 | 2001-11-28 | Kbig Ltd | Improvement in the administration of high boiling point aneasthetics |
| CA2476589C (en) * | 2002-02-27 | 2014-02-25 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| MXPA06000803A (es) * | 2003-09-10 | 2006-08-23 | Cristalia Prod Quimicos Farm | Composicion farmaceutica estable del compuesto de fluoroeter para uso anestesico, metodo para estabilizar un compuesto de fluoroeter, uso del agente estabilizador para evitar la degradacion de un compuesto de fluoroeter. |
-
2004
- 2004-08-20 MX MXPA06000803A patent/MXPA06000803A/es active IP Right Grant
- 2004-08-20 PL PL04737744T patent/PL1663186T3/pl unknown
- 2004-08-20 ES ES04737744T patent/ES2289524T3/es active Active
- 2004-08-20 EP EP04737744A patent/EP1663186B1/de active Active
- 2004-08-20 US US10/566,466 patent/US7816409B2/en active Active
- 2004-08-20 AT AT04737744T patent/ATE365034T1/de not_active IP Right Cessation
- 2004-08-20 DE DE602004007149T patent/DE602004007149T2/de active Active
- 2004-08-20 JP JP2006525578A patent/JP4253343B2/ja active Active
- 2004-08-20 WO PCT/BR2004/000156 patent/WO2005023175A2/en active IP Right Grant
- 2004-08-20 PT PT04737744T patent/PT1663186E/pt unknown
-
2007
- 2007-12-19 HK HK07113847.1A patent/HK1108633A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7816409B2 (en) | 2010-10-19 |
| EP1663186A2 (de) | 2006-06-07 |
| ES2289524T3 (es) | 2008-02-01 |
| US20060228383A1 (en) | 2006-10-12 |
| DE602004007149D1 (de) | 2007-08-02 |
| DE602004007149T2 (de) | 2008-02-28 |
| JP2007505047A (ja) | 2007-03-08 |
| JP4253343B2 (ja) | 2009-04-08 |
| WO2005023175A2 (en) | 2005-03-17 |
| MXPA06000803A (es) | 2006-08-23 |
| PL1663186T3 (pl) | 2007-11-30 |
| WO2005023175A3 (en) | 2005-08-04 |
| WO2005023175B1 (en) | 2005-09-09 |
| EP1663186B1 (de) | 2007-06-20 |
| PT1663186E (pt) | 2007-09-27 |
| HK1108633A1 (en) | 2008-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |