DE60333379D1 - Tricyclische tetrahydrochinoline mit antibakterieller wirkung - Google Patents

Tricyclische tetrahydrochinoline mit antibakterieller wirkung

Info

Publication number
DE60333379D1
DE60333379D1 DE60333379T DE60333379T DE60333379D1 DE 60333379 D1 DE60333379 D1 DE 60333379D1 DE 60333379 T DE60333379 T DE 60333379T DE 60333379 T DE60333379 T DE 60333379T DE 60333379 D1 DE60333379 D1 DE 60333379D1
Authority
DE
Germany
Prior art keywords
tetrahydrochinoline
tricyclic
antibacterial effect
antibacterial
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333379T
Other languages
English (en)
Inventor
M R Barbachyn
P J Dobrowolski
A R Hurd
D J Mcnamara
John Raymond Palmer
A G Romero
James Craig Ruble
D A Sherry
L M Thomasco
P L Toogood
Gordon L Bundy
Gary E Martin
Donna L Romero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60333379D1 publication Critical patent/DE60333379D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60333379T 2002-10-07 2003-10-03 Tricyclische tetrahydrochinoline mit antibakterieller wirkung Expired - Lifetime DE60333379D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41668502P 2002-10-07 2002-10-07
US42718902P 2002-11-18 2002-11-18
US45762203P 2003-03-26 2003-03-26
PCT/IB2003/004389 WO2004031195A1 (en) 2002-10-07 2003-10-03 Tricyclic tetrahydroquinoline antibacterial agents

Publications (1)

Publication Number Publication Date
DE60333379D1 true DE60333379D1 (de) 2010-08-26

Family

ID=32074379

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333379T Expired - Lifetime DE60333379D1 (de) 2002-10-07 2003-10-03 Tricyclische tetrahydrochinoline mit antibakterieller wirkung

Country Status (16)

Country Link
US (4) US7208490B2 (de)
EP (1) EP1551849B1 (de)
JP (1) JP4009652B2 (de)
AR (1) AR041546A1 (de)
AT (1) ATE473985T1 (de)
AU (1) AU2003264768A1 (de)
BR (1) BR0315139A (de)
CA (1) CA2500824C (de)
CY (1) CY1110821T1 (de)
DE (1) DE60333379D1 (de)
DK (1) DK1551849T3 (de)
MX (1) MXPA05002701A (de)
PT (1) PT1551849E (de)
SI (1) SI1551849T1 (de)
TW (1) TWI295671B (de)
WO (1) WO2004031195A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
JP2008543739A (ja) * 2005-05-09 2008-12-04 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 抗菌剤
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
JP2010531868A (ja) * 2007-07-02 2010-09-30 アストラゼネカ アクチボラグ ３−スピロピリミジントリオン−キノリン誘導体と抗菌剤としてのその使用
EP2178876A1 (de) 2007-07-16 2010-04-28 AstraZeneca AB Spirokondensierte barbitursäurederivate zur verwendung als antibakterielle mittel
JP5749169B2 (ja) * 2008-10-14 2015-07-15 アストラゼネカ アクチボラグ 細菌感染の処置用の縮合スピロ環式ヘテロ芳香族化合物
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
CN102245604A (zh) * 2008-12-23 2011-11-16 雅培制药有限公司 抗病毒化合物
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
AU2011278926B2 (en) 2010-07-16 2014-09-25 Abbvie Ireland Unlimited Company Phosphine ligands for catalytic reactions
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
UA115025C2 (uk) 2010-07-16 2017-09-11 Еббві Айрленд Анлімітед Компані Спосіб одержання противірусних сполук
RU2644250C2 (ru) * 2012-09-14 2018-02-08 Элизабет ЛЕВИНА Лекарственное средство с активностью против грамположительных бактерий, микобактерий и грибов
US8952149B2 (en) 2012-09-26 2015-02-10 Zoetis Llc Tricyclic tetrahydroquinoline antibacterial agents
US8889671B2 (en) * 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
EP3148546A1 (de) * 2014-05-29 2017-04-05 Entasis Therapeutics Limited Kondensierte spirocyclische heteroaromatische verbindungen zur behandlung von bakteriellen infektionen
US10995097B2 (en) 2016-03-11 2021-05-04 The Board Of Trustees Of The University Of Illinois Small molecules active against gram-negative bacteria
US11274106B2 (en) 2017-06-23 2022-03-15 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and anticancer activity
CN108101860B (zh) * 2018-02-08 2021-11-23 苏州敬业医药化工有限公司 顺式-2，6-二甲基吗啉的制备方法
CN115466212B (zh) * 2022-10-26 2023-09-22 河南农业大学 一种2-三氟甲基喹啉类化合物及其合成方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011860A (en) * 1986-04-11 1991-04-30 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases
DE19502178A1 (de) * 1994-01-27 1995-08-03 Hoechst Ag Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen
AU2002210813A1 (en) 2000-10-26 2002-05-06 Pfizer Products Inc. Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
WO2003091252A1 (en) 2002-04-25 2003-11-06 Bristol-Myers Squibb Company Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
AU2003265090A1 (en) 2002-10-10 2004-05-04 Pharmacia & Upjohn Comapny LLC Antimicrobial 1-aryl dihydropyridone compounds

Also Published As

Publication number Publication date
US20040162279A1 (en) 2004-08-19
US8420646B2 (en) 2013-04-16
US20100022524A1 (en) 2010-01-28
US7605157B2 (en) 2009-10-20
CY1110821T1 (el) 2015-06-10
TWI295671B (en) 2008-04-11
WO2004031195A1 (en) 2004-04-15
ATE473985T1 (de) 2010-07-15
CA2500824C (en) 2011-03-22
PT1551849E (pt) 2010-09-27
BR0315139A (pt) 2005-08-09
EP1551849B1 (de) 2010-07-14
SI1551849T1 (sl) 2010-11-30
JP4009652B2 (ja) 2007-11-21
DK1551849T3 (da) 2010-10-25
CA2500824A1 (en) 2004-04-15
US7208490B2 (en) 2007-04-24
US20070161630A1 (en) 2007-07-12
MXPA05002701A (es) 2005-08-19
AR041546A1 (es) 2005-05-18
TW200413394A (en) 2004-08-01
AU2003264768A1 (en) 2004-04-23
EP1551849A1 (de) 2005-07-13
JP2006511595A (ja) 2006-04-06
US20110092494A1 (en) 2011-04-21

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