DE60331138D1 - Verfahren zur herstellung von 6-alkyliden-penemderivaten - Google Patents

Verfahren zur herstellung von 6-alkyliden-penemderivaten

Info

Publication number
DE60331138D1
DE60331138D1 DE60331138T DE60331138T DE60331138D1 DE 60331138 D1 DE60331138 D1 DE 60331138D1 DE 60331138 T DE60331138 T DE 60331138T DE 60331138 T DE60331138 T DE 60331138T DE 60331138 D1 DE60331138 D1 DE 60331138D1
Authority
DE
Germany
Prior art keywords
preparation
penem derivatives
alkylidene
alkylidene penem
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60331138T
Other languages
English (en)
Inventor
Takao Abe
Hiroshi Matsunaga
Ado Mihira
Chisato Sato
Hideki Ushirogochi
Koichi Sato
Tsuyoshi Takasaki
Aranapakam Mudumbai Venkatesan
Tarek Suhayl Mansour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60331138D1 publication Critical patent/DE60331138D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60331138T 2002-05-01 2003-04-30 Verfahren zur herstellung von 6-alkyliden-penemderivaten Expired - Fee Related DE60331138D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37704802P 2002-05-01 2002-05-01
PCT/US2003/013429 WO2003093277A1 (en) 2002-05-01 2003-04-30 Process for preparing 6-alkylidene penem derivatives

Publications (1)

Publication Number Publication Date
DE60331138D1 true DE60331138D1 (de) 2010-03-18

Family

ID=29401435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331138T Expired - Fee Related DE60331138D1 (de) 2002-05-01 2003-04-30 Verfahren zur herstellung von 6-alkyliden-penemderivaten

Country Status (23)

Country Link
US (1) US20040053913A1 (de)
EP (1) EP1499620B1 (de)
JP (1) JP2005523937A (de)
KR (1) KR20050007369A (de)
CN (1) CN100516069C (de)
AR (1) AR039476A1 (de)
AT (1) ATE456569T1 (de)
AU (2) AU2003228773A1 (de)
BR (1) BR0309753A (de)
CA (1) CA2483533A1 (de)
CR (1) CR7512A (de)
DE (1) DE60331138D1 (de)
EC (1) ECSP045396A (de)
IL (1) IL164900A0 (de)
MX (1) MXPA04010661A (de)
NO (1) NO20044548L (de)
NZ (1) NZ536183A (de)
RU (1) RU2317297C2 (de)
SG (1) SG165159A1 (de)
TW (1) TW200403248A (de)
UA (1) UA78047C2 (de)
WO (1) WO2003093277A1 (de)
ZA (1) ZA200409687B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US7316917B2 (en) 2003-05-16 2008-01-08 Wyeth Holdings Corporation Production of bicyclic-heteroaryl-2-carboxylic acids by selective enzymatic hydrolysis of a mixture of positional esters
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
CA2616468A1 (en) * 2005-07-27 2007-03-08 Wyeth Tricyclic 6-alkylidene-penem .beta.-lactamase inhibitors and .beta.-lactam antibiotic combination: a broad spectrum antibiotic
BRPI0613927A2 (pt) * 2005-07-27 2011-02-15 Wyeth Corp uso de cefepima ou um sal farmaceuticamente aceitável desta e um composto da fórmula i ou um sal farmaceuticamente aceitável ou éster deste hidrolisável in vivo; composição; embalagem; e produto
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
US20100063023A1 (en) * 2008-09-10 2010-03-11 Wyeth Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors
CN102020658B (zh) * 2009-09-11 2012-05-23 中国中化股份有限公司 2-氯-6，8-二氢-5H-咪唑[2，1-c]-[1，4]噁嗪及其制备方法
CN102020615B (zh) * 2009-09-11 2012-08-29 中国中化股份有限公司 一种吗啉酮衍生物及其制备方法
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
CA2885692C (en) 2012-09-25 2018-05-22 Bayer Cropscience Ag Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
ATE159021T1 (de) * 1986-01-17 1997-10-15 Beecham Group Plc Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
US4977256A (en) * 1987-12-07 1990-12-11 Lederle (Japan), Ltd. Method of eliminating protective groups
GB8729613D0 (en) * 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
CN1094353C (zh) * 1994-04-25 2002-11-20 史密斯克莱·比奇曼公司 含有β－内酰胺酶抑制性青霉烯与β－内酰胺抗生素复合的药物制剂及其在治疗细菌感染中的应用
ATE233089T1 (de) * 1998-10-15 2003-03-15 Sarawak Medichem Pharmaceuticals Inc Verfahren und zusammensetzung zur behandlung und vorbeugung von mycobacterium infektionen
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos

Also Published As

Publication number Publication date
JP2005523937A (ja) 2005-08-11
EP1499620A1 (de) 2005-01-26
CR7512A (es) 2005-01-05
RU2317297C2 (ru) 2008-02-20
BR0309753A (pt) 2005-03-08
WO2003093277A1 (en) 2003-11-13
ATE456569T1 (de) 2010-02-15
EP1499620B1 (de) 2010-01-27
CA2483533A1 (en) 2003-11-13
SG165159A1 (en) 2010-10-28
MXPA04010661A (es) 2005-01-25
ECSP045396A (es) 2005-01-03
US20040053913A1 (en) 2004-03-18
NO20044548L (no) 2004-11-26
ZA200409687B (en) 2009-02-25
TW200403248A (en) 2004-03-01
IL164900A0 (en) 2005-12-18
AU2010200930A1 (en) 2010-04-01
AU2003228773A1 (en) 2003-11-17
CN100516069C (zh) 2009-07-22
NZ536183A (en) 2006-07-28
CN1649881A (zh) 2005-08-03
AR039476A1 (es) 2005-02-23
KR20050007369A (ko) 2005-01-17
UA78047C2 (en) 2007-02-15
RU2004135088A (ru) 2006-01-20

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee