DE60330159D1 - Bittergeschmack-rezeptoren - Google Patents

Bittergeschmack-rezeptoren

Info

Publication number
DE60330159D1
DE60330159D1 DE60330159T DE60330159T DE60330159D1 DE 60330159 D1 DE60330159 D1 DE 60330159D1 DE 60330159 T DE60330159 T DE 60330159T DE 60330159 T DE60330159 T DE 60330159T DE 60330159 D1 DE60330159 D1 DE 60330159D1
Authority
DE
Germany
Prior art keywords
bitter taste
taste receptors
receptors
bitter
taste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330159T
Other languages
English (en)
Inventor
Bernd Bufe
Thomas Hofmann
Dietmar Krautwurst
Christina Kuhn
Wolfgang Meyerhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Original Assignee
Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke filed Critical Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Application granted granted Critical
Publication of DE60330159D1 publication Critical patent/DE60330159D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60330159T 2002-09-25 2003-09-25 Bittergeschmack-rezeptoren Expired - Lifetime DE60330159D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41329802P 2002-09-25 2002-09-25
PCT/EP2003/010691 WO2004029087A2 (en) 2002-09-25 2003-09-25 Bitter taste receptors

Publications (1)

Publication Number Publication Date
DE60330159D1 true DE60330159D1 (de) 2009-12-31

Family

ID=32043229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330159T Expired - Lifetime DE60330159D1 (de) 2002-09-25 2003-09-25 Bittergeschmack-rezeptoren

Country Status (5)

Country Link
US (3) US7413867B2 (de)
EP (12) EP2270156A3 (de)
AU (1) AU2003267411A1 (de)
DE (1) DE60330159D1 (de)
WO (1) WO2004029087A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2403003A1 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. T2r taste receptors and genes encoding same
US8030008B2 (en) * 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7883856B2 (en) * 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
AU2002326429B2 (en) 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
US7579453B2 (en) 2003-06-19 2009-08-25 The United States Of America As Represented By The Secretary Of The Dapartment Of Health And Human Services Variants of human taste receptor genes
KR20070053659A (ko) 2004-04-20 2007-05-25 도이체스 인스티튜트 퓌어 에른에룬그스포슝 쓴맛 수용체의 작용제 및 그의 용도
WO2006053771A2 (en) 2004-11-18 2006-05-26 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
CN101522702A (zh) * 2006-09-05 2009-09-02 塞诺米克斯公司 人T2R受体hT2R50的新单体型及其在鉴定人苦味调节剂的测定法中的用途
EP1975611A1 (de) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonisten von Bittergeschmackrezeptoren und ihre Verwendung
EP1975612A1 (de) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonisten von Bittergeschmackrezeptoren und ihre Verwendung
JP5465656B2 (ja) 2007-03-30 2014-04-09 ジボダン エス エー 調節物質を同定するための方法
ATE555670T1 (de) 2007-03-30 2012-05-15 Givaudan Sa Off-note-blockierende sensorische organische verbindungen
EP1983342A1 (de) * 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antagonisten von Bittergeschmacksrezeptoren und Verwendungen davon
US20110003711A1 (en) * 2008-02-01 2011-01-06 Chromocell Corporation Cell lines expressing gaba receptor and methods using them
EP2391711B1 (de) * 2009-02-02 2015-04-08 Chromocell Corporation Neue zelllinien und verfahren
US8709745B2 (en) 2009-07-28 2014-04-29 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating ligands of the human bitter taste receptor TAS2R49
KR20130055595A (ko) 2010-04-15 2013-05-28 크로모셀 코포레이션 쓴맛을 감소시키거나 제거하기 위한 화합물, 조성물 및 방법
EP2742350B1 (de) 2011-08-08 2019-10-30 The Coca-Cola Company Zelllinien mit endogenen geschmacksrezptoren und deren verwendungen
JP6122858B2 (ja) 2011-10-20 2017-04-26 クロモセル コーポレーション 苦味を調整する化合物を同定するための検定
CN103998028B (zh) 2011-10-20 2017-12-08 卓莫赛尔公司 用于减小或消除苦味的化合物、组合物和方法
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
EP2767829A1 (de) 2013-02-18 2014-08-20 Universität Wien Verfahren zur Identifizierung von Bitterstoffen und bittermodulierenden Stoffen
EP2946208A1 (de) 2013-01-17 2015-11-25 Universität Wien Verfahren zur identifizierung von bittergeschmacksverbindungen und bittergeschmack-modulierende verbindungen
ES2797547T3 (es) 2013-03-15 2020-12-02 Applied Food Biotech Inc Receptores del sabor amargo felino y métodos.
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
SG11201508572UA (en) 2013-04-24 2015-11-27 Chromocell Corp Assays for identifying compounds that modulate bitter taste
US10301275B2 (en) 2017-03-17 2019-05-28 Altria Client Services Llc Sweet taste modulators
WO2023205647A1 (en) * 2022-04-19 2023-10-26 Firmenich Incorporated Reduction of bitter taste of active pharmaceutical ingredients and related assays and screening methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001034767A2 (en) * 1999-11-05 2001-05-17 Human Genome Sciences, Inc. 22 human secreted proteins
EP1214343A2 (de) * 1999-09-10 2002-06-19 The Regents Of The University Of California T2r geschmacksrezeptorfamilie
CA2403003A1 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. T2r taste receptors and genes encoding same
WO2002057309A1 (fr) * 2001-01-18 2002-07-25 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a la proteine g et adn de cette proteine
AU2002326429B2 (en) * 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
CA2463553A1 (en) * 2001-10-12 2003-04-17 The Regents Of The University Of California Gastrointestinal chemosensory receptors
US7579453B2 (en) * 2003-06-19 2009-08-25 The United States Of America As Represented By The Secretary Of The Dapartment Of Health And Human Services Variants of human taste receptor genes

Also Published As

Publication number Publication date
EP2267128A2 (de) 2010-12-29
EP2272957A2 (de) 2011-01-12
EP2267129A3 (de) 2011-08-03
EP2270155A3 (de) 2011-08-10
US20110177085A1 (en) 2011-07-21
US7413867B2 (en) 2008-08-19
EP2270156A2 (de) 2011-01-05
EP2270154A2 (de) 2011-01-05
WO2004029087A3 (en) 2004-07-01
WO2004029087A2 (en) 2004-04-08
EP2163623A2 (de) 2010-03-17
US20060248602A1 (en) 2006-11-02
EP1543122B1 (de) 2009-11-18
EP2267129B1 (de) 2015-03-25
US20080287364A1 (en) 2008-11-20
EP2270156A3 (de) 2011-08-10
EP2267128A3 (de) 2011-08-10
US8709737B2 (en) 2014-04-29
EP2270155A2 (de) 2011-01-05
EP2270153A3 (de) 2011-08-10
EP2267129A2 (de) 2010-12-29
AU2003267411A8 (en) 2004-04-19
EP2270157A3 (de) 2011-08-03
EP2163623A3 (de) 2010-05-26
EP2267130A2 (de) 2010-12-29
EP1543122A2 (de) 2005-06-22
EP2270157A2 (de) 2011-01-05
EP2270158A3 (de) 2011-08-03
EP2270158A2 (de) 2011-01-05
AU2003267411A1 (en) 2004-04-19
US7955808B2 (en) 2011-06-07
EP2267130A3 (de) 2011-08-03
EP2270154A3 (de) 2011-08-10
EP2270153A2 (de) 2011-01-05
EP2272957A3 (de) 2011-08-03

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