DE60329377D1 - Methode zur vorhersage der sepsis in einem patienten mit systemischem inflammatorischem response-syndrom (sirs) - Google Patents

Methode zur vorhersage der sepsis in einem patienten mit systemischem inflammatorischem response-syndrom (sirs)

Info

Publication number
DE60329377D1
DE60329377D1 DE60329377T DE60329377T DE60329377D1 DE 60329377 D1 DE60329377 D1 DE 60329377D1 DE 60329377 T DE60329377 T DE 60329377T DE 60329377 T DE60329377 T DE 60329377T DE 60329377 D1 DE60329377 D1 DE 60329377D1
Authority
DE
Germany
Prior art keywords
sepsis
inflammatory response
sirs
forecasting
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329377T
Other languages
English (en)
Inventor
Stephen J Anderson
Douglas J Haney
Cory A Waters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Application granted granted Critical
Publication of DE60329377D1 publication Critical patent/DE60329377D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G01N2333/70553Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/26Infectious diseases, e.g. generalised sepsis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60329377T 2002-04-02 2003-03-27 Methode zur vorhersage der sepsis in einem patienten mit systemischem inflammatorischem response-syndrom (sirs) Expired - Lifetime DE60329377D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37011502P 2002-04-02 2002-04-02
PCT/US2003/009351 WO2003084388A2 (en) 2002-04-02 2003-03-27 Early detection of sepsis

Publications (1)

Publication Number Publication Date
DE60329377D1 true DE60329377D1 (de) 2009-11-05

Family

ID=28792031

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329377T Expired - Lifetime DE60329377D1 (de) 2002-04-02 2003-03-27 Methode zur vorhersage der sepsis in einem patienten mit systemischem inflammatorischem response-syndrom (sirs)

Country Status (6)

Country Link
US (1) US7465555B2 (de)
EP (1) EP1490789B1 (de)
JP (1) JP4520157B2 (de)
AT (1) ATE443867T1 (de)
DE (1) DE60329377D1 (de)
WO (1) WO2003084388A2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9468378B2 (en) 1997-01-27 2016-10-18 Lawrence A. Lynn Airway instability detection system and method
US8932227B2 (en) 2000-07-28 2015-01-13 Lawrence A. Lynn System and method for CO2 and oximetry integration
US9042952B2 (en) 1997-01-27 2015-05-26 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US20070191697A1 (en) 2006-02-10 2007-08-16 Lynn Lawrence A System and method for SPO2 instability detection and quantification
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US7184963B1 (en) * 1999-01-19 2007-02-27 Bristol-Myers Squibb Company Method for determining care and prevention pathways for clinical management of wounds
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US9053222B2 (en) 2002-05-17 2015-06-09 Lawrence A. Lynn Patient safety processor
US20060195041A1 (en) 2002-05-17 2006-08-31 Lynn Lawrence A Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions
US7465555B2 (en) * 2002-04-02 2008-12-16 Becton, Dickinson And Company Early detection of sepsis
US20050288571A1 (en) * 2002-08-20 2005-12-29 Welch Allyn, Inc. Mobile medical workstation
CA2505785A1 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
BR0316231A (pt) * 2002-11-12 2005-10-04 Becton Dickinson Co Métodos para determinar o estado de sepsia para prognosticar o começo de sepsia e para diagnosticar a sìndrome de resposta inflamatória sistêmica em um indivìduo e para isolar um biomarcador, perfil biomarcador r kit
WO2004044555A2 (en) 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
EP1611255A2 (de) * 2003-04-02 2006-01-04 SIRS-Lab GmbH Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsis ähnlichen zuständen und systemischen infektionen
ES2596827T3 (es) 2003-11-17 2017-01-12 Biomarin Pharmaceutical Inc. Tratamiento de la fenilcetonuria con BH4
EP1692506A4 (de) * 2003-11-17 2008-01-09 Janssen Pharmaceutica Nv Modellierung einer systemischen entzündlichen reaktion auf eine infektion
DE102004009952B4 (de) * 2004-03-01 2011-06-01 Sirs-Lab Gmbh Verfahren zur Erkennung von Sepsis
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
EP1734941A2 (de) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neurale staubinde
DE102004015605B4 (de) * 2004-03-30 2012-04-26 Sirs-Lab Gmbh Verfahren zur Vorhersage des individuellen Krankheitsverlaufs bei Sepsis
DE102004049897B4 (de) * 2004-10-13 2007-11-22 Sirs-Lab Gmbh Verfahren zur Unterscheidung zwischen nichtinfektiösen und infektiösen Ursachen eines Multiorganversagens
JP5047803B2 (ja) 2004-11-19 2012-10-10 トリリウム ダイアグノスティクス,エルエルシー 白血球FcγRI受容体(CD64)の定量化のための、ソフトウェアを統合したフローサイトメトリーアッセイ
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
EP1833559B1 (de) 2004-12-27 2010-11-24 The Feinstein Institute for Medical Research Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
DE102005013013A1 (de) * 2005-03-21 2006-09-28 Sirs-Lab Gmbh Verwendung von Genaktivitäts-Klassifikatoren für die in vitro Klassifizierung von Genexpressionsprofilen von Patienten mit infektiösem/nichtinfektiösem Multiorganversagen
AU2006236588A1 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
AU2006269820B2 (en) * 2005-07-07 2012-01-19 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
EP1904941A4 (de) * 2005-07-18 2009-10-21 Integralis Ltd Vorrichtung, verfahren und computerlesbarer code zur vorhersage des aufkommens einer potentiell lebensgefährlichen krankheit
KR101281298B1 (ko) 2005-09-28 2013-07-08 백톤 디킨슨 앤드 컴퍼니 전신성 염증 상태를 예측 또는 진단하기 위한 리소포스파티딜콜린의 검출
DE102005050933A1 (de) * 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US7668579B2 (en) 2006-02-10 2010-02-23 Lynn Lawrence A System and method for the detection of physiologic response to stimulation
US20070264663A1 (en) * 2006-05-02 2007-11-15 O'brien Peter J Methods and reagents for detecting susceptibility to graft versus host disease or transplant related mortality
GB0610078D0 (en) * 2006-05-20 2006-06-28 Secr Defence Sepsis detection microarray
US20090104605A1 (en) * 2006-12-14 2009-04-23 Gary Siuzdak Diagnosis of sepsis
US8221995B2 (en) 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7734353B2 (en) 2007-04-19 2010-06-08 Medtronic Inc. Controlling temperature during recharge for treatment of infection or other conditions
US7611483B2 (en) * 2007-04-19 2009-11-03 Medtronic, Inc. Indicator metrics for infection monitoring
US20080262331A1 (en) * 2007-04-19 2008-10-23 Medtronic, Inc. Infection monitoring
US7682355B2 (en) * 2007-04-19 2010-03-23 Medtronic, Inc. Refined infection monitoring
US20080262374A1 (en) * 2007-04-19 2008-10-23 Medtronic, Inc. Event triggered infection monitoring
WO2008143890A2 (en) * 2007-05-14 2008-11-27 Children's Hospital Medical Center Biomarkers for septic shock patients
RU2475849C2 (ru) * 2007-07-13 2013-02-20 Конинклейке Филипс Электроникс Н.В. Система содействия принятию решений для острых функциональных заболеваний
US8391970B2 (en) 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
WO2009033050A1 (en) * 2007-09-07 2009-03-12 University Of Pittsburgh-Of The Commonwealth Sys Tem Of Higher Education Diagnostic and therapeutic uses of augmenter of liver regeneration in inflammatory conditions
GB0722729D0 (en) * 2007-11-20 2007-12-27 Bristol Myers Squibb Co Diagnostic markers of wound infection
DE102008000715B9 (de) 2008-03-17 2013-01-17 Sirs-Lab Gmbh Verfahren zur in vitro Erfasssung und Unterscheidung von pathophysiologischen Zuständen
MX337333B (es) * 2008-03-26 2016-02-26 Theranos Inc Metodos y sistemas para evaluar resultados clinicos.
AU2013231105B2 (en) * 2008-03-26 2016-07-07 Theranos Ip Company, Llc Methods and systems for assessing clinical outcomes
WO2009146030A1 (en) 2008-03-31 2009-12-03 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of t-cell activity
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
WO2009137682A1 (en) 2008-05-07 2009-11-12 Lynn Lawrence A Medical failure pattern search engine
US11728041B2 (en) 2008-05-07 2023-08-15 Lawrence A. Lynn Real-time time series matrix pathophysiologic pattern processor and quality assessment method
US8380531B2 (en) * 2008-07-25 2013-02-19 Invivodata, Inc. Clinical trial endpoint development process
CA2740191A1 (en) * 2008-10-09 2010-04-15 Thomas Ryan A method of estimating risk of severe sepsis in an individual with infection
CN102215909B (zh) 2008-11-18 2014-09-10 赛博恩特医疗器械公司 优化用于消炎刺激的电极放置的装置和方法
US8788034B2 (en) 2011-05-09 2014-07-22 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
EP2438447B1 (de) * 2009-06-05 2015-02-18 B.R.A.H.M.S GmbH Nachweis von bakteriellen Infektionen bei an Dyspnoe leidenden Patienten.
CN102573986B (zh) 2009-06-09 2016-01-20 赛博恩特医疗器械公司 用于无导线刺激器的具有袋部的神经封套
DE102009044085A1 (de) 2009-09-23 2011-11-17 Sirs-Lab Gmbh Verfahren zur in vitro Erfassung und Unterscheidung von pathophysiologischen Zuständen
EP2309001A1 (de) 2009-09-23 2011-04-13 SIRS-Lab GmbH Verfahren zur in vitro Erfassung und Unterscheidung von pathophysiologischen Zuständen
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
EP3636314B1 (de) 2009-12-23 2021-09-08 Setpoint Medical Corporation Nervenstimulatoren und systeme zur behandlung von chronischer entzündung
EP2558870B1 (de) * 2010-04-15 2017-06-07 Leukodx Ltd Vorrichtung und verfahren zur schnellen bestimmung eines medizinischen leidens
GB2482187A (en) * 2010-07-23 2012-01-25 Univ Exeter Predicting response to surgery
FR2970975B1 (fr) * 2011-01-27 2016-11-04 Biomerieux Sa Procede et kit pour determiner in vitro le statut immunitaire d'un individu
DE102011005235B4 (de) 2011-03-08 2017-05-24 Sirs-Lab Gmbh Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
US9267175B2 (en) 2012-02-07 2016-02-23 Children's Hospital Medical Center Multi-biomarker-based outcome risk stratification model for adult septic shock
EP2812693B1 (de) 2012-02-07 2017-07-19 Children's Hospital Medical Center Auf mehreren biomarkern basierendes ergebnisrisikostratifizierungsmodell für septischen schock in der pädiatrie
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
WO2013183001A1 (en) 2012-06-05 2013-12-12 Cheetah Medical, Inc. Method and system for assessing likelihood of sepsis
WO2014024176A1 (en) * 2012-08-09 2014-02-13 Koninklijke Philips N.V. Device for home monitoring of haematological parameters of patients
US10354429B2 (en) 2012-11-14 2019-07-16 Lawrence A. Lynn Patient storm tracker and visualization processor
US9953453B2 (en) 2012-11-14 2018-04-24 Lawrence A. Lynn System for converting biologic particle density data into dynamic images
CN105051538B (zh) 2012-12-17 2018-06-15 伦珂德克斯有限公司 用于检测生物状况的系统和方法
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US9759722B2 (en) * 2012-12-17 2017-09-12 Leukodx Ltd. Systems and methods for determining a chemical state
GB201301611D0 (en) 2013-01-30 2013-03-13 Shaw Andrew M Systems and methods for medical data processing and analysis
WO2014134526A1 (en) 2013-02-28 2014-09-04 Lynn Lawrence A System for analysis and imaging using perturbation feature quanta
SG11201510282PA (en) * 2013-06-28 2016-01-28 Acumen Res Lab Pte Ltd Sepsis biomarkers and uses thereof
US20160195544A1 (en) * 2013-08-07 2016-07-07 University Of Rochester Method of diagnosing sepsis or sepsis risk
WO2015077781A1 (en) 2013-11-25 2015-05-28 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
JP6355154B2 (ja) * 2014-04-03 2018-07-11 公益財団法人ヒューマンサイエンス振興財団 診断補助方法
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10261068B2 (en) 2015-06-04 2019-04-16 Children's Hospital Medical Center Persevere-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
CN114904142A (zh) 2016-01-20 2022-08-16 赛博恩特医疗器械公司 迷走神经刺激的控制
WO2017127758A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
RU2653631C2 (ru) * 2016-10-05 2018-05-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России) Способ прогноза летальности при гнойно-септических инфекциях в эксперименте
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
CN109030815B (zh) * 2018-06-26 2021-08-10 安徽医科大学 一种用于检测液相蛋白质交互作用的蛋白质芯片及其制备方法和应用
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US20220299511A1 (en) * 2019-06-17 2022-09-22 The Broad Institute, Inc. Immune cell signature for bacterial sepsis
KR20230012585A (ko) 2020-05-21 2023-01-26 더 파인스타인 인스티튜츠 포 메디칼 리서치 미주 신경 자극을 위한 시스템들 및 방법들

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1504597A1 (ru) 1986-06-25 1989-08-30 Актюбинский государственный медицинский институт Способ дифференциальной диагностики сепсиса и локализованной гнойной инфекции у новорожденных
EP0406673B1 (de) * 1989-07-01 1995-08-30 Barmag Ag Falschzwirnkräuselmaschine für einen synthetischen Faden
EP0571442A4 (de) 1991-01-14 1995-05-03 Univ New York Cytokin-induzierbares protein tsg-14, seine kodierende dna und ihre verwendung.
DE4227454C1 (de) 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
RU2072103C1 (ru) 1993-06-10 1997-01-20 Ростовский научно-исследовательский институт акушерства и педиатрии Способ диагностики бактериальных инфекций у новорожденных
US5484705A (en) 1994-01-24 1996-01-16 Xoma Corporation Method for quantifying lipopolysaccharide binding protein
US6190872B1 (en) 1994-05-06 2001-02-20 Gus J. Slotman Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method
US5804370A (en) * 1994-06-08 1998-09-08 Critichem Medical Products Limited Early diagnosis of sepsis utilizing antigen-antibody interactions amplified by whole blood chemiluminescence
US5566249A (en) * 1994-09-20 1996-10-15 Neopath, Inc. Apparatus for detecting bubbles in coverslip adhesive
US5780237A (en) 1994-10-12 1998-07-14 Cell Therapeutics, Inc. Sepsis, adult respiratory distress syndrome, and systemic inflammatory response syndrome diagnostic
US5830679A (en) 1996-03-01 1998-11-03 New England Medical Center Hospitals, Inc. Diagnostic blood test to identify infants at risk for sepsis
US6077665A (en) * 1996-05-07 2000-06-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid assay for infection in neonates
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7144710B2 (en) * 2000-03-28 2006-12-05 Trustees Of Dartmouth College Method for detecting inflammation and inflammatory conditions
US7465555B2 (en) * 2002-04-02 2008-12-16 Becton, Dickinson And Company Early detection of sepsis

Also Published As

Publication number Publication date
US7465555B2 (en) 2008-12-16
EP1490789A2 (de) 2004-12-29
JP4520157B2 (ja) 2010-08-04
ATE443867T1 (de) 2009-10-15
EP1490789A4 (de) 2006-08-30
US20030194752A1 (en) 2003-10-16
WO2003084388A2 (en) 2003-10-16
WO2003084388A3 (en) 2004-08-12
EP1490789B1 (de) 2009-09-23
JP2005521882A (ja) 2005-07-21

Similar Documents

Publication Publication Date Title
DE60329377D1 (de) Methode zur vorhersage der sepsis in einem patienten mit systemischem inflammatorischem response-syndrom (sirs)
TW200616578A (en) Fluid handling devices
DE502007006125D1 (de) Elektrochemischer sensor zur ermittlung einer analyt-konzentration
ATE440151T1 (de) Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum
ATE476659T1 (de) Sensor für mehrere analyte
WO2007126444A3 (en) Analyte monitoring
DE602005027168D1 (de) Batterie, Verfahren zur deren Herstellung und Verfahren zum Prüfen von Elektrolytverlust
FI20030598A (fi) Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä
WO2008089994A8 (en) Use of igfbp-7 in the assessment of heart failure
ATE480642T1 (de) Verfahren zur bestimmung von genotoxizität
EP1722224A4 (de) Verfahren zur bewertung der transparenz und feuchtigkeitsretention der hornschicht unter verwendung eines oxidierten proteins in der hornschicht als indikation
Pelkonen Lapsiperheiden voimavarat ja niiden vahvistaminen hoitotyon keinoin.
BR112016004320A2 (pt) biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste
NZ551782A (en) Agents and methods for diagnosing stress
RU2013138721A (ru) Способы и наборы для прогнозирования риска дыхательной недостаточности, почечной недостаточности или тромбопении у пациента, страдающего сепсисом, путем измерения уровней эндокана в крови
CA2510377A1 (en) Use of nicotinamide n-methyltransferase as a marker for colorectal cancer
JP2017505897A5 (de)
ATE550668T1 (de) Verfahren zur identifizierung von patienten mit erhöhtem risiko für ein unerwünschtes herz- kreislauf-ereignis
ATE490721T1 (de) Verfahren zur umrechnung von venösen blutwerten in arterielle blutwerte, system zur verwendung der methode
ATE426675T1 (de) Differenzialdiagnostik mit hepcidin
ATE506069T1 (de) Verfahren und zusammensetzung zur modulation des systemischen entzündlichen reaktionssyndroms (sirs)
DE602005011806D1 (de) Rna-biotest
ATE472611T1 (de) Verfahren zur diagnose von sepsis durch analyse von cytokine mrna expression
ATE507765T1 (de) Verfahren zur bestimmung der lebensfähigkeit von zellen
EP2508886A3 (de) Mittel und Verfahren zur Klassifizierung von Proben von Multiple-Sklerose-Patienten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition