ATE480642T1 - Verfahren zur bestimmung von genotoxizität - Google Patents
Verfahren zur bestimmung von genotoxizitätInfo
- Publication number
- ATE480642T1 ATE480642T1 AT05804099T AT05804099T ATE480642T1 AT E480642 T1 ATE480642 T1 AT E480642T1 AT 05804099 T AT05804099 T AT 05804099T AT 05804099 T AT05804099 T AT 05804099T AT E480642 T1 ATE480642 T1 AT E480642T1
- Authority
- AT
- Austria
- Prior art keywords
- genotoxicity
- determining
- determining genotoxicity
- reagents
- methods
- Prior art date
Links
- 231100000025 genetic toxicology Toxicity 0.000 title abstract 2
- 230000001738 genotoxic effect Effects 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63067204P | 2004-11-24 | 2004-11-24 | |
| PCT/EP2005/012209 WO2006056340A2 (en) | 2004-11-24 | 2005-11-15 | Method for determining genotoxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480642T1 true ATE480642T1 (de) | 2010-09-15 |
Family
ID=35709224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05804099T ATE480642T1 (de) | 2004-11-24 | 2005-11-15 | Verfahren zur bestimmung von genotoxizität |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7745152B2 (de) |
| EP (1) | EP1817427B1 (de) |
| JP (1) | JP4573876B2 (de) |
| CN (1) | CN101065501A (de) |
| AT (1) | ATE480642T1 (de) |
| CA (1) | CA2587548C (de) |
| DE (1) | DE602005023517D1 (de) |
| ES (1) | ES2350231T3 (de) |
| WO (1) | WO2006056340A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2547421T3 (es) | 2005-10-31 | 2015-10-06 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para diagnosticar y tratar el cáncer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| EP1900819A1 (de) * | 2006-09-15 | 2008-03-19 | Frankgen Biotechnologie AG | Versuchstier für die Selektion und Bestätigung von aktiven Mitteln gegen Lungenemphysem und kolorektaler Krebs |
| US20090181415A1 (en) * | 2007-12-20 | 2009-07-16 | Hans Marcus Ludwig Bitter | Prediction of genotoxicity |
| NZ592338A (en) | 2008-09-26 | 2012-11-30 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| EP2199794A1 (de) | 2008-12-17 | 2010-06-23 | Universiteit Maastricht | Verfahren zur Identifizierung von krebserregenden Verbindungen |
| GB0921712D0 (en) | 2009-12-11 | 2010-01-27 | Ge Healthcare Uk Ltd | Methods of detecting DNA damage |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| WO2011151321A1 (en) * | 2010-05-31 | 2011-12-08 | Institut Curie | Asf1b as a prognosis marker and therapeutic target in human cancer |
| DE102010024898B4 (de) * | 2010-06-24 | 2012-10-25 | Merck Patent Gmbh | Genexpressionsanalysen zur Charakterisierung und Identifizierung genotoxischer Verbindungen |
| EP2639314A1 (de) * | 2012-03-14 | 2013-09-18 | Universiteit Maastricht | In-vitro-Verfahren zur Vorhersage der In-vivo-Gentoxizität von chemischen Verbindungen |
| AU2013276950B2 (en) * | 2012-06-13 | 2018-07-26 | Merck Patent Gmbh | Protein expression analyses for identifying genotoxic compounds |
| US9266959B2 (en) | 2012-10-23 | 2016-02-23 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using frizzled-binding agents |
| US9359444B2 (en) | 2013-02-04 | 2016-06-07 | Oncomed Pharmaceuticals Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| WO2014170436A1 (en) * | 2013-04-19 | 2014-10-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for testing the genotoxicity of an agent |
| WO2017210117A1 (en) * | 2016-06-02 | 2017-12-07 | Board Of Trustees, Southern Illinois University | Treatment of endometriosis and niclosamide derivatives |
| JP2021522192A (ja) * | 2018-04-18 | 2021-08-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規抗チミジンキナーゼ抗体 |
| CN111041098B (zh) * | 2019-07-19 | 2021-11-30 | 江苏医药职业学院 | 检测富脯氨酸和卷曲蛋白2a表达水平的试剂的应用和试剂盒 |
| CN111675632B (zh) * | 2020-06-22 | 2021-06-22 | 湖南师范大学 | 一种可视化成像检测基因毒素Colibactin荧光分子探针及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0950717A1 (de) * | 1998-04-14 | 1999-10-20 | "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." | Diagnostisches System und Verfahren zur Bestimmung genotoxischer Substanzen in einer Probe |
| JP2002233364A (ja) * | 2001-02-09 | 2002-08-20 | Dai Ichi Seiyaku Co Ltd | 被検物質の毒性判定方法 |
| US20040005547A1 (en) * | 2002-03-14 | 2004-01-08 | Franziska Boess | Biomarkers and expression profiles for toxicology |
| AU2003284921A1 (en) | 2002-10-22 | 2004-05-13 | Iconix Pharmaceuticals, Inc. | Reticulocyte depletion signatures |
-
2005
- 2005-11-15 ES ES05804099T patent/ES2350231T3/es active Active
- 2005-11-15 AT AT05804099T patent/ATE480642T1/de not_active IP Right Cessation
- 2005-11-15 CN CNA2005800403590A patent/CN101065501A/zh active Pending
- 2005-11-15 EP EP05804099A patent/EP1817427B1/de not_active Not-in-force
- 2005-11-15 WO PCT/EP2005/012209 patent/WO2006056340A2/en active Application Filing
- 2005-11-15 JP JP2007541768A patent/JP4573876B2/ja not_active Expired - Fee Related
- 2005-11-15 CA CA2587548A patent/CA2587548C/en not_active Expired - Fee Related
- 2005-11-15 DE DE602005023517T patent/DE602005023517D1/de active Active
- 2005-11-23 US US11/286,216 patent/US7745152B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006056340A3 (en) | 2007-03-15 |
| CA2587548C (en) | 2010-10-05 |
| US7745152B2 (en) | 2010-06-29 |
| DE602005023517D1 (de) | 2010-10-21 |
| CN101065501A (zh) | 2007-10-31 |
| CA2587548A1 (en) | 2006-06-01 |
| ES2350231T3 (es) | 2011-01-20 |
| JP2008520216A (ja) | 2008-06-19 |
| EP1817427A2 (de) | 2007-08-15 |
| WO2006056340A2 (en) | 2006-06-01 |
| JP4573876B2 (ja) | 2010-11-04 |
| US20060110768A1 (en) | 2006-05-25 |
| EP1817427B1 (de) | 2010-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |