ATE480642T1 - Verfahren zur bestimmung von genotoxizität - Google Patents

Verfahren zur bestimmung von genotoxizität

Info

Publication number
ATE480642T1
ATE480642T1 AT05804099T AT05804099T ATE480642T1 AT E480642 T1 ATE480642 T1 AT E480642T1 AT 05804099 T AT05804099 T AT 05804099T AT 05804099 T AT05804099 T AT 05804099T AT E480642 T1 ATE480642 T1 AT E480642T1
Authority
AT
Austria
Prior art keywords
genotoxicity
determining
determining genotoxicity
reagents
methods
Prior art date
Application number
AT05804099T
Other languages
English (en)
Inventor
John Allard
Dee Aud
Guochun Liao
Gary Peltz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE480642T1 publication Critical patent/ATE480642T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05804099T 2004-11-24 2005-11-15 Verfahren zur bestimmung von genotoxizität ATE480642T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63067204P 2004-11-24 2004-11-24
PCT/EP2005/012209 WO2006056340A2 (en) 2004-11-24 2005-11-15 Method for determining genotoxicity

Publications (1)

Publication Number Publication Date
ATE480642T1 true ATE480642T1 (de) 2010-09-15

Family

ID=35709224

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05804099T ATE480642T1 (de) 2004-11-24 2005-11-15 Verfahren zur bestimmung von genotoxizität

Country Status (9)

Country Link
US (1) US7745152B2 (de)
EP (1) EP1817427B1 (de)
JP (1) JP4573876B2 (de)
CN (1) CN101065501A (de)
AT (1) ATE480642T1 (de)
CA (1) CA2587548C (de)
DE (1) DE602005023517D1 (de)
ES (1) ES2350231T3 (de)
WO (1) WO2006056340A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2481756T3 (pl) 2005-10-31 2018-02-28 Oncomed Pharmaceuticals, Inc. Kompozycje i sposoby diagnozowania i leczenia nowotworu
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1900819A1 (de) * 2006-09-15 2008-03-19 Frankgen Biotechnologie AG Versuchstier für die Selektion und Bestätigung von aktiven Mitteln gegen Lungenemphysem und kolorektaler Krebs
US20090181415A1 (en) * 2007-12-20 2009-07-16 Hans Marcus Ludwig Bitter Prediction of genotoxicity
NZ592338A (en) 2008-09-26 2012-11-30 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
EP2199794A1 (de) 2008-12-17 2010-06-23 Universiteit Maastricht Verfahren zur Identifizierung von krebserregenden Verbindungen
GB0921712D0 (en) 2009-12-11 2010-01-27 Ge Healthcare Uk Ltd Methods of detecting DNA damage
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
AU2011235904B2 (en) 2010-04-01 2015-10-08 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US20130149320A1 (en) * 2010-05-31 2013-06-13 Centre National De La Recherche Scientifique Asf1b as a Prognosis Marker and Therapeutic Target in Human Cancer
DE102010024898B4 (de) * 2010-06-24 2012-10-25 Merck Patent Gmbh Genexpressionsanalysen zur Charakterisierung und Identifizierung genotoxischer Verbindungen
EP2639314A1 (de) * 2012-03-14 2013-09-18 Universiteit Maastricht In-vitro-Verfahren zur Vorhersage der In-vivo-Gentoxizität von chemischen Verbindungen
WO2013185884A1 (en) * 2012-06-13 2013-12-19 Merck Patent Gmbh Protein expression analyses for identifying genotoxic compounds
US9266959B2 (en) 2012-10-23 2016-02-23 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using frizzled-binding agents
US9359444B2 (en) 2013-02-04 2016-06-07 Oncomed Pharmaceuticals Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160084823A1 (en) * 2013-04-19 2016-03-24 INSERM (Institut National de la Santé et de la Recherche Médicale Methods and kits for testing the genotoxicity of an agent
WO2017210117A1 (en) * 2016-06-02 2017-12-07 Board Of Trustees, Southern Illinois University Treatment of endometriosis and niclosamide derivatives
CN111936522B (zh) * 2018-04-18 2024-07-02 豪夫迈·罗氏有限公司 新型抗胸苷激酶抗体
CN111041098B (zh) * 2019-07-19 2021-11-30 江苏医药职业学院 检测富脯氨酸和卷曲蛋白2a表达水平的试剂的应用和试剂盒
CN111675632B (zh) * 2020-06-22 2021-06-22 湖南师范大学 一种可视化成像检测基因毒素Colibactin荧光分子探针及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950717A1 (de) * 1998-04-14 1999-10-20 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Diagnostisches System und Verfahren zur Bestimmung genotoxischer Substanzen in einer Probe
JP2002233364A (ja) * 2001-02-09 2002-08-20 Dai Ichi Seiyaku Co Ltd 被検物質の毒性判定方法
US20040005547A1 (en) * 2002-03-14 2004-01-08 Franziska Boess Biomarkers and expression profiles for toxicology
AU2003284921A1 (en) 2002-10-22 2004-05-13 Iconix Pharmaceuticals, Inc. Reticulocyte depletion signatures

Also Published As

Publication number Publication date
WO2006056340A2 (en) 2006-06-01
DE602005023517D1 (de) 2010-10-21
US20060110768A1 (en) 2006-05-25
JP4573876B2 (ja) 2010-11-04
ES2350231T3 (es) 2011-01-20
EP1817427B1 (de) 2010-09-08
WO2006056340A3 (en) 2007-03-15
CA2587548A1 (en) 2006-06-01
JP2008520216A (ja) 2008-06-19
CA2587548C (en) 2010-10-05
CN101065501A (zh) 2007-10-31
EP1817427A2 (de) 2007-08-15
US7745152B2 (en) 2010-06-29

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