DE602005023517D1 - Verfahren zur bestimmung von genotoxizität - Google Patents

Verfahren zur bestimmung von genotoxizität

Info

Publication number
DE602005023517D1
DE602005023517D1 DE602005023517T DE602005023517T DE602005023517D1 DE 602005023517 D1 DE602005023517 D1 DE 602005023517D1 DE 602005023517 T DE602005023517 T DE 602005023517T DE 602005023517 T DE602005023517 T DE 602005023517T DE 602005023517 D1 DE602005023517 D1 DE 602005023517D1
Authority
DE
Germany
Prior art keywords
genotoxicity
determining
determining genotoxicity
reagents
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005023517T
Other languages
English (en)
Inventor
John David Allard
Dee Marie Aud
Guochun Liao
Gary Allen Peltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602005023517D1 publication Critical patent/DE602005023517D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
DE602005023517T 2004-11-24 2005-11-15 Verfahren zur bestimmung von genotoxizität Active DE602005023517D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63067204P 2004-11-24 2004-11-24
PCT/EP2005/012209 WO2006056340A2 (en) 2004-11-24 2005-11-15 Method for determining genotoxicity

Publications (1)

Publication Number Publication Date
DE602005023517D1 true DE602005023517D1 (de) 2010-10-21

Family

ID=35709224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005023517T Active DE602005023517D1 (de) 2004-11-24 2005-11-15 Verfahren zur bestimmung von genotoxizität

Country Status (9)

Country Link
US (1) US7745152B2 (de)
EP (1) EP1817427B1 (de)
JP (1) JP4573876B2 (de)
CN (1) CN101065501A (de)
AT (1) ATE480642T1 (de)
CA (1) CA2587548C (de)
DE (1) DE602005023517D1 (de)
ES (1) ES2350231T3 (de)
WO (1) WO2006056340A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CA2628116A1 (en) 2005-10-31 2007-12-13 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP1900819A1 (de) * 2006-09-15 2008-03-19 Frankgen Biotechnologie AG Versuchstier für die Selektion und Bestätigung von aktiven Mitteln gegen Lungenemphysem und kolorektaler Krebs
US20090181415A1 (en) * 2007-12-20 2009-07-16 Hans Marcus Ludwig Bitter Prediction of genotoxicity
WO2010037041A2 (en) 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
EP2199794A1 (de) 2008-12-17 2010-06-23 Universiteit Maastricht Verfahren zur Identifizierung von krebserregenden Verbindungen
GB0921712D0 (en) 2009-12-11 2010-01-27 Ge Healthcare Uk Ltd Methods of detecting DNA damage
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
WO2011151321A1 (en) * 2010-05-31 2011-12-08 Institut Curie Asf1b as a prognosis marker and therapeutic target in human cancer
DE102010024898B4 (de) * 2010-06-24 2012-10-25 Merck Patent Gmbh Genexpressionsanalysen zur Charakterisierung und Identifizierung genotoxischer Verbindungen
EP2639314A1 (de) * 2012-03-14 2013-09-18 Universiteit Maastricht In-vitro-Verfahren zur Vorhersage der In-vivo-Gentoxizität von chemischen Verbindungen
US20150140123A1 (en) * 2012-06-13 2015-05-21 Merck Patent Gmbh Protein expression analyses for identifying genotoxic compounds
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160084823A1 (en) * 2013-04-19 2016-03-24 INSERM (Institut National de la Santé et de la Recherche Médicale Methods and kits for testing the genotoxicity of an agent
WO2017210117A1 (en) * 2016-06-02 2017-12-07 Board Of Trustees, Southern Illinois University Treatment of endometriosis and niclosamide derivatives
CN111041098B (zh) * 2019-07-19 2021-11-30 江苏医药职业学院 检测富脯氨酸和卷曲蛋白2a表达水平的试剂的应用和试剂盒
CN111675632B (zh) * 2020-06-22 2021-06-22 湖南师范大学 一种可视化成像检测基因毒素Colibactin荧光分子探针及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950717A1 (de) * 1998-04-14 1999-10-20 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Diagnostisches System und Verfahren zur Bestimmung genotoxischer Substanzen in einer Probe
JP2002233364A (ja) * 2001-02-09 2002-08-20 Dai Ichi Seiyaku Co Ltd 被検物質の毒性判定方法
JP2003304888A (ja) * 2002-03-14 2003-10-28 F Hoffmann La Roche Ag 化合物の毒性予測のための方法
AU2003284921A1 (en) 2002-10-22 2004-05-13 Iconix Pharmaceuticals, Inc. Reticulocyte depletion signatures

Also Published As

Publication number Publication date
CA2587548A1 (en) 2006-06-01
CN101065501A (zh) 2007-10-31
US7745152B2 (en) 2010-06-29
EP1817427A2 (de) 2007-08-15
ES2350231T3 (es) 2011-01-20
WO2006056340A2 (en) 2006-06-01
WO2006056340A3 (en) 2007-03-15
US20060110768A1 (en) 2006-05-25
JP4573876B2 (ja) 2010-11-04
JP2008520216A (ja) 2008-06-19
ATE480642T1 (de) 2010-09-15
CA2587548C (en) 2010-10-05
EP1817427B1 (de) 2010-09-08

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