DE60318826D1 - Alkoxypyridinderivate - Google Patents

Alkoxypyridinderivate

Info

Publication number
DE60318826D1
DE60318826D1 DE60318826T DE60318826T DE60318826D1 DE 60318826 D1 DE60318826 D1 DE 60318826D1 DE 60318826 T DE60318826 T DE 60318826T DE 60318826 T DE60318826 T DE 60318826T DE 60318826 D1 DE60318826 D1 DE 60318826D1
Authority
DE
Germany
Prior art keywords
alkoxypyridinderivate
purin
imidazo
pyridin
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318826T
Other languages
English (en)
Other versions
DE60318826T2 (de
Inventor
Wolf-Ruediger Ulrich
Rainer Boer
Degenhard Marx
Manfrid Eltze
Thomas Klein
Ruediger Nave
Ulrich Graedler
Thomas Fuchss
Johannes Barsig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Application granted granted Critical
Publication of DE60318826D1 publication Critical patent/DE60318826D1/de
Publication of DE60318826T2 publication Critical patent/DE60318826T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
DE60318826T 2002-03-27 2003-03-25 Alkoxypyridinderivate Expired - Lifetime DE60318826T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02007049 2002-03-27
EP02007049 2002-03-27
PCT/EP2003/003076 WO2003080607A1 (en) 2002-03-27 2003-03-25 Novel alkoxypyridine-derivatives

Publications (2)

Publication Number Publication Date
DE60318826D1 true DE60318826D1 (de) 2008-03-13
DE60318826T2 DE60318826T2 (de) 2009-01-22

Family

ID=28051741

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318826T Expired - Lifetime DE60318826T2 (de) 2002-03-27 2003-03-25 Alkoxypyridinderivate

Country Status (19)

Country Link
US (1) US7138399B2 (de)
EP (1) EP1490366B1 (de)
JP (1) JP4448695B2 (de)
KR (1) KR20050002910A (de)
CN (1) CN1307176C (de)
AT (1) ATE384722T1 (de)
AU (1) AU2003226706A1 (de)
BR (1) BR0308785A (de)
CA (1) CA2480385A1 (de)
DE (1) DE60318826T2 (de)
ES (1) ES2300599T3 (de)
HK (1) HK1078850A1 (de)
IL (1) IL163625A0 (de)
MX (1) MXPA04009283A (de)
NO (1) NO20044633L (de)
NZ (1) NZ535959A (de)
PL (1) PL372409A1 (de)
WO (1) WO2003080607A1 (de)
ZA (1) ZA200407766B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1675853B1 (de) 2003-10-01 2008-06-18 Nycomed GmbH Imidazo[4,5-b]pyridinderivate als inhibitoren der induzierbaren no-synthase
RS20060206A (en) 2003-10-01 2008-08-07 Altana Pharma Ag., Aminopyridine-derivatives as inducible no-synthase inhibitors
ATE399168T1 (de) 2003-10-01 2008-07-15 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
BRPI0414972A (pt) 2003-10-01 2006-11-07 Altana Pharma Ag derivados de imidazopiridinas como inibidores de no-sintase induzìvel
AU2004276013A1 (en) * 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inducible no-synthase inhibitors
US8088935B2 (en) 2003-12-23 2012-01-03 Ironwood Pharmaceuticals, Inc. Compounds and methods for the treatment of asthma
KR20070037578A (ko) 2004-05-28 2007-04-05 알타나 파마 아게 테트라히드로피리도티오펜
WO2005120642A2 (en) 2004-06-11 2005-12-22 Altana Pharma Ag Tetrahydropyridothiophenes for treating hyperproliferative disorders
CA2596202A1 (en) 2005-02-09 2006-08-17 Altana Pharma Ag Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
CA2596501A1 (en) 2005-02-11 2006-08-17 Altana Pharma Ag Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
AU2006228142A1 (en) * 2005-03-31 2006-10-05 Nycomed Gmbh Imidazopyridine derivatives useful as iNOS inhibitors
EP1893618A2 (de) 2005-05-25 2008-03-05 Nycomed GmbH Tetrahydropyridothiophene zur verwendung bei der behandlung von krebs
CA2609003A1 (en) 2005-05-25 2006-11-30 Nycomed Gmbh Tetrahydropyridothiophenes for use in the treatment of cancer
UY29823A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
WO2008031788A1 (en) * 2006-09-12 2008-03-20 Nycomed Gmbh Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase
US20080139608A1 (en) * 2006-12-06 2008-06-12 Universiteit Leiden 2,6,8, Trisubstituted 1-deazapurines and their different uses
CN105001219A (zh) * 2011-02-25 2015-10-28 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
EP3495366A1 (de) * 2011-07-15 2019-06-12 Shionogi & Co., Ltd Azabenzimidazolderivat mit ampk-aktivierender wirkung
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
GB8307865D0 (en) 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare

Also Published As

Publication number Publication date
ZA200407766B (en) 2006-06-28
DE60318826T2 (de) 2009-01-22
EP1490366B1 (de) 2008-01-23
ATE384722T1 (de) 2008-02-15
US7138399B2 (en) 2006-11-21
MXPA04009283A (es) 2005-01-25
PL372409A1 (en) 2005-07-25
CA2480385A1 (en) 2003-10-02
CN1642955A (zh) 2005-07-20
EP1490366A1 (de) 2004-12-29
NZ535959A (en) 2006-05-26
JP4448695B2 (ja) 2010-04-14
NO20044633L (no) 2004-12-23
US20050171125A1 (en) 2005-08-04
JP2005525388A (ja) 2005-08-25
HK1078850A1 (en) 2006-03-24
IL163625A0 (en) 2005-12-18
CN1307176C (zh) 2007-03-28
AU2003226706A1 (en) 2003-10-08
BR0308785A (pt) 2005-01-11
WO2003080607A1 (en) 2003-10-02
KR20050002910A (ko) 2005-01-10
ES2300599T3 (es) 2008-06-16

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