DE60316547D1 - Doping bei der walk-through-mutagenese - Google Patents

Doping bei der walk-through-mutagenese

Info

Publication number
DE60316547D1
DE60316547D1 DE60316547T DE60316547T DE60316547D1 DE 60316547 D1 DE60316547 D1 DE 60316547D1 DE 60316547 T DE60316547 T DE 60316547T DE 60316547 T DE60316547 T DE 60316547T DE 60316547 D1 DE60316547 D1 DE 60316547D1
Authority
DE
Germany
Prior art keywords
prototype
predetermined
synthesis
polypeptide
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60316547T
Other languages
English (en)
Other versions
DE60316547T2 (de
Inventor
Roberto Crea
Guido Cappuccilli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioren LLC
Original Assignee
Bioren LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioren LLC filed Critical Bioren LLC
Publication of DE60316547D1 publication Critical patent/DE60316547D1/de
Application granted granted Critical
Publication of DE60316547T2 publication Critical patent/DE60316547T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
DE60316547T 2002-04-17 2003-04-16 Doping bei der walk-through-mutagenese Expired - Lifetime DE60316547T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37368602P 2002-04-17 2002-04-17
US373686P 2002-04-17
PCT/US2003/011935 WO2003089671A1 (en) 2002-04-17 2003-04-16 'doping' in walk-through mutagenesis

Publications (2)

Publication Number Publication Date
DE60316547D1 true DE60316547D1 (de) 2007-11-08
DE60316547T2 DE60316547T2 (de) 2008-07-03

Family

ID=29251060

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60316547T Expired - Lifetime DE60316547T2 (de) 2002-04-17 2003-04-16 Doping bei der walk-through-mutagenese

Country Status (12)

Country Link
US (1) US20040033569A1 (de)
EP (1) EP1495142B1 (de)
JP (1) JP4433798B2 (de)
CN (1) CN1653193A (de)
AT (1) ATE374255T1 (de)
AU (1) AU2003228568A1 (de)
CA (1) CA2482769C (de)
DE (1) DE60316547T2 (de)
ES (1) ES2295584T3 (de)
MX (1) MXPA04010222A (de)
NZ (1) NZ535928A (de)
WO (1) WO2003089671A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007000104A (es) * 2004-07-06 2007-07-18 Bioren Inc Anticuerpos anti-tnf-? de gran afinidad y metodo.
CA2572917C (en) * 2004-07-06 2012-04-03 Bioren Inc. Look-through mutagenesis for developing altered polypeptides with enhanced properties
CA2572961C (en) 2004-07-06 2016-08-16 Bioren, Inc. Universal antibody libraries
WO2009023184A2 (en) 2007-08-10 2009-02-19 Protelix, Inc. Universal fibronectin type iii binding-domain libraries
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US8680019B2 (en) 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
JP4251406B2 (ja) * 1990-04-05 2009-04-08 クレア，ロベルト ウォーク―スルー突然変異誘発
EP0728015B1 (de) * 1992-06-18 2006-03-08 Creagen, Inc. Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen
WO1997030150A2 (en) * 1996-02-15 1997-08-21 Pangenetics B.V. Molecules for the induction of immunological tolerance
DE60033455T2 (de) * 1999-12-27 2007-11-29 Crucell Holland B.V. Menschlischer monoklonaler Antikörper gegen Ep-CAM und dessen Verwendung in Krebstherapie

Also Published As

Publication number Publication date
CA2482769C (en) 2013-10-08
MXPA04010222A (es) 2005-03-07
ES2295584T3 (es) 2008-04-16
WO2003089671A1 (en) 2003-10-30
EP1495142B1 (de) 2007-09-26
JP2005523026A (ja) 2005-08-04
CA2482769A1 (en) 2003-10-30
CN1653193A (zh) 2005-08-10
NZ535928A (en) 2006-09-29
EP1495142A4 (de) 2005-06-29
ATE374255T1 (de) 2007-10-15
DE60316547T2 (de) 2008-07-03
US20040033569A1 (en) 2004-02-19
JP4433798B2 (ja) 2010-03-17
AU2003228568A1 (en) 2003-11-03
EP1495142A1 (de) 2005-01-12

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