DE60315842D1 - Verwendung von hesperidin oder einem seiner derivate zur herstellung eines medikaments für die stimulierung der knochenbildung - Google Patents
Verwendung von hesperidin oder einem seiner derivate zur herstellung eines medikaments für die stimulierung der knochenbildungInfo
- Publication number
- DE60315842D1 DE60315842D1 DE60315842T DE60315842T DE60315842D1 DE 60315842 D1 DE60315842 D1 DE 60315842D1 DE 60315842 T DE60315842 T DE 60315842T DE 60315842 T DE60315842 T DE 60315842T DE 60315842 D1 DE60315842 D1 DE 60315842D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- manufacture
- bone formation
- hesperidine
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 title abstract 2
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000011164 ossification Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 abstract 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 abstract 1
- 229940025878 hesperidin Drugs 0.000 abstract 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0208171 | 2002-06-28 | ||
| FR0208171A FR2841472B1 (fr) | 2002-06-28 | 2002-06-28 | Composition nutritionnelle ou therapeutique contenant le compose hesperidine ou l'un de ses derives |
| PCT/FR2003/002005 WO2004002496A1 (fr) | 2002-06-28 | 2003-06-27 | Utilisation de l'hesperidine ou l'un de ses derives pour la fabrication d'un medicament destine a stimuler la formation osseuse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60315842D1 true DE60315842D1 (de) | 2007-10-04 |
| DE60315842T2 DE60315842T2 (de) | 2008-05-21 |
Family
ID=29725026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315842T Expired - Lifetime DE60315842T2 (de) | 2002-06-28 | 2003-06-27 | Verwendung von hesperidin oder einem seiner derivate zur herstellung eines medikaments für die stimulierung der knochenbildung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8859612B2 (de) |
| EP (1) | EP1536806B1 (de) |
| JP (1) | JP2005537241A (de) |
| CN (2) | CN101822687A (de) |
| AT (1) | ATE370739T1 (de) |
| AU (1) | AU2003255695B2 (de) |
| CA (1) | CA2491167C (de) |
| DE (1) | DE60315842T2 (de) |
| ES (1) | ES2291685T3 (de) |
| FR (1) | FR2841472B1 (de) |
| HK (1) | HK1081866A1 (de) |
| PT (1) | PT1536806E (de) |
| RU (1) | RU2320346C2 (de) |
| WO (1) | WO2004002496A1 (de) |
| ZA (1) | ZA200500835B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368442B1 (de) | 2005-07-27 | 2014-12-17 | Symrise AG | Verwendung von Hesperetin zur Verstärkung von süßem Geschmack |
| US20070190209A1 (en) * | 2006-02-10 | 2007-08-16 | Mannatech, Inc. | All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization |
| US20070218111A1 (en) * | 2006-03-16 | 2007-09-20 | Western Holdings, Llc | Strontium compositions for bones |
| CN101537003B (zh) * | 2006-06-15 | 2010-12-08 | 安徽医科大学 | 7,3'-二甲氧基橙皮素在制备抗炎免疫药物中的应用 |
| EP1891967B1 (de) * | 2006-08-24 | 2019-11-20 | Société des Produits Nestlé S.A. | Flavonoid enthaltende Zusammensetzung mit lang anhaltender Absorption |
| JP2009234924A (ja) * | 2008-03-25 | 2009-10-15 | Kinji Ishida | 免疫回復剤及びそれを含有する飼料組成物 |
| EP2286669A1 (de) | 2009-07-29 | 2011-02-23 | Nestec S.A. | Flavanonhaltige Lebensmittelzusammensetzungen |
| EP2289343A1 (de) | 2009-07-29 | 2011-03-02 | Nestec S.A. | Flavanonhaltige Lebensmittelzusammensetzungen |
| FR3005419B1 (fr) | 2013-05-13 | 2015-09-04 | Agronomique Inst Nat Rech | Utilisation d'une association de deux composes pour le traitement et/ou la prevention de troubles osseux |
| US20200108088A1 (en) * | 2013-05-29 | 2020-04-09 | Societe Des Produits Nestle S.A. | Compositions for use in cartilage breakdown |
| CN112843045A (zh) * | 2016-07-06 | 2021-05-28 | 天津中医药大学 | 3`-羟基鹰嘴豆素a的用途以及包含其的药物组合物 |
| US20180228023A1 (en) * | 2017-02-09 | 2018-08-09 | International Business Machines Corporation | Angled fiberglass cloth weaves |
| US11517603B2 (en) * | 2017-09-21 | 2022-12-06 | Hokuriku University | Bone remodeling accelerator |
| CN111067915A (zh) * | 2020-01-09 | 2020-04-28 | 昆明医科大学 | 老鹳草素在制备用于治疗维生素d不足和/或缺乏疾病的药物中的用途 |
| RU2742030C1 (ru) * | 2020-06-11 | 2021-02-01 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Конъюгат гесперидина и способ его получения |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB486898A (en) | 1936-12-12 | 1938-06-13 | Ig Farbenindustrie Ag | Manufacture of substances resembling vitamines from plants |
| US2400693A (en) | 1943-03-06 | 1946-05-21 | Fruit Growers Exchange Ca | Method of manufacturing hesperidin |
| US2442110A (en) | 1943-11-22 | 1948-05-25 | Fruit Growers Exchange Ca | Process for the recovery of hesperidin |
| GB858784A (en) | 1957-08-27 | 1961-01-18 | Takeda Pharmaceutical | Water-soluble methylhesperidins and their production |
| US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| FR2679134B1 (fr) | 1991-07-19 | 1993-10-22 | Sablon Louis | Compositions cosmetiques pour la regulation de la pigmentation cutanee comprenant un extrait d'eclipta alba. |
| JPH0725761A (ja) * | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
| US5506211A (en) * | 1994-05-09 | 1996-04-09 | The Uab Research Foundation | Genistein for use in inhibiting osteroclasts |
| FR2725365B1 (fr) | 1994-10-07 | 1996-11-08 | Oreal | Composition nettoyante et/ou demaquillante contenant un alcool et un compose phosphate |
| JPH08188593A (ja) | 1995-01-10 | 1996-07-23 | Wakayama Agribio Kenkyu Center:Kk | 柑橘類に含有されるヘスペリジンの抽出方法および回収方法 |
| JP3833775B2 (ja) | 1996-06-26 | 2006-10-18 | 株式会社林原生物化学研究所 | 酵素処理ヘスペリジンおよびその製造方法ならびに酵素処理ヘスペリジンの使用方法 |
| KR100213895B1 (ko) | 1996-10-14 | 1999-08-02 | 박원훈 | 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 포함하는 심혈관 질환 예방및 치료제 조성물 |
| WO1998042859A1 (en) | 1997-03-24 | 1998-10-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | PROCESS FOR PRODUCING α-MONOGLUCOSYLHESPERIDIN-RICH SUBSTANCE |
| US6340703B1 (en) | 1997-05-01 | 2002-01-22 | Novogen, Inc. | Treatment or prevention of osteoporosis |
| DE19742025A1 (de) | 1997-09-24 | 1999-03-25 | Beiersdorf Ag | Verwendung von Flavonen und Flavonoiden zur Hautaufhellung oder zur Verhinderung der durch oxidative Proteinaggregation hervorgerufenen Altersflecken |
| CA2307890A1 (en) * | 1997-10-28 | 1999-05-06 | Jun-Sung Lee | Hesperidin and hesperetin as inhibitor of acyl coa-cholesterol-o-acyltransferase, inhibitor of macrophage-lipid complex accumulation on the arterial wall and preventive or treating agent for hepatic diseases |
| US20010046977A1 (en) | 1997-11-25 | 2001-11-29 | Merck & Co., Inc. | Use of alendronate for the prevention of osteoporosis |
| JP4295840B2 (ja) * | 1997-12-09 | 2009-07-15 | 株式会社林原生物化学研究所 | 血行改善剤 |
| KR100284129B1 (ko) | 1998-06-03 | 2001-03-02 | 박호군 | 헤스페리딘또는헤스페레틴을포함하는혈소판응집억제용조성물 |
| ID28460A (id) * | 1998-07-08 | 2001-05-24 | Lipogenics Inc | Komposisi dan metoda untuk perlakuan dan pencegahan penyakit tulang dengan menggunakan tocotrienol |
| KR20000019717A (ko) * | 1998-09-15 | 2000-04-15 | 박호군 | 루틴 및 쿼세틴을 포함하는 고지혈증, 동맥경화증 및 간 질환의예방 및 치료용 조성물 |
| GB9821671D0 (en) | 1998-10-05 | 1998-12-02 | Muhlbauer Roman C | Plant extracts for the treatment of increased bone resorption |
| JP2001114675A (ja) * | 1999-10-12 | 2001-04-24 | Fancl Corp | ビタミン組成物 |
| EP1127572A3 (de) * | 2000-02-25 | 2003-05-02 | Basf Aktiengesellschaft | Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten |
| AU5311301A (en) | 2000-04-20 | 2001-11-07 | Upjohn Co | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| KR100408231B1 (ko) * | 2000-08-14 | 2003-12-01 | 한국 한의학 연구원 | 골다공증 예방 및 치료용 플라보노이드 유도체 |
| JP4813652B2 (ja) * | 2000-12-04 | 2011-11-09 | 丸善製薬株式会社 | マトリックスメタロプロテアーゼ阻害剤 |
| JP2002234844A (ja) * | 2000-12-05 | 2002-08-23 | Toyo Seito Kk | 骨密度向上剤およびその利用 |
-
2002
- 2002-06-28 FR FR0208171A patent/FR2841472B1/fr not_active Expired - Fee Related
-
2003
- 2003-06-27 JP JP2004516888A patent/JP2005537241A/ja active Pending
- 2003-06-27 WO PCT/FR2003/002005 patent/WO2004002496A1/fr active IP Right Grant
- 2003-06-27 CN CN201010155745A patent/CN101822687A/zh active Pending
- 2003-06-27 CN CN038203480A patent/CN1678327B/zh not_active Expired - Fee Related
- 2003-06-27 PT PT03761660T patent/PT1536806E/pt unknown
- 2003-06-27 AU AU2003255695A patent/AU2003255695B2/en not_active Ceased
- 2003-06-27 EP EP03761660A patent/EP1536806B1/de not_active Expired - Lifetime
- 2003-06-27 DE DE60315842T patent/DE60315842T2/de not_active Expired - Lifetime
- 2003-06-27 US US10/519,386 patent/US8859612B2/en not_active Expired - Fee Related
- 2003-06-27 ES ES03761660T patent/ES2291685T3/es not_active Expired - Lifetime
- 2003-06-27 AT AT03761660T patent/ATE370739T1/de not_active IP Right Cessation
- 2003-06-27 CA CA2491167A patent/CA2491167C/fr not_active Expired - Fee Related
- 2003-06-27 RU RU2005102093/15A patent/RU2320346C2/ru not_active IP Right Cessation
-
2005
- 2005-01-27 ZA ZA200500835A patent/ZA200500835B/en unknown
-
2006
- 2006-02-22 HK HK06102318.5A patent/HK1081866A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2841472B1 (fr) | 2006-02-24 |
| US8859612B2 (en) | 2014-10-14 |
| AU2003255695A1 (en) | 2004-01-19 |
| HK1081866A1 (en) | 2006-05-26 |
| AU2003255695B2 (en) | 2008-04-03 |
| RU2320346C2 (ru) | 2008-03-27 |
| CN1678327B (zh) | 2013-04-17 |
| EP1536806A1 (de) | 2005-06-08 |
| JP2005537241A (ja) | 2005-12-08 |
| RU2005102093A (ru) | 2005-08-10 |
| EP1536806B1 (de) | 2007-08-22 |
| DE60315842T2 (de) | 2008-05-21 |
| CA2491167C (fr) | 2012-05-15 |
| FR2841472A1 (fr) | 2004-01-02 |
| CN1678327A (zh) | 2005-10-05 |
| CA2491167A1 (fr) | 2004-01-08 |
| ATE370739T1 (de) | 2007-09-15 |
| PT1536806E (pt) | 2007-11-05 |
| WO2004002496A1 (fr) | 2004-01-08 |
| ZA200500835B (en) | 2005-08-11 |
| CN101822687A (zh) | 2010-09-08 |
| ES2291685T3 (es) | 2008-03-01 |
| US20060034893A1 (en) | 2006-02-16 |
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