DE60111574D1 - Bisphosphonate-enthaltenden zusammensetzungen zur vorbeugung und/oder heilung von metabolischen knochenkrankheiten, verfahren zu ihren herstellung und benutzung dieser zusammensetzungen - Google Patents
Bisphosphonate-enthaltenden zusammensetzungen zur vorbeugung und/oder heilung von metabolischen knochenkrankheiten, verfahren zu ihren herstellung und benutzung dieser zusammensetzungenInfo
- Publication number
- DE60111574D1 DE60111574D1 DE60111574T DE60111574T DE60111574D1 DE 60111574 D1 DE60111574 D1 DE 60111574D1 DE 60111574 T DE60111574 T DE 60111574T DE 60111574 T DE60111574 T DE 60111574T DE 60111574 D1 DE60111574 D1 DE 60111574D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- bisphosphonate
- healing
- prevention
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title 2
- 208000029725 Metabolic bone disease Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2001/000690 WO2002058708A1 (en) | 2001-01-23 | 2001-01-23 | Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60111574D1 true DE60111574D1 (de) | 2005-07-21 |
DE60111574T2 DE60111574T2 (de) | 2006-05-11 |
Family
ID=8164260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60111574T Expired - Lifetime DE60111574T2 (de) | 2001-01-23 | 2001-01-23 | Bisphosphonate enthaltende Zusammensetzungen zur Vorbeugung und/oder Heilung von metabolischen Knochenkrankheiten, Verfahren zu ihrer Herstellung und Benutzung dieser Zusammensetzungen |
Country Status (13)
Country | Link |
---|---|
US (2) | US7560490B2 (de) |
EP (1) | EP1372669B1 (de) |
JP (1) | JP2004519463A (de) |
KR (1) | KR100593510B1 (de) |
AR (1) | AR047480A1 (de) |
AT (1) | ATE297740T1 (de) |
BR (1) | BRPI0116865B8 (de) |
CA (1) | CA2431515C (de) |
DE (1) | DE60111574T2 (de) |
DK (1) | DK1372669T3 (de) |
ES (1) | ES2243457T3 (de) |
MX (1) | MXPA03006565A (de) |
WO (1) | WO2002058708A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1372669T3 (da) * | 2001-01-23 | 2005-10-17 | Gador Sa | Bisphosphonatholding sammensætning til forebyggelse og/eller behandling af metaboliske knoglesygdomme, fremgangsmåde til fremstilling af sådanne sammensætninger og anvendelse deraf |
TWI349553B (en) * | 2001-12-21 | 2011-10-01 | Procter & Gamble | Kit and use of bisphosphonate for treating high bone turnover |
NZ556278A (en) | 2002-05-10 | 2009-06-26 | Hoffmann La Roche | Bisphosphonic acid for the treatment and prevention of osteoperosis |
PT1596870E (pt) * | 2002-12-20 | 2007-10-15 | Hoffmann La Roche | Formulação com uma dose elevada de ibandronato |
WO2006039721A2 (en) * | 2004-10-08 | 2006-04-13 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
WO2008128056A1 (en) * | 2004-10-08 | 2008-10-23 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
JP2009530414A (ja) * | 2006-03-17 | 2009-08-27 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | ビスホスホネート化合物及び方法 |
DE602006020137D1 (de) * | 2006-09-04 | 2011-03-31 | Gador Sa | Flüssige Zusammensetzung für die Behandlung und/oder Verhinderung von verschiedenen metabolischen Knochenkrankheiten, Verwendung davon und Vorbereitungsprozess. |
CA2711413A1 (en) * | 2008-02-05 | 2009-08-13 | Actavis Group Ptc Ehf | Alendronate formulations, method of making and method of use thereof |
FI20115315A0 (fi) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Menetelmä metallien keräämiseksi |
CN105410940B (zh) * | 2015-12-27 | 2018-08-24 | 山东阜丰发酵有限公司 | 一种包含黄原胶的保健食品 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2405254C2 (de) | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
US4313765A (en) * | 1980-09-24 | 1982-02-02 | Merck & Co., Inc. | Synergistic blends of cellulase-free xanthan gum and cellulosics |
US4446052A (en) | 1982-05-17 | 1984-05-01 | The Procter & Gamble Company | Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate |
US4639338A (en) | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
US4788220A (en) * | 1987-07-08 | 1988-11-29 | American Home Products Corporation (Del.) | Pediatric ibuprofen compositions |
FR2629716B1 (fr) * | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
FI89364C (fi) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
DE69231313T2 (de) * | 1991-11-22 | 2001-03-15 | Procter & Gamble Pharmaceuticals, Inc. | Risedronat enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe |
TW237386B (de) * | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
JP3332426B2 (ja) * | 1992-10-02 | 2002-10-07 | 太田製薬株式会社 | 大腸および小腸の検査用x線造影剤 |
EP1475091A1 (de) * | 1993-10-01 | 2004-11-10 | Roche Palo Alto LLC | Hochdosierte oral anzuwendende Suspensionen enthaltend Mycophenolat Mofetil |
US5674522A (en) * | 1993-10-07 | 1997-10-07 | Mcneil-Ppc, Inc. | Beverage concentrate for drug delivery |
BR9407869A (pt) * | 1993-10-19 | 1996-10-29 | Merck & Co Inc | Combinaçao composiçao farmacêutica e processo para o tratamento de osteoporose |
US5462932A (en) * | 1994-05-17 | 1995-10-31 | Merck & Co., Inc. | Oral liquid alendronate formulations |
NZ272608A (en) * | 1994-07-22 | 2000-05-26 | Lilly Co Eli | Inhibiting bone loss by administering a bisphosphonate and a second compound selected from various compounds, including 2-phenyl-3-aroylbenzothienes; bisphosphonate combination salts |
DE69534923T2 (de) | 1994-12-28 | 2006-11-23 | Gador S.A. | Anabolische zubereitung für knochenmasse enthaltend olpadronat |
JPH08333245A (ja) * | 1995-06-07 | 1996-12-17 | Taisho Pharmaceut Co Ltd | イブプロフェン懸濁液剤 |
TW442287B (en) * | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
EE03669B1 (et) * | 1996-10-04 | 2002-04-15 | Merck & Co., Inc. | Vedelad alendronaatpreparaadid ja nende valmistamismeetod |
UA72189C2 (uk) * | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
GB9815532D0 (en) * | 1998-07-17 | 1998-09-16 | Lek Pharmaceutical & Cvhemical | Pharmaceutical suspension formulation |
CO5160260A1 (es) * | 1999-02-19 | 2002-05-30 | Lilly Co Eli | Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido |
CA2376258A1 (en) * | 1999-06-02 | 2000-12-14 | The Procter & Gamble Company | Oral preparations of etidronate disodium |
US20020002169A1 (en) * | 1999-12-08 | 2002-01-03 | Griffin John H. | Protein kinase inhibitors |
AU2002231721A1 (en) * | 2000-12-18 | 2002-07-01 | Societe Des Produits Nestle S.A. | Stabilizer based on microcrystalline cellulose for drink and dressing formulations |
DK1372669T3 (da) * | 2001-01-23 | 2005-10-17 | Gador Sa | Bisphosphonatholding sammensætning til forebyggelse og/eller behandling af metaboliske knoglesygdomme, fremgangsmåde til fremstilling af sådanne sammensætninger og anvendelse deraf |
-
2001
- 2001-01-23 DK DK01911512T patent/DK1372669T3/da active
- 2001-01-23 WO PCT/EP2001/000690 patent/WO2002058708A1/en active IP Right Grant
- 2001-01-23 CA CA002431515A patent/CA2431515C/en not_active Expired - Lifetime
- 2001-01-23 MX MXPA03006565A patent/MXPA03006565A/es active IP Right Grant
- 2001-01-23 EP EP01911512A patent/EP1372669B1/de not_active Expired - Lifetime
- 2001-01-23 KR KR1020037009642A patent/KR100593510B1/ko active IP Right Grant
- 2001-01-23 DE DE60111574T patent/DE60111574T2/de not_active Expired - Lifetime
- 2001-01-23 ES ES01911512T patent/ES2243457T3/es not_active Expired - Lifetime
- 2001-01-23 BR BRPI0116865A patent/BRPI0116865B8/pt not_active IP Right Cessation
- 2001-01-23 JP JP2002559042A patent/JP2004519463A/ja active Pending
- 2001-01-23 US US10/466,897 patent/US7560490B2/en not_active Expired - Lifetime
- 2001-01-23 AT AT01911512T patent/ATE297740T1/de not_active IP Right Cessation
-
2002
- 2002-01-17 AR ARP020100154A patent/AR047480A1/es not_active Application Discontinuation
-
2009
- 2009-06-08 US US12/480,086 patent/US8853187B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2004519463A (ja) | 2004-07-02 |
DE60111574T2 (de) | 2006-05-11 |
DK1372669T3 (da) | 2005-10-17 |
CA2431515A1 (en) | 2002-08-01 |
US8853187B2 (en) | 2014-10-07 |
AR047480A1 (es) | 2006-01-25 |
KR20030086988A (ko) | 2003-11-12 |
US20090247491A1 (en) | 2009-10-01 |
ATE297740T1 (de) | 2005-07-15 |
WO2002058708A1 (en) | 2002-08-01 |
KR100593510B1 (ko) | 2006-06-28 |
US20040087550A1 (en) | 2004-05-06 |
CA2431515C (en) | 2008-01-22 |
BR0116865A (pt) | 2004-02-25 |
EP1372669B1 (de) | 2005-06-15 |
EP1372669A1 (de) | 2004-01-02 |
BRPI0116865B8 (pt) | 2021-05-25 |
MXPA03006565A (es) | 2005-07-29 |
US7560490B2 (en) | 2009-07-14 |
ES2243457T3 (es) | 2005-12-01 |
BR0116865B1 (pt) | 2014-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |