DE60313585D1 - Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen - Google Patents

Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen

Info

Publication number
DE60313585D1
DE60313585D1 DE60313585T DE60313585T DE60313585D1 DE 60313585 D1 DE60313585 D1 DE 60313585D1 DE 60313585 T DE60313585 T DE 60313585T DE 60313585 T DE60313585 T DE 60313585T DE 60313585 D1 DE60313585 D1 DE 60313585D1
Authority
DE
Germany
Prior art keywords
oligomers
contrastive
nmr
line
gadolinium chelate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60313585T
Other languages
English (en)
Other versions
DE60313585T2 (de
Inventor
Isabelle Nachman
Marc Port
Isabelle Raynal
Olivier Rousseaux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Application granted granted Critical
Publication of DE60313585D1 publication Critical patent/DE60313585D1/de
Publication of DE60313585T2 publication Critical patent/DE60313585T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/65812—Cyclic phosphazenes [P=N-]n, n>=3
    • C07F9/65815—Cyclic phosphazenes [P=N-]n, n>=3 n = 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60313585T 2002-03-05 2003-03-05 Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen Expired - Fee Related DE60313585T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0202791 2002-03-05
FR0202791A FR2836916B1 (fr) 2002-03-05 2002-03-05 Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
PCT/FR2003/000712 WO2003074523A2 (fr) 2002-03-05 2003-03-05 Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leur intermediaires de synthese

Publications (2)

Publication Number Publication Date
DE60313585D1 true DE60313585D1 (de) 2007-06-14
DE60313585T2 DE60313585T2 (de) 2007-12-27

Family

ID=27763565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60313585T Expired - Fee Related DE60313585T2 (de) 2002-03-05 2003-03-05 Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen

Country Status (7)

Country Link
US (1) US20070098643A1 (de)
EP (1) EP1480979B1 (de)
AT (1) ATE361299T1 (de)
AU (1) AU2003233361A1 (de)
DE (1) DE60313585T2 (de)
FR (1) FR2836916B1 (de)
WO (1) WO2003074523A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004307356A (ja) * 2003-04-02 2004-11-04 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 新規なデンドリマーおよび造影剤
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
ATE430146T1 (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
FR2883562B1 (fr) * 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1940841B9 (de) * 2005-10-07 2017-04-19 Guerbet Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist
BRPI0619198A2 (pt) * 2005-12-02 2011-09-20 Ge Healthcare As composto, composição, uso da composição, e, métodos para formação de imagem por rm e/ou de espectroscopia por rm, e para a preparação de compostos
EP2279190A1 (de) * 2008-04-18 2011-02-02 Ge Healthcare As Paramagnetische, um einen zentralen kern angeordnete chelate enthaltende verbindungen und ihre verwendung in der magnetresonanzbilddarstellung und spektroskopie
NO331773B1 (no) * 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
FR3069245B1 (fr) * 2017-07-21 2019-07-26 Guerbet Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales
BR112021001102B1 (pt) * 2018-08-06 2022-12-20 Bracco Imaging Spa Misturas isoméricas de um derivado de amida de gd(pcta - ácido tris-glutárico) e composições farmacêuticas
BR112021007707A2 (pt) 2018-11-23 2021-07-27 Bayer Aktiengesellschaft formulação de meios de contraste e processo de preparação da mesma
CN111875667B (zh) * 2020-07-16 2021-12-21 南方科技大学 有机金属螯合物及其制备方法与应用、探针
WO2022165424A1 (en) * 2021-02-01 2022-08-04 Inventure, LLC Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567411A (en) * 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale

Also Published As

Publication number Publication date
WO2003074523A3 (fr) 2004-03-25
DE60313585T2 (de) 2007-12-27
AU2003233361A1 (en) 2003-09-16
ATE361299T1 (de) 2007-05-15
AU2003233361A8 (en) 2003-09-16
EP1480979A2 (de) 2004-12-01
FR2836916B1 (fr) 2004-06-11
WO2003074523A2 (fr) 2003-09-12
US20070098643A1 (en) 2007-05-03
EP1480979B1 (de) 2007-05-02
FR2836916A1 (fr) 2003-09-12

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee